Effects of taxifolin from enzymatic hydrolysis of Rhododendron mucrotulatum on hair growth promotion
Flavonoid aglycones possess biological activities, such as antioxidant and antidiabetic activities compared to glycosides. Taxifolin, a flavonoid aglycones, is detected only in trace amounts in nature and is not easily observed. Therefore, in this study, to investigate the hair tonic and hair loss i...
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.995238/full |
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| author | Sun-Min Park Yi-Chang He Yi-Chang He Chun Gong Wei Gao Young-Soo Bae Young-Soo Bae Chuanling Si Kwang-Hyun Park Kwang-Hyun Park Sun-Eun Choi |
| author_facet | Sun-Min Park Yi-Chang He Yi-Chang He Chun Gong Wei Gao Young-Soo Bae Young-Soo Bae Chuanling Si Kwang-Hyun Park Kwang-Hyun Park Sun-Eun Choi |
| author_sort | Sun-Min Park |
| collection | DOAJ |
| description | Flavonoid aglycones possess biological activities, such as antioxidant and antidiabetic activities compared to glycosides. Taxifolin, a flavonoid aglycones, is detected only in trace amounts in nature and is not easily observed. Therefore, in this study, to investigate the hair tonic and hair loss inhibitors effect of taxifolin, high content of taxifolin aglycone extract was prepared by enzymatic hydrolysis. Taxifolin effectively regulates the apoptosis of dermal papilla cells, which is associated with hair loss, based on its strong antioxidant activities. However, inhibition of dihydrotestosterone (DHT), which is a major cause of male pattern hair loss, was significantly reduced with taxifolin treatment compared with minoxidil, as a positive control. It was also confirmed that a representative factor for promoting hair growth, IGF-1, was significantly increased, and that TGF-β1, a representative biomarker for hair loss, was significantly reduced with taxifolin treatment. These results suggest that taxifolin from enzymatic hydrolysis of RM is a potential treatment for hair loss and a hair growth enhancer. |
| first_indexed | 2024-04-12T23:31:44Z |
| format | Article |
| id | doaj.art-b0e473398a5f4a54a17f0474f7467485 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-12T23:31:44Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-b0e473398a5f4a54a17f0474f74674852022-12-22T03:12:16ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-09-011010.3389/fbioe.2022.995238995238Effects of taxifolin from enzymatic hydrolysis of Rhododendron mucrotulatum on hair growth promotionSun-Min Park0Yi-Chang He1Yi-Chang He2Chun Gong3Wei Gao4Young-Soo Bae5Young-Soo Bae6Chuanling Si7Kwang-Hyun Park8Kwang-Hyun Park9Sun-Eun Choi10Department of Forest Biomaterials Engineering, College of Forest and Environmental Sciences, Kangwon National University, Kangwon, South KoreaKey Lab of Agricultural Resources and Ecology of Poyang Lake Basin, College of Land Resources and Environment, Jiangxi Agricultural University, Nanchang, Jiangxi, ChinaJiangxi Academy of Forestry, Nanchang, Jiangxi, ChinaJiangxi Academy of Forestry, Nanchang, Jiangxi, ChinaJiangxi Academy of Forestry, Nanchang, Jiangxi, ChinaDepartment of Forest Biomaterials Engineering, College of Forest and Environmental Sciences, Kangwon National University, Kangwon, South KoreaJiangxi Academy of Forestry, Nanchang, Jiangxi, ChinaTianjin Key Laboratory of Pulp and Paper, Tianjin University of Science and Technology, Tianjin, ChinaDepartment of Emergency Medicine and BioMedical Science Graduate Program (BMSGP), Chonnam National University, Hwasun, South KoreaDepartment of Emergency Medical Rescue, Nambu University, Gwangju, South KoreaDepartment of Forest Biomaterials Engineering, College of Forest and Environmental Sciences, Kangwon National University, Kangwon, South KoreaFlavonoid aglycones possess biological activities, such as antioxidant and antidiabetic activities compared to glycosides. Taxifolin, a flavonoid aglycones, is detected only in trace amounts in nature and is not easily observed. Therefore, in this study, to investigate the hair tonic and hair loss inhibitors effect of taxifolin, high content of taxifolin aglycone extract was prepared by enzymatic hydrolysis. Taxifolin effectively regulates the apoptosis of dermal papilla cells, which is associated with hair loss, based on its strong antioxidant activities. However, inhibition of dihydrotestosterone (DHT), which is a major cause of male pattern hair loss, was significantly reduced with taxifolin treatment compared with minoxidil, as a positive control. It was also confirmed that a representative factor for promoting hair growth, IGF-1, was significantly increased, and that TGF-β1, a representative biomarker for hair loss, was significantly reduced with taxifolin treatment. These results suggest that taxifolin from enzymatic hydrolysis of RM is a potential treatment for hair loss and a hair growth enhancer.https://www.frontiersin.org/articles/10.3389/fbioe.2022.995238/fullRhododendron mucrotulatumtaxifolinenzyme hydrolysisdihydrotestosteronehuman follicle dermal papilla cells |
| spellingShingle | Sun-Min Park Yi-Chang He Yi-Chang He Chun Gong Wei Gao Young-Soo Bae Young-Soo Bae Chuanling Si Kwang-Hyun Park Kwang-Hyun Park Sun-Eun Choi Effects of taxifolin from enzymatic hydrolysis of Rhododendron mucrotulatum on hair growth promotion Frontiers in Bioengineering and Biotechnology Rhododendron mucrotulatum taxifolin enzyme hydrolysis dihydrotestosterone human follicle dermal papilla cells |
| title | Effects of taxifolin from enzymatic hydrolysis of Rhododendron mucrotulatum on hair growth promotion |
| title_full | Effects of taxifolin from enzymatic hydrolysis of Rhododendron mucrotulatum on hair growth promotion |
| title_fullStr | Effects of taxifolin from enzymatic hydrolysis of Rhododendron mucrotulatum on hair growth promotion |
| title_full_unstemmed | Effects of taxifolin from enzymatic hydrolysis of Rhododendron mucrotulatum on hair growth promotion |
| title_short | Effects of taxifolin from enzymatic hydrolysis of Rhododendron mucrotulatum on hair growth promotion |
| title_sort | effects of taxifolin from enzymatic hydrolysis of rhododendron mucrotulatum on hair growth promotion |
| topic | Rhododendron mucrotulatum taxifolin enzyme hydrolysis dihydrotestosterone human follicle dermal papilla cells |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.995238/full |
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