Antioxidant Effects of Some Drugs on Ethanol-induced Ulcers
The aim of this work was to investigate the antioxidant potential of some commonly used drugs (bromocriptine, haloperidol and azithromycin) on alcohol-induced ulcers in the rat. The following parameters were determined: content of reduced glutathione, activities of catalase, xanthine oxidase, glutat...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2009-02-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/14/2/816/ |
| _version_ | 1811297901748420608 |
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| author | Svetlana Trivic Julijana Rasic Biljana Kaurinovic Snezana Janicijevic-Hudomal Mira Popovic |
| author_facet | Svetlana Trivic Julijana Rasic Biljana Kaurinovic Snezana Janicijevic-Hudomal Mira Popovic |
| author_sort | Svetlana Trivic |
| collection | DOAJ |
| description | The aim of this work was to investigate the antioxidant potential of some commonly used drugs (bromocriptine, haloperidol and azithromycin) on alcohol-induced ulcers in the rat. The following parameters were determined: content of reduced glutathione, activities of catalase, xanthine oxidase, glutathione reductase, glutathione peroxidase, peroxidase, and lipid peroxidation intensity. A battery of biochemical assays were used and the resulting data was statistically analyzed. Alcohol stress caused gastric ulcerations and hemorrhages and changed all the examined parameters except glutathione peroxidase activity. All drugs reduced the ulcer index and hemorrhages, with azithromycin showing the strongest effects. The drugs in combination with alcohol showed different effects on biochemical parameters. Our results indicate that the gastroprotective effects of the investigated drugs on experimental lesions induced by 100% ethanol could not be correlated with their antioxidative properties. |
| first_indexed | 2024-04-13T06:11:02Z |
| format | Article |
| id | doaj.art-b0e38a7a6a0444608fd0d24446483ab7 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-13T06:11:02Z |
| publishDate | 2009-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-b0e38a7a6a0444608fd0d24446483ab72022-12-22T02:59:03ZengMDPI AGMolecules1420-30492009-02-0114281682610.3390/molecules14020816Antioxidant Effects of Some Drugs on Ethanol-induced UlcersSvetlana TrivicJulijana RasicBiljana KaurinovicSnezana Janicijevic-HudomalMira PopovicThe aim of this work was to investigate the antioxidant potential of some commonly used drugs (bromocriptine, haloperidol and azithromycin) on alcohol-induced ulcers in the rat. The following parameters were determined: content of reduced glutathione, activities of catalase, xanthine oxidase, glutathione reductase, glutathione peroxidase, peroxidase, and lipid peroxidation intensity. A battery of biochemical assays were used and the resulting data was statistically analyzed. Alcohol stress caused gastric ulcerations and hemorrhages and changed all the examined parameters except glutathione peroxidase activity. All drugs reduced the ulcer index and hemorrhages, with azithromycin showing the strongest effects. The drugs in combination with alcohol showed different effects on biochemical parameters. Our results indicate that the gastroprotective effects of the investigated drugs on experimental lesions induced by 100% ethanol could not be correlated with their antioxidative properties.http://www.mdpi.com/1420-3049/14/2/816/Alcohol stressStomachBromocriptineHaloperidolAzithromycinAntioxidative status |
| spellingShingle | Svetlana Trivic Julijana Rasic Biljana Kaurinovic Snezana Janicijevic-Hudomal Mira Popovic Antioxidant Effects of Some Drugs on Ethanol-induced Ulcers Molecules Alcohol stress Stomach Bromocriptine Haloperidol Azithromycin Antioxidative status |
| title | Antioxidant Effects of Some Drugs on Ethanol-induced Ulcers |
| title_full | Antioxidant Effects of Some Drugs on Ethanol-induced Ulcers |
| title_fullStr | Antioxidant Effects of Some Drugs on Ethanol-induced Ulcers |
| title_full_unstemmed | Antioxidant Effects of Some Drugs on Ethanol-induced Ulcers |
| title_short | Antioxidant Effects of Some Drugs on Ethanol-induced Ulcers |
| title_sort | antioxidant effects of some drugs on ethanol induced ulcers |
| topic | Alcohol stress Stomach Bromocriptine Haloperidol Azithromycin Antioxidative status |
| url | http://www.mdpi.com/1420-3049/14/2/816/ |
| work_keys_str_mv | AT svetlanatrivic antioxidanteffectsofsomedrugsonethanolinducedulcers AT julijanarasic antioxidanteffectsofsomedrugsonethanolinducedulcers AT biljanakaurinovic antioxidanteffectsofsomedrugsonethanolinducedulcers AT snezanajanicijevichudomal antioxidanteffectsofsomedrugsonethanolinducedulcers AT mirapopovic antioxidanteffectsofsomedrugsonethanolinducedulcers |