Evaluation of the protective roles of alpha-lipoic acid supplementation on nanomaterial-induced toxicity: A meta-analysis of in vitro and in vivo studies
Extensive exposure to nanomaterials causes oxidative stress and inflammation in various organs and leads to an increased risk of adverse health outcomes; therefore, how to prevent the toxic effects are of great concern to human. Alpha-lipoic acid (ALA) has anti-oxidant and anti-inflammatory activiti...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.991524/full |
| _version_ | 1811211071564808192 |
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| author | Xiaogang Luo Dongli Xie Tong Wu Wei Xu Qingyang Meng Kangli Cao Jianchen Hu |
| author_facet | Xiaogang Luo Dongli Xie Tong Wu Wei Xu Qingyang Meng Kangli Cao Jianchen Hu |
| author_sort | Xiaogang Luo |
| collection | DOAJ |
| description | Extensive exposure to nanomaterials causes oxidative stress and inflammation in various organs and leads to an increased risk of adverse health outcomes; therefore, how to prevent the toxic effects are of great concern to human. Alpha-lipoic acid (ALA) has anti-oxidant and anti-inflammatory activities, suggesting it may be effective to prevent nanomaterial-induced toxicity. However, the results obtained in individual studies remained controversial. We aimed to comprehensively evaluate the effects of ALA supplementation on nanomaterial-induced toxicity by performing a meta-analysis. Databases of PubMed, EMBASE, and Cochrane Library were searched up to May 2022. STATA 15.0 software was used for statistical analysis. Twelve studies were included. Meta-analysis of eight in vivo studies showed ALA supplementation could exert significant effects on nanomaterial-induced oxidative stress (by reducing MDA, ROS and increasing GSH, CAT, GPx, and SOD), inflammation (by downregulating NO, IgG, TNF-α, IL-6, and CRP), apoptosis (by activation of pro-apoptotic caspase-3), DNA damage (by a reduction in the tail length) and organ damage (by a decrease in the liver biomarker ALT and increases in brain neuron biomarker AChE and heart biomarker CPK). Pooled analysis of four in vitro studies indicated ALA intervention increased cell viability, decreased ROS levels, inhibited cell apoptosis and chelated metal ions. Subgroup analyses revealed changing the levels of GSH, IL-6, and metal ions were the main protective mechanisms of ALA supplementation because they were not changed by any subgroup factors. In conclusion, ALA supplementation may represent a potential strategy for the prevention of the toxicity induced by nanomaterials. |
| first_indexed | 2024-04-12T05:05:08Z |
| format | Article |
| id | doaj.art-b0db9cb4de564bfca8f927592c822dcc |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-12T05:05:08Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-b0db9cb4de564bfca8f927592c822dcc2022-12-22T03:46:53ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-09-01910.3389/fnut.2022.991524991524Evaluation of the protective roles of alpha-lipoic acid supplementation on nanomaterial-induced toxicity: A meta-analysis of in vitro and in vivo studiesXiaogang Luo0Dongli Xie1Tong Wu2Wei Xu3Qingyang Meng4Kangli Cao5Jianchen Hu6College of Textile and Clothing Engineering, Soochow University, Suzhou, ChinaCollege of Textile and Clothing Engineering, Soochow University, Suzhou, ChinaShanghai Jing Rui Yang Industrial Co., Ltd, Shanghai, ChinaShanghai Nutri-woods Bio-Technology Co., Ltd, Shanghai, ChinaShanghai Pechoin Daily Chemical Co., Ltd, Shanghai, ChinaShanghai Institute of Spacecraft Equipment, Shanghai, ChinaCollege of Textile and Clothing Engineering, Soochow University, Suzhou, ChinaExtensive exposure to nanomaterials causes oxidative stress and inflammation in various organs and leads to an increased risk of adverse health outcomes; therefore, how to prevent the toxic effects are of great concern to human. Alpha-lipoic acid (ALA) has anti-oxidant and anti-inflammatory activities, suggesting it may be effective to prevent nanomaterial-induced toxicity. However, the results obtained in individual studies remained controversial. We aimed to comprehensively evaluate the effects of ALA supplementation on nanomaterial-induced toxicity by performing a meta-analysis. Databases of PubMed, EMBASE, and Cochrane Library were searched up to May 2022. STATA 15.0 software was used for statistical analysis. Twelve studies were included. Meta-analysis of eight in vivo studies showed ALA supplementation could exert significant effects on nanomaterial-induced oxidative stress (by reducing MDA, ROS and increasing GSH, CAT, GPx, and SOD), inflammation (by downregulating NO, IgG, TNF-α, IL-6, and CRP), apoptosis (by activation of pro-apoptotic caspase-3), DNA damage (by a reduction in the tail length) and organ damage (by a decrease in the liver biomarker ALT and increases in brain neuron biomarker AChE and heart biomarker CPK). Pooled analysis of four in vitro studies indicated ALA intervention increased cell viability, decreased ROS levels, inhibited cell apoptosis and chelated metal ions. Subgroup analyses revealed changing the levels of GSH, IL-6, and metal ions were the main protective mechanisms of ALA supplementation because they were not changed by any subgroup factors. In conclusion, ALA supplementation may represent a potential strategy for the prevention of the toxicity induced by nanomaterials.https://www.frontiersin.org/articles/10.3389/fnut.2022.991524/fullnanomaterialsoxidative stressinflammationalpha-lipoic acidmeta-analysis |
| spellingShingle | Xiaogang Luo Dongli Xie Tong Wu Wei Xu Qingyang Meng Kangli Cao Jianchen Hu Evaluation of the protective roles of alpha-lipoic acid supplementation on nanomaterial-induced toxicity: A meta-analysis of in vitro and in vivo studies Frontiers in Nutrition nanomaterials oxidative stress inflammation alpha-lipoic acid meta-analysis |
| title | Evaluation of the protective roles of alpha-lipoic acid supplementation on nanomaterial-induced toxicity: A meta-analysis of in vitro and in vivo studies |
| title_full | Evaluation of the protective roles of alpha-lipoic acid supplementation on nanomaterial-induced toxicity: A meta-analysis of in vitro and in vivo studies |
| title_fullStr | Evaluation of the protective roles of alpha-lipoic acid supplementation on nanomaterial-induced toxicity: A meta-analysis of in vitro and in vivo studies |
| title_full_unstemmed | Evaluation of the protective roles of alpha-lipoic acid supplementation on nanomaterial-induced toxicity: A meta-analysis of in vitro and in vivo studies |
| title_short | Evaluation of the protective roles of alpha-lipoic acid supplementation on nanomaterial-induced toxicity: A meta-analysis of in vitro and in vivo studies |
| title_sort | evaluation of the protective roles of alpha lipoic acid supplementation on nanomaterial induced toxicity a meta analysis of in vitro and in vivo studies |
| topic | nanomaterials oxidative stress inflammation alpha-lipoic acid meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.991524/full |
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