Uveitis and nail psoriasis in a patient without articular involvement: a case report
Abstract Background This study aimed to report a case of bilateral anterior non-granulomatous chronic non-infectious uveitis associated with isolated nail psoriasis without articular involvement. Case presentation A 55-year-old man with a history of open-angle glaucoma was referred to our uveitis an...
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-022-02596-4 |
| _version_ | 1798001687815782400 |
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| author | Juan Sebastián Pineda-Sierra Luisa Fernanda Peña-Pulgar Carlos Cifuentes-González William Rojas-Carabali Alejandra de-la-Torre |
| author_facet | Juan Sebastián Pineda-Sierra Luisa Fernanda Peña-Pulgar Carlos Cifuentes-González William Rojas-Carabali Alejandra de-la-Torre |
| author_sort | Juan Sebastián Pineda-Sierra |
| collection | DOAJ |
| description | Abstract Background This study aimed to report a case of bilateral anterior non-granulomatous chronic non-infectious uveitis associated with isolated nail psoriasis without articular involvement. Case presentation A 55-year-old man with a history of open-angle glaucoma was referred to our uveitis and ocular immunology center with intraocular inflammation concordant with chronic non-infectious bilateral anterior non-granulomatous uveitis. At presentation, he had moderate inflammation in the anterior chamber bilaterally and lesions characteristic of nail psoriasis. Nail psoriasis was later confirmed by nail ultrasonography performed by a radiologist who specialized in psoriasis. Appropriate clinical and paraclinical assessments were conducted, ruling out all other possible causes of uveitis. The patient required dual systemic immunomodulatory therapy with methotrexate and adalimumab, topical anti-inflammatory drugs (steroidal and non-steroidal), and anti-glaucoma therapy to achieve satisfactory inflammatory and ocular pressure control. Discussion and conclusions This is the first report of non-infectious uveitis associated with nail compromise in a patient without other manifestations of psoriasis. Despite reports on the relationship between psoriatic disease and uveitis, there is insufficient information on clinical phenotypes associated with uveitis that could lead to later diagnosis and treatment of associated intraocular inflammation. Clinicians should be aware of all subtypes of psoriasis that increases a risk of developing uveitis in these patients. |
| first_indexed | 2024-04-11T11:40:19Z |
| format | Article |
| id | doaj.art-b0eee338e3444ac7b5bb236c037e396c |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-04-11T11:40:19Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-b0eee338e3444ac7b5bb236c037e396c2022-12-22T04:25:51ZengBMCBMC Ophthalmology1471-24152022-09-012211510.1186/s12886-022-02596-4Uveitis and nail psoriasis in a patient without articular involvement: a case reportJuan Sebastián Pineda-Sierra0Luisa Fernanda Peña-Pulgar1Carlos Cifuentes-González2William Rojas-Carabali3Alejandra de-la-Torre4Neuroscience Research Group (NEUROS), Neurovitae Research Center, Escuela de Medicina Y Ciencias de La Salud, Universidad del RosarioNeuroscience Research Group (NEUROS), Neurovitae Research Center, Escuela de Medicina Y Ciencias de La Salud, Universidad del RosarioNeuroscience Research Group (NEUROS), Neurovitae Research Center, Escuela de Medicina Y Ciencias de La Salud, Universidad del RosarioNeuroscience Research Group (NEUROS), Neurovitae Research Center, Escuela de Medicina Y Ciencias de La Salud, Universidad del RosarioNeuroscience Research Group (NEUROS), Neurovitae Research Center, Escuela de Medicina Y Ciencias de La Salud, Universidad del RosarioAbstract Background This study aimed to report a case of bilateral anterior non-granulomatous chronic non-infectious uveitis associated with isolated nail psoriasis without articular involvement. Case presentation A 55-year-old man with a history of open-angle glaucoma was referred to our uveitis and ocular immunology center with intraocular inflammation concordant with chronic non-infectious bilateral anterior non-granulomatous uveitis. At presentation, he had moderate inflammation in the anterior chamber bilaterally and lesions characteristic of nail psoriasis. Nail psoriasis was later confirmed by nail ultrasonography performed by a radiologist who specialized in psoriasis. Appropriate clinical and paraclinical assessments were conducted, ruling out all other possible causes of uveitis. The patient required dual systemic immunomodulatory therapy with methotrexate and adalimumab, topical anti-inflammatory drugs (steroidal and non-steroidal), and anti-glaucoma therapy to achieve satisfactory inflammatory and ocular pressure control. Discussion and conclusions This is the first report of non-infectious uveitis associated with nail compromise in a patient without other manifestations of psoriasis. Despite reports on the relationship between psoriatic disease and uveitis, there is insufficient information on clinical phenotypes associated with uveitis that could lead to later diagnosis and treatment of associated intraocular inflammation. Clinicians should be aware of all subtypes of psoriasis that increases a risk of developing uveitis in these patients.https://doi.org/10.1186/s12886-022-02596-4PsoriasisNail PsoriasisUveitisAnterior uveitisCase report |
| spellingShingle | Juan Sebastián Pineda-Sierra Luisa Fernanda Peña-Pulgar Carlos Cifuentes-González William Rojas-Carabali Alejandra de-la-Torre Uveitis and nail psoriasis in a patient without articular involvement: a case report BMC Ophthalmology Psoriasis Nail Psoriasis Uveitis Anterior uveitis Case report |
| title | Uveitis and nail psoriasis in a patient without articular involvement: a case report |
| title_full | Uveitis and nail psoriasis in a patient without articular involvement: a case report |
| title_fullStr | Uveitis and nail psoriasis in a patient without articular involvement: a case report |
| title_full_unstemmed | Uveitis and nail psoriasis in a patient without articular involvement: a case report |
| title_short | Uveitis and nail psoriasis in a patient without articular involvement: a case report |
| title_sort | uveitis and nail psoriasis in a patient without articular involvement a case report |
| topic | Psoriasis Nail Psoriasis Uveitis Anterior uveitis Case report |
| url | https://doi.org/10.1186/s12886-022-02596-4 |
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