Immediate hypersensitivity reaction followed by successful oral desensitization to ursodiol
Abstract Background Immediate hypersensitivity reaction to ursodiol is rare and there is no previously published protocol on ursodiol desensitization. Case presentation A 59-year-old woman with primary biliary cholangitis (PBC) developed an immediate hypersensitivity reaction to ursodiol—the first-l...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2021-07-01
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| Series: | Allergy, Asthma & Clinical Immunology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13223-021-00578-7 |
| _version_ | 1818455127038623744 |
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| author | Erika Yue Lee Christine Song |
| author_facet | Erika Yue Lee Christine Song |
| author_sort | Erika Yue Lee |
| collection | DOAJ |
| description | Abstract Background Immediate hypersensitivity reaction to ursodiol is rare and there is no previously published protocol on ursodiol desensitization. Case presentation A 59-year-old woman with primary biliary cholangitis (PBC) developed an immediate hypersensitivity reaction to ursodiol—the first-line treatment for PBC. When she switched to a second-line treatment, her PBC continued to progress. As such, she completed a novel 12-step desensitization protocol to oral ursodiol. She experienced recurrent pruritus after each dose following desensitization, which subsided after a month of being on daily ursodiol. Conclusion Immediate hypersensitivity reaction to ursodiol is uncommon. Our case demonstrated that this novel desensitization protocol to ursodiol could be safely implemented when alternative options are not available or have proven inferior in efficacy. |
| first_indexed | 2024-12-14T22:05:50Z |
| format | Article |
| id | doaj.art-b0eb5cd4e7614531935704cf6a16595f |
| institution | Directory Open Access Journal |
| issn | 1710-1492 |
| language | English |
| last_indexed | 2024-12-14T22:05:50Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Allergy, Asthma & Clinical Immunology |
| spelling | doaj.art-b0eb5cd4e7614531935704cf6a16595f2022-12-21T22:45:52ZengBMCAllergy, Asthma & Clinical Immunology1710-14922021-07-011711310.1186/s13223-021-00578-7Immediate hypersensitivity reaction followed by successful oral desensitization to ursodiolErika Yue Lee0Christine Song1Department of Medicine, University of TorontoDepartment of Medicine, University of TorontoAbstract Background Immediate hypersensitivity reaction to ursodiol is rare and there is no previously published protocol on ursodiol desensitization. Case presentation A 59-year-old woman with primary biliary cholangitis (PBC) developed an immediate hypersensitivity reaction to ursodiol—the first-line treatment for PBC. When she switched to a second-line treatment, her PBC continued to progress. As such, she completed a novel 12-step desensitization protocol to oral ursodiol. She experienced recurrent pruritus after each dose following desensitization, which subsided after a month of being on daily ursodiol. Conclusion Immediate hypersensitivity reaction to ursodiol is uncommon. Our case demonstrated that this novel desensitization protocol to ursodiol could be safely implemented when alternative options are not available or have proven inferior in efficacy.https://doi.org/10.1186/s13223-021-00578-7Immediate drug hypersensitivityUrsodiolUrsodeoxycholic acidDesensitizationPrimary biliary cholangitis |
| spellingShingle | Erika Yue Lee Christine Song Immediate hypersensitivity reaction followed by successful oral desensitization to ursodiol Allergy, Asthma & Clinical Immunology Immediate drug hypersensitivity Ursodiol Ursodeoxycholic acid Desensitization Primary biliary cholangitis |
| title | Immediate hypersensitivity reaction followed by successful oral desensitization to ursodiol |
| title_full | Immediate hypersensitivity reaction followed by successful oral desensitization to ursodiol |
| title_fullStr | Immediate hypersensitivity reaction followed by successful oral desensitization to ursodiol |
| title_full_unstemmed | Immediate hypersensitivity reaction followed by successful oral desensitization to ursodiol |
| title_short | Immediate hypersensitivity reaction followed by successful oral desensitization to ursodiol |
| title_sort | immediate hypersensitivity reaction followed by successful oral desensitization to ursodiol |
| topic | Immediate drug hypersensitivity Ursodiol Ursodeoxycholic acid Desensitization Primary biliary cholangitis |
| url | https://doi.org/10.1186/s13223-021-00578-7 |
| work_keys_str_mv | AT erikayuelee immediatehypersensitivityreactionfollowedbysuccessfuloraldesensitizationtoursodiol AT christinesong immediatehypersensitivityreactionfollowedbysuccessfuloraldesensitizationtoursodiol |