Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth
The mammalian target of rapamycin complex 1 (mTORC1) senses multiple upstream stimuli to orchestrate anabolic and catabolic events that regulate cell growth and metabolism. Hyperactivation of mTORC1 signaling is observed in multiple human diseases; thus, pathways that suppress mTORC1 signaling may h...
Main Authors: | Mi-Hyeon Jeong, Greg Urquhart, Cheryl Lewis, Zhikai Chi, Jenna L. Jewell |
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Format: | Article |
Language: | English |
Published: |
American Society for Clinical investigation
2023-07-01
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Series: | JCI Insight |
Subjects: | |
Online Access: | https://doi.org/10.1172/jci.insight.158098 |
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