Correlation of Serum CA-125 and Progesterone Levels with Ultrasound Markers in The Prediction of Pregnancy Outcome in Threatened Miscarriage
Background The aim of this study was to evaluate the relationship between ultrasonographic findings and serum progesterone and cancer antigen-125 (CA-125) levels in threatened miscarriage and to predict pregnancy outcome. Materials and Methods In a prospective comparative case-control study, serum C...
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Royan Institute (ACECR), Tehran
2016-01-01
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| Series: | International Journal of Fertility and Sterility |
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| Online Access: | http://www.ijfs.ir/article_45342_a31acec5bf1a93e052c5fa3736bb5a41.pdf |
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| author | Maged Al Mohamady Ghada Abdel Fattah Eman Elkattan Rasha Bayoumy Dalia Ahmed Hamed |
| author_facet | Maged Al Mohamady Ghada Abdel Fattah Eman Elkattan Rasha Bayoumy Dalia Ahmed Hamed |
| author_sort | Maged Al Mohamady |
| collection | DOAJ |
| description | Background The aim of this study was to evaluate the relationship between ultrasonographic findings and serum progesterone and cancer antigen-125 (CA-125) levels in threatened miscarriage and to predict pregnancy outcome. Materials and Methods In a prospective comparative case-control study, serum CA-125 and progesterone levels were measured for 100 pregnant women with threatened miscarriage who attended the outpatient clinic or the causality department of Obstetrics and Gynecology at Kasr El-Aini Hospital, Giza, Egypt, during the period from March 2013 to October 2013. Ultrasound was performed for fetal viability, crown-rump length (CRL), gestational sac diameter (GSD) and fetal heart rate (FHR). The patients were followed up and divided into two groups based on the outcome: 20 women who miscarried (group 1), and 80 women who continued pregnancy (group 2). The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and overall accuracy were tested for CA-125 and progesterone levels in prediction of the pregnancy outcome. Correlation of these chemical markers with the ultrasound markers was also examined. Results In the group that miscarried, CA-125 level was significantly higher (P < 0.001) and serum progesterone level was significantly lower (P < 0.001). For prediction of the outcome of pregnancy, the cut-off limit of 31.2 IU/ml for CA-125 level yielded sensitivity, specificity and an overall accuracy of 96.2, 100 and 99.4% respectively. The cut-off limit of 11.5 ng/ml for progesterone level yielded sensitivity, specificity and an overall accuracy of 97.5, 100 and 99.8% respectively. CA-125 level had a negative correlation with progesterone level and FHR levels (r=-0.716, P < 0.001) and (r=-0.414, P < 0.001) respectively. Serum progesterone level correlated with GSD (r=0.521, P < 0.001) and with CRL (r=0.407, P < 0.001) and FHR (r=0.363, P < 0.001). CA-125 level was significantly higher in the group that showed hematoma as compared with the group without hematoma (P < 0.001). Also, serum progesterone level was significantly lower in the group that showed hematoma as compared with the group without hematoma (P=0.017). Conclusion Serum CA-125 and progesterone levels are valid early predictors of the outcome of pregnancy in women with threatened miscarriage. They are correlated with some ultrasonographic markers (GSD, CRL, and FHR). |
| first_indexed | 2024-12-11T04:13:51Z |
| format | Article |
| id | doaj.art-b0e3700243dd4aafafc5e871d4319edd |
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| issn | 2008-076X 2008-0778 |
| language | English |
| last_indexed | 2024-12-11T04:13:51Z |
| publishDate | 2016-01-01 |
| publisher | Royan Institute (ACECR), Tehran |
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| series | International Journal of Fertility and Sterility |
