From research to practice: clinical phases for drug development
Clinical trials become very relevant in the development of new drugs when their pharmacokinetics, pharmacodynamics, efficiency, safety and possible adverse effects are being assessed. So new drugs are available for their daily use in patients, a model has been proposed for more than four decades; Th...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Colegio Mexicano de Inmunología Clínica y Alergia, A.C.
2019-06-01
|
| Series: | Revista Alergia México |
| Subjects: | |
| Online Access: | http://revistaalergia.mx/ojs/index.php/ram/article/view/625 |
| _version_ | 1797714039737942016 |
|---|---|
| author | Jessie Nallely Zurita-Cruz Lourdes Barbosa-Cortés Miguel Ángel Villasís-Keever |
| author_facet | Jessie Nallely Zurita-Cruz Lourdes Barbosa-Cortés Miguel Ángel Villasís-Keever |
| author_sort | Jessie Nallely Zurita-Cruz |
| collection | DOAJ |
| description | Clinical trials become very relevant in the development of new drugs when their pharmacokinetics, pharmacodynamics, efficiency, safety and possible adverse effects are being assessed. So new drugs are available for their daily use in patients, a model has been proposed for more than four decades; This model consists in the realization of sequential research studies, which were called clinical phases I, II, III and IV, which begin once the drugs’ effects have been verified in cellular and animal models (preclinical phase). In this article, the general characteristics of each of the clinical phases are synthesized but, apart from that, the modifications that have been done over the years are described with the purpose of making new drugs available in a quicker way. |
| first_indexed | 2024-03-12T07:47:08Z |
| format | Article |
| id | doaj.art-b0ed7832895d4fafbb3d81be64f96051 |
| institution | Directory Open Access Journal |
| issn | 0002-5151 2448-9190 |
| language | English |
| last_indexed | 2024-03-12T07:47:08Z |
| publishDate | 2019-06-01 |
| publisher | Colegio Mexicano de Inmunología Clínica y Alergia, A.C. |
| record_format | Article |
| series | Revista Alergia México |
| spelling | doaj.art-b0ed7832895d4fafbb3d81be64f960512023-09-02T20:57:39ZengColegio Mexicano de Inmunología Clínica y Alergia, A.C.Revista Alergia México0002-51512448-91902019-06-0166224625310.29262/ram.v66i2.625419From research to practice: clinical phases for drug developmentJessie Nallely Zurita-Cruz0Lourdes Barbosa-Cortés1Miguel Ángel Villasís-Keever2Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Pediatría, Ciudad de MéxicoInstituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Pediatría, Ciudad de MéxicoInstituto Mexicano del Seguro Social, Coordinación de Investigación en Salud, Unidad de Investigación en Análisis y Síntesis de la Evidencia, Ciudad de MéxicoClinical trials become very relevant in the development of new drugs when their pharmacokinetics, pharmacodynamics, efficiency, safety and possible adverse effects are being assessed. So new drugs are available for their daily use in patients, a model has been proposed for more than four decades; This model consists in the realization of sequential research studies, which were called clinical phases I, II, III and IV, which begin once the drugs’ effects have been verified in cellular and animal models (preclinical phase). In this article, the general characteristics of each of the clinical phases are synthesized but, apart from that, the modifications that have been done over the years are described with the purpose of making new drugs available in a quicker way.http://revistaalergia.mx/ojs/index.php/ram/article/view/625investigación clínicaensayos clínicosdiseño de fármacos |
| spellingShingle | Jessie Nallely Zurita-Cruz Lourdes Barbosa-Cortés Miguel Ángel Villasís-Keever From research to practice: clinical phases for drug development Revista Alergia México investigación clínica ensayos clínicos diseño de fármacos |
| title | From research to practice: clinical phases for drug development |
| title_full | From research to practice: clinical phases for drug development |
| title_fullStr | From research to practice: clinical phases for drug development |
| title_full_unstemmed | From research to practice: clinical phases for drug development |
| title_short | From research to practice: clinical phases for drug development |
| title_sort | from research to practice clinical phases for drug development |
| topic | investigación clínica ensayos clínicos diseño de fármacos |
| url | http://revistaalergia.mx/ojs/index.php/ram/article/view/625 |
| work_keys_str_mv | AT jessienallelyzuritacruz fromresearchtopracticeclinicalphasesfordrugdevelopment AT lourdesbarbosacortes fromresearchtopracticeclinicalphasesfordrugdevelopment AT miguelangelvillasiskeever fromresearchtopracticeclinicalphasesfordrugdevelopment |