THE EFFECTS OF 'PROFETAL' PREPARATION UPON FUNCTIONAL ACTIVITY OF HUMAN MONONUCLEAR LEUKOCYTES AND DENDRITIC CELLS
<p><strong>Abstract. </strong>The effects of 'Profetal', a drug containing liophylized, dextran-stabilized human alpha-fetoprotein as main active component, were investigated on peripheral donor blood mononuclear leukocytes (ML), with respect to their functional propertie...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | http://mimmun.ru/index.php/mimmun/article/view/619 |
| _version_ | 1827833273236062208 |
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| author | V. A. Chereshnev O. V. Lebedinskaya C. Yu. Rodionov N. K. Ahmatova I. Zh. Shubina E. A. Lebedinskaya T. V. Gavrilova M. V. Kisselevsky |
| author_facet | V. A. Chereshnev O. V. Lebedinskaya C. Yu. Rodionov N. K. Ahmatova I. Zh. Shubina E. A. Lebedinskaya T. V. Gavrilova M. V. Kisselevsky |
| author_sort | V. A. Chereshnev |
| collection | DOAJ |
| description | <p><strong>Abstract. </strong>The effects of 'Profetal', a drug containing liophylized, dextran-stabilized human alpha-fetoprotein as main active component, were investigated on peripheral donor blood mononuclear leukocytes (ML), with respect to their functional properties and the potential to generate mature dendritic cells (DC).</p><p>Addition of the drug to cell cultures at optimal doses was shown to cause significant increase in their proliferative capacity and ML blastic transformation levels, and enhanced cytotoxicity towards K562 tumor cells, as well as to induce maturation of antigen-presenting dendritic cells.</p><p>On the basis of the data obtained, a conclusion is made that 'Profetal' is an active immunomodulatory factor, and it may be applied for generation of cytotoxic lymphocytes and mature DC, aiming to apply them for the biotherapy of oncological and infectious diseases.</p> |
| first_indexed | 2024-03-12T05:26:56Z |
| format | Article |
| id | doaj.art-b0e1f4c12aa340f9a31b1aa7952c7f4c |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-03-12T05:26:56Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-b0e1f4c12aa340f9a31b1aa7952c7f4c2023-09-03T07:15:12ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0175–652553410.15789/1563-0625-2005-5–6-525-534616THE EFFECTS OF 'PROFETAL' PREPARATION UPON FUNCTIONAL ACTIVITY OF HUMAN MONONUCLEAR LEUKOCYTES AND DENDRITIC CELLSV. A. Chereshnev0O. V. Lebedinskaya1C. Yu. Rodionov2N. K. Ahmatova3I. Zh. Shubina4E. A. Lebedinskaya5T. V. Gavrilova6M. V. Kisselevsky7Институт иммунологии и физиологии УрО РАН, ЕкатеринбургГОУ ВПО «Пермская государственная медицинская академия» МЗ РЗ, ПермьФилиал Института иммунологии и физиологии УрО РАН, ПермьОнкологический научный центр им. Н.Н. Блохина РАМН, МоскваОнкологический научный центр им. Н.Н. Блохина РАМН, МоскваГОУ ВПО «Пермская государственная медицинская академия» МЗ РЗ, ПермьИнститут иммунологии и физиологии УрО РАН, ЕкатеринбургОнкологический научный центр им. Н.Н. Блохина РАМН, Москва<p><strong>Abstract. </strong>The effects of 'Profetal', a drug containing liophylized, dextran-stabilized human alpha-fetoprotein as main active component, were investigated on peripheral donor blood mononuclear leukocytes (ML), with respect to their functional properties and the potential to generate mature dendritic cells (DC).</p><p>Addition of the drug to cell cultures at optimal doses was shown to cause significant increase in their proliferative capacity and ML blastic transformation levels, and enhanced cytotoxicity towards K562 tumor cells, as well as to induce maturation of antigen-presenting dendritic cells.</p><p>On the basis of the data obtained, a conclusion is made that 'Profetal' is an active immunomodulatory factor, and it may be applied for generation of cytotoxic lymphocytes and mature DC, aiming to apply them for the biotherapy of oncological and infectious diseases.</p>http://mimmun.ru/index.php/mimmun/article/view/619Profetalα-fetoproteinmononuclear leukocytesdendritic cellsimmunophenotypefunctional activity |
| spellingShingle | V. A. Chereshnev O. V. Lebedinskaya C. Yu. Rodionov N. K. Ahmatova I. Zh. Shubina E. A. Lebedinskaya T. V. Gavrilova M. V. Kisselevsky THE EFFECTS OF 'PROFETAL' PREPARATION UPON FUNCTIONAL ACTIVITY OF HUMAN MONONUCLEAR LEUKOCYTES AND DENDRITIC CELLS Медицинская иммунология Profetal α-fetoprotein mononuclear leukocytes dendritic cells immunophenotype functional activity |
| title | THE EFFECTS OF 'PROFETAL' PREPARATION UPON FUNCTIONAL ACTIVITY OF HUMAN MONONUCLEAR LEUKOCYTES AND DENDRITIC CELLS |
| title_full | THE EFFECTS OF 'PROFETAL' PREPARATION UPON FUNCTIONAL ACTIVITY OF HUMAN MONONUCLEAR LEUKOCYTES AND DENDRITIC CELLS |
| title_fullStr | THE EFFECTS OF 'PROFETAL' PREPARATION UPON FUNCTIONAL ACTIVITY OF HUMAN MONONUCLEAR LEUKOCYTES AND DENDRITIC CELLS |
| title_full_unstemmed | THE EFFECTS OF 'PROFETAL' PREPARATION UPON FUNCTIONAL ACTIVITY OF HUMAN MONONUCLEAR LEUKOCYTES AND DENDRITIC CELLS |
| title_short | THE EFFECTS OF 'PROFETAL' PREPARATION UPON FUNCTIONAL ACTIVITY OF HUMAN MONONUCLEAR LEUKOCYTES AND DENDRITIC CELLS |
| title_sort | effects of profetal preparation upon functional activity of human mononuclear leukocytes and dendritic cells |
| topic | Profetal α-fetoprotein mononuclear leukocytes dendritic cells immunophenotype functional activity |
| url | http://mimmun.ru/index.php/mimmun/article/view/619 |
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