Roles of Integrin α6β4 Glycosylation in Cancer
Malignant transformation is accompanied with aberrant glycosylation of proteins. Such changes in glycan structure also occur in the integrins, which are a large family of cell surface receptors for the extracellular matrix and play key roles in tumor progression. There is now increasing evidence tha...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-07-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/9/7/79 |
| _version_ | 1797766464690716672 |
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| author | Yoshinobu Kariya Yukiko Kariya Jianguo Gu |
| author_facet | Yoshinobu Kariya Yukiko Kariya Jianguo Gu |
| author_sort | Yoshinobu Kariya |
| collection | DOAJ |
| description | Malignant transformation is accompanied with aberrant glycosylation of proteins. Such changes in glycan structure also occur in the integrins, which are a large family of cell surface receptors for the extracellular matrix and play key roles in tumor progression. There is now increasing evidence that glycosylation of integrins affects cellular signaling and interaction with the extracellular matrix, receptor tyrosine kinases, and galectins, thereby regulating cell adhesion, motility, growth, and survival. Integrin α6β4 is a receptor for laminin-332 and the increased expression level is correlated with malignant progression and poor survival in various types of cancers. Recent studies have revealed that integrin α6β4 plays central roles in tumorigenesis and the metastatic process. In this review, we summarize our current understanding of the molecular mechanisms of tumor progression driven by integrin α6β4 and also discuss the modification of glycans on integrin β4 subunit to address the important roles of glycan in integrin-mediated tumor progression. |
| first_indexed | 2024-03-12T20:25:41Z |
| format | Article |
| id | doaj.art-b0e84c4659f949079a4b7541ccbc5f5c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T20:25:41Z |
| publishDate | 2017-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-b0e84c4659f949079a4b7541ccbc5f5c2023-08-02T00:33:31ZengMDPI AGCancers2072-66942017-07-01977910.3390/cancers9070079cancers9070079Roles of Integrin α6β4 Glycosylation in CancerYoshinobu Kariya0Yukiko Kariya1Jianguo Gu2Department of Biochemistry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima 960-1295, JapanDepartment of Biochemistry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima 960-1295, JapanDivision of Regulatory Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi 981-8558, JapanMalignant transformation is accompanied with aberrant glycosylation of proteins. Such changes in glycan structure also occur in the integrins, which are a large family of cell surface receptors for the extracellular matrix and play key roles in tumor progression. There is now increasing evidence that glycosylation of integrins affects cellular signaling and interaction with the extracellular matrix, receptor tyrosine kinases, and galectins, thereby regulating cell adhesion, motility, growth, and survival. Integrin α6β4 is a receptor for laminin-332 and the increased expression level is correlated with malignant progression and poor survival in various types of cancers. Recent studies have revealed that integrin α6β4 plays central roles in tumorigenesis and the metastatic process. In this review, we summarize our current understanding of the molecular mechanisms of tumor progression driven by integrin α6β4 and also discuss the modification of glycans on integrin β4 subunit to address the important roles of glycan in integrin-mediated tumor progression.https://www.mdpi.com/2072-6694/9/7/79integringlycosylationcancerN-acetylglucosaminyltransferase-V (GnT-V)epithelial to mesenchymal transition (EMT)galectin-3 |
| spellingShingle | Yoshinobu Kariya Yukiko Kariya Jianguo Gu Roles of Integrin α6β4 Glycosylation in Cancer Cancers integrin glycosylation cancer N-acetylglucosaminyltransferase-V (GnT-V) epithelial to mesenchymal transition (EMT) galectin-3 |
| title | Roles of Integrin α6β4 Glycosylation in Cancer |
| title_full | Roles of Integrin α6β4 Glycosylation in Cancer |
| title_fullStr | Roles of Integrin α6β4 Glycosylation in Cancer |
| title_full_unstemmed | Roles of Integrin α6β4 Glycosylation in Cancer |
| title_short | Roles of Integrin α6β4 Glycosylation in Cancer |
| title_sort | roles of integrin α6β4 glycosylation in cancer |
| topic | integrin glycosylation cancer N-acetylglucosaminyltransferase-V (GnT-V) epithelial to mesenchymal transition (EMT) galectin-3 |
| url | https://www.mdpi.com/2072-6694/9/7/79 |
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