Smart Polymeric Micelles for Anticancer Hydrophobic Drugs
Cancer has become one of the deadliest diseases in our society. Surgery accompanied by subsequent chemotherapy is the treatment most used to prolong or save the patient’s life. Still, it carries secondary risks such as infections and thrombosis and causes cytotoxic effects in healthy tissues. Using...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/1/4 |
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| author | Andy Guzmán Rodríguez Marquiza Sablón Carrazana Chrislayne Rodríguez Tanty Martijn J. A. Malessy Gastón Fuentes Luis J. Cruz |
| author_facet | Andy Guzmán Rodríguez Marquiza Sablón Carrazana Chrislayne Rodríguez Tanty Martijn J. A. Malessy Gastón Fuentes Luis J. Cruz |
| author_sort | Andy Guzmán Rodríguez |
| collection | DOAJ |
| description | Cancer has become one of the deadliest diseases in our society. Surgery accompanied by subsequent chemotherapy is the treatment most used to prolong or save the patient’s life. Still, it carries secondary risks such as infections and thrombosis and causes cytotoxic effects in healthy tissues. Using nanocarriers such as smart polymer micelles is a promising alternative to avoid or minimize these problems. These nanostructured systems will be able to encapsulate hydrophilic and hydrophobic drugs through modified copolymers with various functional groups such as carboxyls, amines, hydroxyls, etc. The release of the drug occurs due to the structural degradation of these copolymers when they are subjected to endogenous (pH, redox reactions, and enzymatic activity) and exogenous (temperature, ultrasound, light, magnetic and electric field) stimuli. We did a systematic review of the efficacy of smart polymeric micelles as nanocarriers for anticancer drugs (doxorubicin, paclitaxel, docetaxel, lapatinib, cisplatin, adriamycin, and curcumin). For this reason, we evaluate the influence of the synthesis methods and the physicochemical properties of these systems that subsequently allow an effective encapsulation and release of the drug. On the other hand, we demonstrate how computational chemistry will enable us to guide and optimize the design of these micelles to carry out better experimental work. |
| first_indexed | 2024-03-11T10:07:07Z |
| format | Article |
| id | doaj.art-b0e7cb55bc184c2baf095f7b7896d165 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T10:07:07Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-b0e7cb55bc184c2baf095f7b7896d1652023-11-16T15:00:19ZengMDPI AGCancers2072-66942022-12-01151410.3390/cancers15010004Smart Polymeric Micelles for Anticancer Hydrophobic DrugsAndy Guzmán Rodríguez0Marquiza Sablón Carrazana1Chrislayne Rodríguez Tanty2Martijn J. A. Malessy3Gastón Fuentes4Luis J. Cruz5Translational Nanomedicine and Imaging Group, Department of Radiology, K2-24g room, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The NetherlandsCuban Center of Neurosciences, La Habana 11600, CubaCuban Center of Neurosciences, La Habana 11600, CubaDepartment of Neurosurgery, J-11-R-84 room, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The NetherlandsTranslational Nanomedicine and Imaging Group, Department of Radiology, K2-24g room, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The NetherlandsTranslational Nanomedicine and Imaging Group, Department of Radiology, K2-24g room, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The NetherlandsCancer has become one of the deadliest diseases in our society. Surgery accompanied by subsequent chemotherapy is the treatment most used to prolong or save the patient’s life. Still, it carries secondary risks such as infections and thrombosis and causes cytotoxic effects in healthy tissues. Using nanocarriers such as smart polymer micelles is a promising alternative to avoid or minimize these problems. These nanostructured systems will be able to encapsulate hydrophilic and hydrophobic drugs through modified copolymers with various functional groups such as carboxyls, amines, hydroxyls, etc. The release of the drug occurs due to the structural degradation of these copolymers when they are subjected to endogenous (pH, redox reactions, and enzymatic activity) and exogenous (temperature, ultrasound, light, magnetic and electric field) stimuli. We did a systematic review of the efficacy of smart polymeric micelles as nanocarriers for anticancer drugs (doxorubicin, paclitaxel, docetaxel, lapatinib, cisplatin, adriamycin, and curcumin). For this reason, we evaluate the influence of the synthesis methods and the physicochemical properties of these systems that subsequently allow an effective encapsulation and release of the drug. On the other hand, we demonstrate how computational chemistry will enable us to guide and optimize the design of these micelles to carry out better experimental work.https://www.mdpi.com/2072-6694/15/1/4smart polymeric micellesanticancer hydrophobic drugsnanocarrierssmart drug-delivery systemsgold nanoparticles |
| spellingShingle | Andy Guzmán Rodríguez Marquiza Sablón Carrazana Chrislayne Rodríguez Tanty Martijn J. A. Malessy Gastón Fuentes Luis J. Cruz Smart Polymeric Micelles for Anticancer Hydrophobic Drugs Cancers smart polymeric micelles anticancer hydrophobic drugs nanocarriers smart drug-delivery systems gold nanoparticles |
| title | Smart Polymeric Micelles for Anticancer Hydrophobic Drugs |
| title_full | Smart Polymeric Micelles for Anticancer Hydrophobic Drugs |
| title_fullStr | Smart Polymeric Micelles for Anticancer Hydrophobic Drugs |
| title_full_unstemmed | Smart Polymeric Micelles for Anticancer Hydrophobic Drugs |
| title_short | Smart Polymeric Micelles for Anticancer Hydrophobic Drugs |
| title_sort | smart polymeric micelles for anticancer hydrophobic drugs |
| topic | smart polymeric micelles anticancer hydrophobic drugs nanocarriers smart drug-delivery systems gold nanoparticles |
| url | https://www.mdpi.com/2072-6694/15/1/4 |
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