Abstract P-15: Structural Insights of Dirithromycin Binding to the Bacterial Ribosome

Abstract P-15: Structural Insights of Dirithromycin Binding to the Bacterial Ribosome

Background: Macrolide antibiotics bind in the nascent peptide exit tunnel (NPET) of the bacterial ribosome near the peptidyl transferase center. One of the second-generation macrolides, dirithromycin (DIR), differs from the parent erythromycin (ERY) by the presence of a hydrophobic (2-methoxyethoxy)...

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Bibliographic Details
Main Authors: Evgeny Pichkur, Pavel Kasatsky, Alena Paleskava, Alexander Myasnikov, Yury Polikanov, Ilya A. Osterman, Andrey Konevega
Format: Article
Language:English
Published: International Medical Research and Development Corporation 2019-06-01
Series:International Journal of Biomedicine
Subjects:
ribosome
antibiotics
structure
cryo-EM
Online Access:http://ijbm.org/articles/IJBM_2019_9_S1_P15.pdf

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