Mutational spectrum and prognosis in Chinese patients with prefibrotic primary myelofibrosis
Abstract Prefibrotic primary myelofibrosis (Pre‐PMF) has been classified as a separate entity of myeloproliferative neoplasms (MPNs). Pre‐PMF is clinically heterogeneous but a specific prognostic model is lacking. Gene mutations have emerged as useful tools for stratification of myelofibrosis patien...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-02-01
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| Series: | eJHaem |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jha2.361 |
| _version_ | 1828716135101497344 |
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| author | Chi‐Keung Cheng Jennifer W. Y. Lai Yuk‐Lin Yung Hoi‐Yun Chan Raymond S. M. Wong Natalie P. H. Chan Joyce S. Cheung Xi Luo Herbert‐Augustus Pitts Margaret H. L. Ng |
| author_facet | Chi‐Keung Cheng Jennifer W. Y. Lai Yuk‐Lin Yung Hoi‐Yun Chan Raymond S. M. Wong Natalie P. H. Chan Joyce S. Cheung Xi Luo Herbert‐Augustus Pitts Margaret H. L. Ng |
| author_sort | Chi‐Keung Cheng |
| collection | DOAJ |
| description | Abstract Prefibrotic primary myelofibrosis (Pre‐PMF) has been classified as a separate entity of myeloproliferative neoplasms (MPNs). Pre‐PMF is clinically heterogeneous but a specific prognostic model is lacking. Gene mutations have emerged as useful tools for stratification of myelofibrosis patients. However, there have been limited studies comprehensively investigating the mutational spectrum and its clinicopathological significance in pre‐PMF subjects. In this study, we addressed these issues by profiling the mutation status of 141 genes in 172 Chinese MPN patients including 72 pre‐PMF cases. Our findings corroborated the clinical/molecular distinctiveness of pre‐PMF and suggested a refined risk classification strategy for this entity. |
| first_indexed | 2024-03-12T14:06:55Z |
| format | Article |
| id | doaj.art-b0e4e21176b34979a6eda4a1d1430a6e |
| institution | Directory Open Access Journal |
| issn | 2688-6146 |
| language | English |
| last_indexed | 2024-03-12T14:06:55Z |
| publishDate | 2022-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | eJHaem |
| spelling | doaj.art-b0e4e21176b34979a6eda4a1d1430a6e2023-08-21T14:05:38ZengWileyeJHaem2688-61462022-02-013118419010.1002/jha2.361Mutational spectrum and prognosis in Chinese patients with prefibrotic primary myelofibrosisChi‐Keung Cheng0Jennifer W. Y. Lai1Yuk‐Lin Yung2Hoi‐Yun Chan3Raymond S. M. Wong4Natalie P. H. Chan5Joyce S. Cheung6Xi Luo7Herbert‐Augustus Pitts8Margaret H. L. Ng9Blood Cancer Cytogenetics and Genomics Laboratory Department of Anatomical and Cellular Pathology Prince of Wales Hospital The Chinese University of Hong Kong Hong Kong ChinaDepartment of Medicine and Therapeutics, Prince of Wales Hospital The Chinese University of Hong Kong Hong Kong ChinaBlood Cancer Cytogenetics and Genomics Laboratory Department of Anatomical and Cellular Pathology Prince of Wales Hospital The Chinese University of Hong Kong Hong Kong ChinaBlood Cancer Cytogenetics and Genomics Laboratory Department of Anatomical and Cellular Pathology Prince of Wales Hospital The Chinese University of Hong Kong Hong Kong ChinaDepartment of Medicine and Therapeutics, Prince of Wales Hospital The Chinese University of Hong Kong Hong Kong ChinaBlood Cancer Cytogenetics and Genomics Laboratory Department of Anatomical and Cellular Pathology Prince of Wales Hospital The Chinese University of Hong Kong Hong Kong ChinaBlood Cancer Cytogenetics and Genomics Laboratory Department of Anatomical and Cellular Pathology Prince of Wales Hospital The Chinese University of Hong Kong Hong Kong ChinaBlood Cancer Cytogenetics and Genomics Laboratory Department of Anatomical and Cellular Pathology Prince of Wales Hospital The Chinese University of Hong Kong Hong Kong ChinaBlood Cancer Cytogenetics and Genomics Laboratory Department of Anatomical and Cellular Pathology Prince of Wales Hospital The Chinese University of Hong Kong Hong Kong ChinaBlood Cancer Cytogenetics and Genomics Laboratory Department of Anatomical and Cellular Pathology Prince of Wales Hospital The Chinese University of Hong Kong Hong Kong ChinaAbstract Prefibrotic primary myelofibrosis (Pre‐PMF) has been classified as a separate entity of myeloproliferative neoplasms (MPNs). Pre‐PMF is clinically heterogeneous but a specific prognostic model is lacking. Gene mutations have emerged as useful tools for stratification of myelofibrosis patients. However, there have been limited studies comprehensively investigating the mutational spectrum and its clinicopathological significance in pre‐PMF subjects. In this study, we addressed these issues by profiling the mutation status of 141 genes in 172 Chinese MPN patients including 72 pre‐PMF cases. Our findings corroborated the clinical/molecular distinctiveness of pre‐PMF and suggested a refined risk classification strategy for this entity.https://doi.org/10.1002/jha2.361myeloproliferative neoplasmsprefibrotic primary myelofibrosisprognostic factorsRUNX1TP53 |
| spellingShingle | Chi‐Keung Cheng Jennifer W. Y. Lai Yuk‐Lin Yung Hoi‐Yun Chan Raymond S. M. Wong Natalie P. H. Chan Joyce S. Cheung Xi Luo Herbert‐Augustus Pitts Margaret H. L. Ng Mutational spectrum and prognosis in Chinese patients with prefibrotic primary myelofibrosis eJHaem myeloproliferative neoplasms prefibrotic primary myelofibrosis prognostic factors RUNX1 TP53 |
| title | Mutational spectrum and prognosis in Chinese patients with prefibrotic primary myelofibrosis |
| title_full | Mutational spectrum and prognosis in Chinese patients with prefibrotic primary myelofibrosis |
| title_fullStr | Mutational spectrum and prognosis in Chinese patients with prefibrotic primary myelofibrosis |
| title_full_unstemmed | Mutational spectrum and prognosis in Chinese patients with prefibrotic primary myelofibrosis |
| title_short | Mutational spectrum and prognosis in Chinese patients with prefibrotic primary myelofibrosis |
| title_sort | mutational spectrum and prognosis in chinese patients with prefibrotic primary myelofibrosis |
| topic | myeloproliferative neoplasms prefibrotic primary myelofibrosis prognostic factors RUNX1 TP53 |
| url | https://doi.org/10.1002/jha2.361 |
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