Pathologic fracture and metastatic spinal cord compression in patients with prostate cancer and bone metastases
<p>Abstract</p> <p>Background</p> <p>The purpose of this study was to determine the risk factors for and incidence as well as prognostic impact of pathologic fracture (PF) and metastatic spinal cord compression (MSCC) in patients with bone metastases (BM) from prostate...
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| Format: | Article |
| Language: | English |
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BMC
2010-12-01
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| Series: | BMC Urology |
| Online Access: | http://www.biomedcentral.com/1471-2490/10/23 |
| _version_ | 1818067843792502784 |
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| author | Haukland Ellinor Nieder Carsten Pawinski Adam Dalhaug Astrid |
| author_facet | Haukland Ellinor Nieder Carsten Pawinski Adam Dalhaug Astrid |
| author_sort | Haukland Ellinor |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The purpose of this study was to determine the risk factors for and incidence as well as prognostic impact of pathologic fracture (PF) and metastatic spinal cord compression (MSCC) in patients with bone metastases (BM) from prostate cancer.</p> <p>Methods</p> <p>Retrospective cohort study including 61 consecutive patients seen at Nordland hospital's department of oncology between 2007 and 2009. The initial diagnosis of BM might have been made earlier. Twenty-nine patients (48%) received taxotere and 72% zoledronic acid after diagnosis of BM.</p> <p>Results</p> <p>Median actuarial survival after diagnosis of BM was 23 months. Six patients (10%) were alive at 5 years. Bone pain at baseline was present in 49% of patients. Eighty-nine percent required external beam radiotherapy and/or radioisotopes after diagnosis of BM. Seventeen patients (28%) developed at least one major skeletal complication, i.e. MSCC or PF (4 of them developed more than one). The actuarial risk was 44% at 4 and 5 years. Most events developed before treatment with zoledronic acid and/or taxotere. Median survival from diagnosis of either MSCC or PF was 11 months (5 months from MSCC). We did not identify statistically significant risk factors for development of major skeletal complications. Serum alkaline phosphatase above median value and age less than or equal to 70 years were the only risk factors approaching significance.</p> <p>Conclusions</p> <p>We found high rates of major skeletal complications in this unselected contemporary group of patients. Identification of risk factors might guide the development of early interventions aiming at prevention of MSCC and PF.</p> |
| first_indexed | 2024-12-10T15:30:08Z |
| format | Article |
| id | doaj.art-b0dccb05b05f40dabdc685edc1ed47cd |
| institution | Directory Open Access Journal |
| issn | 1471-2490 |
| language | English |
| last_indexed | 2024-12-10T15:30:08Z |
| publishDate | 2010-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Urology |
| spelling | doaj.art-b0dccb05b05f40dabdc685edc1ed47cd2022-12-22T01:43:25ZengBMCBMC Urology1471-24902010-12-011012310.1186/1471-2490-10-23Pathologic fracture and metastatic spinal cord compression in patients with prostate cancer and bone metastasesHaukland EllinorNieder CarstenPawinski AdamDalhaug Astrid<p>Abstract</p> <p>Background</p> <p>The purpose of this study was to determine the risk factors for and incidence as well as prognostic impact of pathologic fracture (PF) and metastatic spinal cord compression (MSCC) in patients with bone metastases (BM) from prostate cancer.</p> <p>Methods</p> <p>Retrospective cohort study including 61 consecutive patients seen at Nordland hospital's department of oncology between 2007 and 2009. The initial diagnosis of BM might have been made earlier. Twenty-nine patients (48%) received taxotere and 72% zoledronic acid after diagnosis of BM.</p> <p>Results</p> <p>Median actuarial survival after diagnosis of BM was 23 months. Six patients (10%) were alive at 5 years. Bone pain at baseline was present in 49% of patients. Eighty-nine percent required external beam radiotherapy and/or radioisotopes after diagnosis of BM. Seventeen patients (28%) developed at least one major skeletal complication, i.e. MSCC or PF (4 of them developed more than one). The actuarial risk was 44% at 4 and 5 years. Most events developed before treatment with zoledronic acid and/or taxotere. Median survival from diagnosis of either MSCC or PF was 11 months (5 months from MSCC). We did not identify statistically significant risk factors for development of major skeletal complications. Serum alkaline phosphatase above median value and age less than or equal to 70 years were the only risk factors approaching significance.</p> <p>Conclusions</p> <p>We found high rates of major skeletal complications in this unselected contemporary group of patients. Identification of risk factors might guide the development of early interventions aiming at prevention of MSCC and PF.</p>http://www.biomedcentral.com/1471-2490/10/23 |
| spellingShingle | Haukland Ellinor Nieder Carsten Pawinski Adam Dalhaug Astrid Pathologic fracture and metastatic spinal cord compression in patients with prostate cancer and bone metastases BMC Urology |
| title | Pathologic fracture and metastatic spinal cord compression in patients with prostate cancer and bone metastases |
| title_full | Pathologic fracture and metastatic spinal cord compression in patients with prostate cancer and bone metastases |
| title_fullStr | Pathologic fracture and metastatic spinal cord compression in patients with prostate cancer and bone metastases |
| title_full_unstemmed | Pathologic fracture and metastatic spinal cord compression in patients with prostate cancer and bone metastases |
| title_short | Pathologic fracture and metastatic spinal cord compression in patients with prostate cancer and bone metastases |
| title_sort | pathologic fracture and metastatic spinal cord compression in patients with prostate cancer and bone metastases |
| url | http://www.biomedcentral.com/1471-2490/10/23 |
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