Nanoparticles from Gantrez-based conjugates for the oral delivery of camptothecin

Nanoparticles from Gantrez-based conjugates for the oral delivery of camptothecin

Camptothecin (CPT) exhibits a number of challenges for its oral administration, including a low aqueous solubility, a lactone ring susceptible to hydrolysis, and an affinity to the intestinal P-gp. The aim of this work was to evaluate nanoparticles from Gantrez-based conjugates as carriers for the o...

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Bibliographic Details
Main Authors: Judit Huarte, Socorro Espuelas, Cristina Martínez-Oharriz, Juan M. Irache
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:International Journal of Pharmaceutics: X
Subjects:
Camptothecin
Nanoparticles
Oral delivery
Conjugates
Cyclodextrin
Poly(ethylene glycol)
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156721000335

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