Low-carbohydrate diet improves the cardiopsychiatry profile of patients with schizophrenia: A pilot study
Background and Objective: Patients with schizophrenia are more prone to develop metabolic syndrome (MetS) with its related complications, including cardiovascular diseases and diabetes mellitus compared to the general population. In this study, we aim to evaluate the effect of low-carbohydrate diet...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Heart and Mind |
| Subjects: | |
| Online Access: | http://www.heartmindjournal.org/article.asp?issn=2468-6476;year=2021;volume=5;issue=3;spage=80;epage=85;aulast=Altooq |
| _version_ | 1818734915656613888 |
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| author | Noor J Altooq Safa Abduljalil Aburowais Ahmed N Alajaimi Isa Y Albanna Omar A Alhaj Haitham A Jahrami |
| author_facet | Noor J Altooq Safa Abduljalil Aburowais Ahmed N Alajaimi Isa Y Albanna Omar A Alhaj Haitham A Jahrami |
| author_sort | Noor J Altooq |
| collection | DOAJ |
| description | Background and Objective: Patients with schizophrenia are more prone to develop metabolic syndrome (MetS) with its related complications, including cardiovascular diseases and diabetes mellitus compared to the general population. In this study, we aim to evaluate the effect of low-carbohydrate diet on MetS Z score, weight status, and symptomatology of patients with schizophrenia in Bahrain. Materials and Methods: This single-group pretest–posttest study was executed while considering an ethical approach of volunteer participants, a sample size of 35 patients with schizophrenia. The participants were instructed to follow a low-carbohydrate moderate-fat diet for 8 weeks. Anthropometric measurements, mean arterial pressure, basal metabolic index, body fat percentage (BFP), body surface area (BSA), and MetS Z score and Clinical Global Impression (CGI) Scale were collected before and after the diet intervention. Descriptive statistics, including the mean and standard deviations, were used for continuous variables and percentages for the categorical variables. Paired t-tests and effect size were used to analyze the mean difference of the values before and after the diet intervention. Results: A statistical significance in the mean difference was observed among the following variables: MetS Z score, weight, body mass index (BMI), high-density lipoproteins (HDL), low-density lipoprotein (LDL), thrombin generation test, waist circumference (WC), BFP, BSA, and CGI-improvement (CGI-I). Weight, BMI, TG, BFP, BSA, and CGI-I had a large effect size of the mean difference, whereas LDL, HDL, and WC had a moderate effect size. There was no statistically significant difference in the MetS Z score between male and female after the diet intervention (P = 0.274). Conclusion: Dietary modification with low-carbohydrates restriction is a workable approach in the management of schizophrenia and its related metabolic complications. Clinical trials need to be conducted to corroborate the implementation of dietary intervention as a co-treatment of schizophrenia. |
| first_indexed | 2024-12-18T00:12:57Z |
| format | Article |
| id | doaj.art-b0e1ee9a151b4800a9a338a843a0ac2d |
| institution | Directory Open Access Journal |
| issn | 2468-6476 2468-6484 |
| language | English |
| last_indexed | 2024-12-18T00:12:57Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Heart and Mind |
| spelling | doaj.art-b0e1ee9a151b4800a9a338a843a0ac2d2022-12-21T21:27:37ZengWolters Kluwer Medknow PublicationsHeart and Mind2468-64762468-64842021-01-0153808510.4103/hm.hm_25_21Low-carbohydrate diet improves the cardiopsychiatry profile of patients with schizophrenia: A pilot studyNoor J AltooqSafa Abduljalil AburowaisAhmed N AlajaimiIsa Y AlbannaOmar A AlhajHaitham A JahramiBackground and Objective: Patients with schizophrenia are more prone to develop metabolic syndrome (MetS) with its related complications, including cardiovascular diseases and diabetes mellitus compared to the general population. In this study, we aim to evaluate the effect of low-carbohydrate diet on MetS Z score, weight status, and symptomatology of patients with schizophrenia in Bahrain. Materials and Methods: This single-group pretest–posttest study was executed while considering an ethical approach of volunteer participants, a sample size of 35 patients with schizophrenia. The participants were instructed to follow a low-carbohydrate moderate-fat diet for 8 weeks. Anthropometric measurements, mean arterial pressure, basal metabolic index, body fat percentage (BFP), body surface area (BSA), and MetS Z score and Clinical Global Impression (CGI) Scale were collected before and after the diet intervention. Descriptive statistics, including the mean and standard deviations, were used for continuous variables and percentages for the categorical variables. Paired t-tests and effect size were used to analyze the mean difference of the values before and after the diet intervention. Results: A statistical significance in the mean difference was observed among the following variables: MetS Z score, weight, body mass index (BMI), high-density lipoproteins (HDL), low-density lipoprotein (LDL), thrombin generation test, waist circumference (WC), BFP, BSA, and CGI-improvement (CGI-I). Weight, BMI, TG, BFP, BSA, and CGI-I had a large effect size of the mean difference, whereas LDL, HDL, and WC had a moderate effect size. There was no statistically significant difference in the MetS Z score between male and female after the diet intervention (P = 0.274). Conclusion: Dietary modification with low-carbohydrates restriction is a workable approach in the management of schizophrenia and its related metabolic complications. Clinical trials need to be conducted to corroborate the implementation of dietary intervention as a co-treatment of schizophrenia.http://www.heartmindjournal.org/article.asp?issn=2468-6476;year=2021;volume=5;issue=3;spage=80;epage=85;aulast=Altooqlow-carbohydrate dietmetabolic syndromemets z scoreschizophrenia |
| spellingShingle | Noor J Altooq Safa Abduljalil Aburowais Ahmed N Alajaimi Isa Y Albanna Omar A Alhaj Haitham A Jahrami Low-carbohydrate diet improves the cardiopsychiatry profile of patients with schizophrenia: A pilot study Heart and Mind low-carbohydrate diet metabolic syndrome mets z score schizophrenia |
| title | Low-carbohydrate diet improves the cardiopsychiatry profile of patients with schizophrenia: A pilot study |
| title_full | Low-carbohydrate diet improves the cardiopsychiatry profile of patients with schizophrenia: A pilot study |
| title_fullStr | Low-carbohydrate diet improves the cardiopsychiatry profile of patients with schizophrenia: A pilot study |
| title_full_unstemmed | Low-carbohydrate diet improves the cardiopsychiatry profile of patients with schizophrenia: A pilot study |
| title_short | Low-carbohydrate diet improves the cardiopsychiatry profile of patients with schizophrenia: A pilot study |
| title_sort | low carbohydrate diet improves the cardiopsychiatry profile of patients with schizophrenia a pilot study |
| topic | low-carbohydrate diet metabolic syndrome mets z score schizophrenia |
| url | http://www.heartmindjournal.org/article.asp?issn=2468-6476;year=2021;volume=5;issue=3;spage=80;epage=85;aulast=Altooq |
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