Correlation between antibiotic consumption and resistance of Pseudomonas aeruginosa in a teaching hospital implementing an antimicrobial stewardship program: A longitudinal observational study
Background/purpose: The rapid emergence of Pseudomonas aeruginosa resistance made selecting antibiotics more challenge. Antimicrobial stewardship programs (ASPs) are urging to implant to control the P. aeruginosa resistance. The purpose of this study is to evaluate the relationship between antimicro...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-04-01
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| Series: | Journal of Microbiology, Immunology and Infection |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1684118222001463 |
| _version_ | 1797869859203186688 |
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| author | Hsiao-Wen Huang Hsin-Yi Liu Han-Chuan Chuang Bi-Li Chen Er-Ying Wang Li-Hsin Tsao Ming-Ying Ai Yuarn-Jang Lee |
| author_facet | Hsiao-Wen Huang Hsin-Yi Liu Han-Chuan Chuang Bi-Li Chen Er-Ying Wang Li-Hsin Tsao Ming-Ying Ai Yuarn-Jang Lee |
| author_sort | Hsiao-Wen Huang |
| collection | DOAJ |
| description | Background/purpose: The rapid emergence of Pseudomonas aeruginosa resistance made selecting antibiotics more challenge. Antimicrobial stewardship programs (ASPs) are urging to implant to control the P. aeruginosa resistance. The purpose of this study is to evaluate the relationship between antimicrobial consumption and P. aeruginosa resistance, the impact of ASPs implemented during the 14-year study period. Methods: A total 14,852 P. aeruginosa isolates were included in our study. The resistant rate and antimicrobial consumption were investigated every six months. Linear regression analysis was conducted to examine the trends in antibiotics consumption and antimicrobial resistance over time. The relationship between P. aeruginosa resistance and antimicrobial consumption were using Pearson correlation coefficient to analysis. The trend of resistance before and after ASPs implanted is evaluated by segment regression analysis. Results: P. aeruginosa resistance to ceftazidime, gentamicin, amikacin, ciprofloxacin and levofloxacin significantly decreased during the study period; piperacillin/tazobactam (PTZ), cefepime, imipenem/cilastatin and meropenem remained stable. The P. aeruginosa resistance to ciprofloxacin and levofloxacin increasing initial then decreased after strictly controlled the use of levofloxacin since 2007. As the first choice antibiotic to treat P. aeruginosa, the consumption and resistance to PTZ increase yearly and resistance became stable since extended-infusion therapy policy implant in 2009. Conclusion: Our ASP intervention strategy, which included extended infusion of PTZ and restrict use of levofloxacin, may be used to control antimicrobial resistance of P. aeruginosa in medical practice. |
| first_indexed | 2024-04-10T00:18:09Z |
| format | Article |
| id | doaj.art-b0eb186ddef945fcb9ef9e46594831ae |
| institution | Directory Open Access Journal |
| issn | 1684-1182 |
| language | English |
| last_indexed | 2024-04-10T00:18:09Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Microbiology, Immunology and Infection |
| spelling | doaj.art-b0eb186ddef945fcb9ef9e46594831ae2023-03-16T05:03:26ZengElsevierJournal of Microbiology, Immunology and Infection1684-11822023-04-01562337343Correlation between antibiotic consumption and resistance of Pseudomonas aeruginosa in a teaching hospital implementing an antimicrobial stewardship program: A longitudinal observational studyHsiao-Wen Huang0Hsin-Yi Liu1Han-Chuan Chuang2Bi-Li Chen3Er-Ying Wang4Li-Hsin Tsao5Ming-Ying Ai6Yuarn-Jang Lee7Department of Internal Medicine, Taipei Medical University Hospital, Taipei, TaiwanDepartment of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan; Division of Infectious Diseases, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan; Department of Infection Control, Taipei Medical University Hospital, Taipei, TaiwanDepartment of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan; Division of Infectious Diseases, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan; Department of Infection Control, Taipei Medical University Hospital, Taipei, TaiwanDepartment of Pharmacy, Taipei Medical University Hospital, Taipei, Taiwan; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, TaiwanDepartment of Pharmacy, Taipei Medical University Hospital, Taipei, Taiwan; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, TaiwanDivision of Infectious Diseases, Department of Internal Medicine, Lienchiang County Hospital, Matsu, TaiwanDepartment of Pharmacy, Taipei Medical University Hospital, Taipei, Taiwan; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan; Department