SRT1720 Alleviates ANIT-Induced Cholestasis in a Mouse Model

SRT1720 Alleviates ANIT-Induced Cholestasis in a Mouse Model

Intrahepatic cholestasis is a kind of clinical syndrome along with hepatotoxicity which caused by intrahepatic and systemic accumulations of bile acid. There are several crucial generating factors of the pathogenesis of cholestasis, such as inflammation, dysregulation of bile acid transporters and o...

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Bibliographic Details
Main Authors: Linxi Yu, Xiaoxin Liu, Zihang Yuan, Xiaojiaoyang Li, Hang Yang, Ziqiao Yuan, Lixin Sun, Luyong Zhang, Zhengzhou Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Pharmacology
Subjects:
SRT1720
ANTI
cholestasis
FXR
Nrf2
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00256/full

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