Current and Future Approaches for Monitoring Responses to Anti-complement Therapeutics
Aberrations in complement system functions have been identified as either direct or indirect pathophysiological mechanisms in many diseases and pathological conditions, such as infections, autoimmune diseases, inflammation, malignancies, and allogeneic transplantation. Currently available techniques...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.02539/full |
| _version_ | 1819237863860994048 |
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| author | Maedeh Mohebnasab Oskar Eriksson Barbro Persson Kerstin Sandholm Camilla Mohlin Markus Huber-Lang Brendan J. Keating Kristina N. Ekdahl Kristina N. Ekdahl Bo Nilsson |
| author_facet | Maedeh Mohebnasab Oskar Eriksson Barbro Persson Kerstin Sandholm Camilla Mohlin Markus Huber-Lang Brendan J. Keating Kristina N. Ekdahl Kristina N. Ekdahl Bo Nilsson |
| author_sort | Maedeh Mohebnasab |
| collection | DOAJ |
| description | Aberrations in complement system functions have been identified as either direct or indirect pathophysiological mechanisms in many diseases and pathological conditions, such as infections, autoimmune diseases, inflammation, malignancies, and allogeneic transplantation. Currently available techniques to study complement include quantification of (a) individual complement components, (b) complement activation products, and (c) molecular mechanisms/function. An emerging area of major interest in translational studies aims to study and monitor patients on complement regulatory drugs for efficacy as well as adverse events. This area is progressing rapidly with several anti-complement therapeutics under development, in clinical trials, or already in clinical use. In this review, we summarized the appropriate indications, techniques, and interpretations of basic complement analyses, exemplified by a number of clinical disorders. |
| first_indexed | 2024-12-23T13:27:06Z |
| format | Article |
| id | doaj.art-b0ed3d07d90643b597d2cead0f442c2f |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-23T13:27:06Z |
| publishDate | 2019-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b0ed3d07d90643b597d2cead0f442c2f2022-12-21T17:45:16ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-11-011010.3389/fimmu.2019.02539468455Current and Future Approaches for Monitoring Responses to Anti-complement TherapeuticsMaedeh Mohebnasab0Oskar Eriksson1Barbro Persson2Kerstin Sandholm3Camilla Mohlin4Markus Huber-Lang5Brendan J. Keating6Kristina N. Ekdahl7Kristina N. Ekdahl8Bo Nilsson9Division of Transplantation, Department of Surgery, University of Pennsylvania, Philadelphia, PA, United StatesRudbeck Laboratory C5:3, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, SwedenRudbeck Laboratory C5:3, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, SwedenCentre of Biomaterials Chemistry, Linnaeus University, Kalmar, SwedenCentre of Biomaterials Chemistry, Linnaeus University, Kalmar, SwedenInstitute for Clinical and Experimental Trauma Immunology, University Hospital of Ulm, Ulm, GermanyDivision of Transplantation, Department of Surgery, University of Pennsylvania, Philadelphia, PA, United StatesRudbeck Laboratory C5:3, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, SwedenCentre of Biomaterials Chemistry, Linnaeus University, Kalmar, SwedenRudbeck Laboratory C5:3, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, SwedenAberrations in complement system functions have been identified as either direct or indirect pathophysiological mechanisms in many diseases and pathological conditions, such as infections, autoimmune diseases, inflammation, malignancies, and allogeneic transplantation. Currently available techniques to study complement include quantification of (a) individual complement components, (b) complement activation products, and (c) molecular mechanisms/function. An emerging area of major interest in translational studies aims to study and monitor patients on complement regulatory drugs for efficacy as well as adverse events. This area is progressing rapidly with several anti-complement therapeutics under development, in clinical trials, or already in clinical use. In this review, we summarized the appropriate indications, techniques, and interpretations of basic complement analyses, exemplified by a number of clinical disorders.https://www.frontiersin.org/article/10.3389/fimmu.2019.02539/fullclinical triallaboratory investigationimmunoassaysfunctional assaysCV% |
| spellingShingle | Maedeh Mohebnasab Oskar Eriksson Barbro Persson Kerstin Sandholm Camilla Mohlin Markus Huber-Lang Brendan J. Keating Kristina N. Ekdahl Kristina N. Ekdahl Bo Nilsson Current and Future Approaches for Monitoring Responses to Anti-complement Therapeutics Frontiers in Immunology clinical trial laboratory investigation immunoassays functional assays CV% |
| title | Current and Future Approaches for Monitoring Responses to Anti-complement Therapeutics |
| title_full | Current and Future Approaches for Monitoring Responses to Anti-complement Therapeutics |
| title_fullStr | Current and Future Approaches for Monitoring Responses to Anti-complement Therapeutics |
| title_full_unstemmed | Current and Future Approaches for Monitoring Responses to Anti-complement Therapeutics |
| title_short | Current and Future Approaches for Monitoring Responses to Anti-complement Therapeutics |
| title_sort | current and future approaches for monitoring responses to anti complement therapeutics |
| topic | clinical trial laboratory investigation immunoassays functional assays CV% |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.02539/full |
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