Which antipsychotics can we use for obsessive-compulsive symptoms in schizophrenia?
Introduction Obsessive-compulsive symptoms (OCS) are common in schizophrenia, with a prevalence ranging from 12 to 25%. They affect negatively disease outcome. Patients with comorbid OCS present more frequently resistant psychotic symptoms. Besides, the appearance and aggravation of OSC are more c...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2021-04-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933821017107/type/journal_article |
| _version_ | 1797617296051535872 |
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| author | A. Aissa H. Ghabi D. Khattech S. Meddouri U. Ouali F. Nacef |
| author_facet | A. Aissa H. Ghabi D. Khattech S. Meddouri U. Ouali F. Nacef |
| author_sort | A. Aissa |
| collection | DOAJ |
| description |
Introduction
Obsessive-compulsive symptoms (OCS) are common in schizophrenia, with a prevalence ranging from 12 to 25%. They affect negatively disease outcome. Patients with comorbid OCS present more frequently resistant psychotic symptoms. Besides, the appearance and aggravation of OSC are more commonly reported with atypical antipsychotics.
Objectives
To present through a clinical case and a brief literature review the treatment challenge of obsessive-compulsive symptoms in schizophrenia.
Methods
We reported the case of Mr. M.S., treated in our department since 2008 for comorbid schizophrenia and OCS, and discussed therapeutic alternatives through a literature review.
Results
Mr. M.S. a 34-year-old male diagnosed with comorbid schizophrenia and OCS at age 20. To control psychotic symptoms, the patient received several trials of anti-psychotics with little improvement. We concluded that it was resistant schizophrenia. The introduction of clozapine reaching 300 mg daily led to significant improvement of psychotic symptoms but worsened OCS. The adjunction of fluoxetine and cognitive-behavioral therapy (CBT) was unsuccessful to manage obsessive symptoms. We opted for the association of aripiprazole 20 mg daily and clozapine, the doses of which were gradually tapered down to 150 mg daily. This association has guaranteed the improvement of both psychotic and obsessive symptoms.
Conclusions
Conclusion This clinical vignette highlights the need for clinical awareness about the possible exacerbation of OCS with atypical antipsychotics in schizophrenia.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:53:48Z |
| format | Article |
| id | doaj.art-b0e4fb50aabb4051a4cb2f1558df4c8d |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:53:48Z |
| publishDate | 2021-04-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-b0e4fb50aabb4051a4cb2f1558df4c8d2023-11-17T05:06:17ZengCambridge University PressEuropean Psychiatry0924-93381778-35852021-04-0164S644S64410.1192/j.eurpsy.2021.1710Which antipsychotics can we use for obsessive-compulsive symptoms in schizophrenia?A. Aissa0H. Ghabi1D. Khattech2S. Meddouri3U. Ouali4F. Nacef5Psychiatry A, Razi Hospital, Manouba, TunisiaPsychiatry A, Razi Hospital, Manouba, TunisiaPsychiatry A, Razi Hospital, Manouba, TunisiaPsychiatry A, Razi Hospital, Manouba, TunisiaPsychiatry A Department, Razi Hospital, Manouba, TunisiaPsychiatry A Department, Razi Hospital, Manouba, Tunisia Introduction Obsessive-compulsive symptoms (OCS) are common in schizophrenia, with a prevalence ranging from 12 to 25%. They affect negatively disease outcome. Patients with comorbid OCS present more frequently resistant psychotic symptoms. Besides, the appearance and aggravation of OSC are more commonly reported with atypical antipsychotics. Objectives To present through a clinical case and a brief literature review the treatment challenge of obsessive-compulsive symptoms in schizophrenia. Methods We reported the case of Mr. M.S., treated in our department since 2008 for comorbid schizophrenia and OCS, and discussed therapeutic alternatives through a literature review. Results Mr. M.S. a 34-year-old male diagnosed with comorbid schizophrenia and OCS at age 20. To control psychotic symptoms, the patient received several trials of anti-psychotics with little improvement. We concluded that it was resistant schizophrenia. The introduction of clozapine reaching 300 mg daily led to significant improvement of psychotic symptoms but worsened OCS. The adjunction of fluoxetine and cognitive-behavioral therapy (CBT) was unsuccessful to manage obsessive symptoms. We opted for the association of aripiprazole 20 mg daily and clozapine, the doses of which were gradually tapered down to 150 mg daily. This association has guaranteed the improvement of both psychotic and obsessive symptoms. Conclusions Conclusion This clinical vignette highlights the need for clinical awareness about the possible exacerbation of OCS with atypical antipsychotics in schizophrenia. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933821017107/type/journal_articlecomorbidityatypical antipsychoticsObsessive-compulsive symptomsschizophrénia |
| spellingShingle | A. Aissa H. Ghabi D. Khattech S. Meddouri U. Ouali F. Nacef Which antipsychotics can we use for obsessive-compulsive symptoms in schizophrenia? European Psychiatry comorbidity atypical antipsychotics Obsessive-compulsive symptoms schizophrénia |
| title | Which antipsychotics can we use for obsessive-compulsive symptoms in schizophrenia? |
| title_full | Which antipsychotics can we use for obsessive-compulsive symptoms in schizophrenia? |
| title_fullStr | Which antipsychotics can we use for obsessive-compulsive symptoms in schizophrenia? |
| title_full_unstemmed | Which antipsychotics can we use for obsessive-compulsive symptoms in schizophrenia? |
| title_short | Which antipsychotics can we use for obsessive-compulsive symptoms in schizophrenia? |
| title_sort | which antipsychotics can we use for obsessive compulsive symptoms in schizophrenia |
| topic | comorbidity atypical antipsychotics Obsessive-compulsive symptoms schizophrénia |
| url | https://www.cambridge.org/core/product/identifier/S0924933821017107/type/journal_article |
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