Prevalence rate of resistance to ciprofloxacin among clinical Pseudomonas Aeruginosa isolates in Kurdistanprovince, west of Iran
Background and Aim:Infection by drug resistant Pseudomonas aeruginosacauses important therapeutic problems. The present study was performed to investigate the antibiotic susceptibility and prevalence of antimicrobial resistance genes in P. aeruginosa.Materials and Methods:In this cross section...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | fas |
| Published: |
Kurdistan University of Medical Sciences
2020-01-01
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| Series: | مجله علمی دانشگاه علوم پزشکی کردستان |
| Subjects: | |
| Online Access: | http://sjku.muk.ac.ir/article-1-5063-en.pdf |
| Summary: | Background and Aim:Infection by drug resistant Pseudomonas aeruginosacauses important therapeutic problems. The present study was performed to investigate the antibiotic susceptibility and prevalence of antimicrobial resistance genes in P. aeruginosa.Materials and Methods:In this cross sectional study, 61 clinical P. aeruginosa isolateswere collected in Sanandaj between April and September 2017. Isolates were examined by disk diffusion method to determine susceptibility to 8 antibiotics and by polymerase chain reaction to detect the presence of extended-spectrum beta lactamase blaCTX-M gene and plasmid-mediated quinolone resistance determinants, qnrA, qnrB, and qnrS. We also evaluated the effect of resistance to quinolones on cross resistance to other antibiotics. We used descriptive statistics for data analysis.Results:Meropenem showed the highest susceptibility rate (88.5%), followed by piperacillin (85.2%), ceftazidime and amikacin (80.3%, each), imipenem (77%), cefepime (73.8%), ciprofloxacin (49.2%), and gentamicin (39.3%). Among 61 isolates, 32.8% showed multidrug resistance. Ciprofloxacin-resistant isolates had cross resistance to gentamicin (93.5%), cefepime (45.2%), ceftazidime and imipenem (38.7%, each), amikacin (35.5%), piperacillin (29%), and meropenem (22.6%). We detected qnrS in three isolates (4.9%).blaCTX-M, qnrBand qnrA were not identified. Conclusion:Our results suggested that ciprofloxacinmay not be effective against P. aeruginosa. According to our knowledge, this is the first report of presence of qnr inP. aeruginosa from Kurdistan which highlights the need for continuous monitoring for prevention of the transmission of qnr. |
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| ISSN: | 1560-652X 2345-4040 |