of Pharmacy, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Corresponding author. Department of Pharmacy, Far Eastern Memorial Hospital, No. 21, Section 2, Nanya S. Road, Banqiao District, New Taipei City 220, TaiwanDepartment of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan; Division of Infectious Diseases, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan; Division of Infectious Diseases, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taiwan; Corresponding author. Division of Infectious Diseases, Department of Internal Medicine, Taipei Medical University - Shuang Ho Hospital, Ministry of Health and Welfare, No. 291, Zhongzheng Rd., Zhonghe District, New Taipei City, 23561, Taiwan.Background/purpose: The rapid emergence of Pseudomonas aeruginosa resistance made selecting antibiotics more challenge. Antimicrobial stewardship programs (ASPs) are urging to implant to control the P. aeruginosa resistance. The purpose of this study is to evaluate the relationship between antimicrobial consumption and P. aeruginosa resistance, the impact of ASPs implemented during the 14-year study period. Methods: A total 14,852 P. aeruginosa isolates were included in our study. The resistant rate and antimicrobial consumption were investigated every six months. Linear regression analysis was conducted to examine the trends in antibiotics consumption and antimicrobial resistance over time. The relationship between P. aeruginosa resistance and antimicrobial consumption were using Pearson correlation coefficient to analysis. The trend of resistance before and after ASPs implanted is evaluated by segment regression analysis. Results: P. aeruginosa resistance to ceftazidime, gentamicin, amikacin, ciprofloxacin and levofloxacin significantly decreased during the study period; piperacillin/tazobactam (PTZ), cefepime, imipenem/cilastatin and meropenem remained stable. The P. aeruginosa resistance to ciprofloxacin and levofloxacin increasing initial then decreased after strictly controlled the use of levofloxacin since 2007. As the first choice antibiotic to treat P. aeruginosa, the consumption and resistance to PTZ increase yearly and resistance became stable since extended-infusion therapy policy implant in 2009. Conclusion: Our ASP intervention strategy, which included extended infusion of PTZ and restrict use of levofloxacin, may be used to control antimicrobial resistance of P. aeruginosa in medical practice.http://www.sciencedirect.com/science/article/pii/S1684118222001463Antimicrobial stewardship programs (ASPs)Pseudomonas aeruginosa (P. aeruginosa)ResistanceAntibiotics consumptionExtended-infusion therapy |
| spellingShingle | Hsiao-Wen Huang Hsin-Yi Liu Han-Chuan Chuang Bi-Li Chen Er-Ying Wang Li-Hsin Tsao Ming-Ying Ai Yuarn-Jang Lee Correlation between antibiotic consumption and resistance of Pseudomonas aeruginosa in a teaching hospital implementing an antimicrobial stewardship program: A longitudinal observational study Journal of Microbiology, Immunology and Infection Antimicrobial stewardship programs (ASPs) Pseudomonas aeruginosa (P. aeruginosa) Resistance Antibiotics consumption Extended-infusion therapy |
| title | Correlation between antibiotic consumption and resistance of Pseudomonas aeruginosa in a teaching hospital implementing an antimicrobial stewardship program: A longitudinal observational study |
| title_full | Correlation between antibiotic consumption and resistance of Pseudomonas aeruginosa in a teaching hospital implementing an antimicrobial stewardship program: A longitudinal observational study |
| title_fullStr | Correlation between antibiotic consumption and resistance of Pseudomonas aeruginosa in a teaching hospital implementing an antimicrobial stewardship program: A longitudinal observational study |
| title_full_unstemmed | Correlation between antibiotic consumption and resistance of Pseudomonas aeruginosa in a teaching hospital implementing an antimicrobial stewardship program: A longitudinal observational study |
| title_short | Correlation between antibiotic consumption and resistance of Pseudomonas aeruginosa in a teaching hospital implementing an antimicrobial stewardship program: A longitudinal observational study |
| title_sort | correlation between antibiotic consumption and resistance of pseudomonas aeruginosa in a teaching hospital implementing an antimicrobial stewardship program a longitudinal observational study |
| topic | Antimicrobial stewardship programs (ASPs) Pseudomonas aeruginosa (P. aeruginosa) Resistance Antibiotics consumption Extended-infusion therapy |
| url | http://www.sciencedirect.com/science/article/pii/S1684118222001463 |
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