| spelling | doaj.art-b0e3700243dd4aafafc5e871d4319edd2022-12-22T01:21:19ZengRoyan Institute (ACECR), TehranInternational Journal of Fertility and Sterility2008-076X2008-07782016-01-019450651110.22074/ijfs.2016.460945342Correlation of Serum CA-125 and Progesterone Levels with Ultrasound Markers in The Prediction of Pregnancy Outcome in Threatened MiscarriageMaged Al Mohamady0Ghada Abdel Fattah1Eman Elkattan2Rasha Bayoumy3Dalia Ahmed Hamed4Departement of Obstetrics and Gynecology, Cairo University, Giza, EgyptDepartement of Obstetrics and Gynecology, Cairo University, Giza, EgyptDepartement of Obstetrics and Gynecology, Cairo University, Giza, EgyptDepartement of Obstetrics and Gynecology, Cairo University, Giza, EgyptDepartment of Chemical Pathology, Cairo University, Giza, EgyptBackground The aim of this study was to evaluate the relationship between ultrasonographic findings and serum progesterone and cancer antigen-125 (CA-125) levels in threatened miscarriage and to predict pregnancy outcome. Materials and Methods In a prospective comparative case-control study, serum CA-125 and progesterone levels were measured for 100 pregnant women with threatened miscarriage who attended the outpatient clinic or the causality department of Obstetrics and Gynecology at Kasr El-Aini Hospital, Giza, Egypt, during the period from March 2013 to October 2013. Ultrasound was performed for fetal viability, crown-rump length (CRL), gestational sac diameter (GSD) and fetal heart rate (FHR). The patients were followed up and divided into two groups based on the outcome: 20 women who miscarried (group 1), and 80 women who continued pregnancy (group 2). The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and overall accuracy were tested for CA-125 and progesterone levels in prediction of the pregnancy outcome. Correlation of these chemical markers with the ultrasound markers was also examined. Results In the group that miscarried, CA-125 level was significantly higher (P < 0.001) and serum progesterone level was significantly lower (P < 0.001). For prediction of the outcome of pregnancy, the cut-off limit of 31.2 IU/ml for CA-125 level yielded sensitivity, specificity and an overall accuracy of 96.2, 100 and 99.4% respectively. The cut-off limit of 11.5 ng/ml for progesterone level yielded sensitivity, specificity and an overall accuracy of 97.5, 100 and 99.8% respectively. CA-125 level had a negative correlation with progesterone level and FHR levels (r=-0.716, P < 0.001) and (r=-0.414, P < 0.001) respectively. Serum progesterone level correlated with GSD (r=0.521, P < 0.001) and with CRL (r=0.407, P < 0.001) and FHR (r=0.363, P < 0.001). CA-125 level was significantly higher in the group that showed hematoma as compared with the group without hematoma (P < 0.001). Also, serum progesterone level was significantly lower in the group that showed hematoma as compared with the group without hematoma (P=0.017). Conclusion Serum CA-125 and progesterone levels are valid early predictors of the outcome of pregnancy in women with threatened miscarriage. They are correlated with some ultrasonographic markers (GSD, CRL, and FHR).http://www.ijfs.ir/article_45342_a31acec5bf1a93e052c5fa3736bb5a41.pdffirst trimesterultrasoundca125progesteronethreatened miscarriage |
| spellingShingle | Maged Al Mohamady Ghada Abdel Fattah Eman Elkattan Rasha Bayoumy Dalia Ahmed Hamed Correlation of Serum CA-125 and Progesterone Levels with Ultrasound Markers in The Prediction of Pregnancy Outcome in Threatened Miscarriage International Journal of Fertility and Sterility first trimester ultrasound ca 125 progesterone threatened miscarriage |
| title | Correlation of Serum CA-125 and Progesterone Levels with Ultrasound Markers in The Prediction of Pregnancy Outcome in Threatened Miscarriage |
| title_full | Correlation of Serum CA-125 and Progesterone Levels with Ultrasound Markers in The Prediction of Pregnancy Outcome in Threatened Miscarriage |
| title_fullStr | Correlation of Serum CA-125 and Progesterone Levels with Ultrasound Markers in The Prediction of Pregnancy Outcome in Threatened Miscarriage |
| title_full_unstemmed | Correlation of Serum CA-125 and Progesterone Levels with Ultrasound Markers in The Prediction of Pregnancy Outcome in Threatened Miscarriage |
| title_short | Correlation of Serum CA-125 and Progesterone Levels with Ultrasound Markers in The Prediction of Pregnancy Outcome in Threatened Miscarriage |
| title_sort | correlation of serum ca 125 and progesterone levels with ultrasound markers in the prediction of pregnancy outcome in threatened miscarriage |
| topic | first trimester ultrasound ca 125 progesterone threatened miscarriage |
| url | http://www.ijfs.ir/article_45342_a31acec5bf1a93e052c5fa3736bb5a41.pdf |
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