Effectiveness of combined antihypertensive treatment depending on the phenomenon of salt sensitivity in patients with refractory arterial hypertension
Purpose of study - evaluate the effectiveness of combined antihypertensive treatmentthat includes direct renin inhibitor in salt-sensitive and salt-resistant patients with refractory hypertension (RHT).Methods and materials. The study included 192 patients with RHT. Based on the results of the V.I.K...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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IP Morozov P.V.
2015-12-01
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| Series: | Системные гипертензии |
| Subjects: | |
| Online Access: | https://syst-hypertension.ru/2075-082X/article/viewFile/29111/pdf |
| _version_ | 1818152258347466752 |
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| author | V V Skibitskiy E S Garkusha A V Fendrikova |
| author_facet | V V Skibitskiy E S Garkusha A V Fendrikova |
| author_sort | V V Skibitskiy |
| collection | DOAJ |
| description | Purpose of study - evaluate the effectiveness of combined antihypertensive treatmentthat includes direct renin inhibitor in salt-sensitive and salt-resistant patients with refractory hypertension (RHT).Methods and materials. The study included 192 patients with RHT. Based on the results of the V.I.Kharchenko test and a variation of combined antihypertensive therapy, all patients were randomized into groups: group 1 - salt-sensitive patients treated with an ACE inhibitor (ACEI), dihydropyridine calcium antagonist (CA), thiazide diuretic (TD) and direct renin inhibitor aliskiren (subgroup 1A) or b-blocker - BB (subgroup 1B); group 2 - salt-resistant patients treated with ACE inhibitors, dihydropyridine CA, TD and aliskiren (subgroup 2A) or BB (subgroup 2B). In the absence of achieving target BP after 6 weeks from the start of observation, patients started receiving five-component treatment: ACE inhibitor, CA, TD, BB and aliskiren. Initially and after 48 weeks of observation, all patients underwent ambulatory blood pressure monitoring (ABPM).Results. In the group of salt-sensitive patients treatment including aliskiren contributed to achievement of target values of BP in 43.3%, and with pre- scription of BB - in 54.3% of patients. In both groups there was a significant improvement in most of the parameters of ABPM, more pronounced when using BB. Normalization of circadian BP profile was registered significantly more often ( p |
| first_indexed | 2024-12-11T13:51:52Z |
| format | Article |
| id | doaj.art-b0f3a4a9230641ee83f460223ba2d526 |
| institution | Directory Open Access Journal |
| issn | 2075-082X 2542-2189 |
| language | Russian |
| last_indexed | 2024-12-11T13:51:52Z |
| publishDate | 2015-12-01 |
| publisher | IP Morozov P.V. |
| record_format | Article |
| series | Системные гипертензии |
| spelling | doaj.art-b0f3a4a9230641ee83f460223ba2d5262022-12-22T01:04:14ZrusIP Morozov P.V.Системные гипертензии2075-082X2542-21892015-12-01124303726212Effectiveness of combined antihypertensive treatment depending on the phenomenon of salt sensitivity in patients with refractory arterial hypertensionV V Skibitskiy0E S Garkusha1A V Fendrikova2Kuban State Medical University of the Ministry of Health of the Russian FederationKuban State Medical University of the Ministry of Health of the Russian FederationKuban State Medical University of the Ministry of Health of the Russian FederationPurpose of study - evaluate the effectiveness of combined antihypertensive treatmentthat includes direct renin inhibitor in salt-sensitive and salt-resistant patients with refractory hypertension (RHT).Methods and materials. The study included 192 patients with RHT. Based on the results of the V.I.Kharchenko test and a variation of combined antihypertensive therapy, all patients were randomized into groups: group 1 - salt-sensitive patients treated with an ACE inhibitor (ACEI), dihydropyridine calcium antagonist (CA), thiazide diuretic (TD) and direct renin inhibitor aliskiren (subgroup 1A) or b-blocker - BB (subgroup 1B); group 2 - salt-resistant patients treated with ACE inhibitors, dihydropyridine CA, TD and aliskiren (subgroup 2A) or BB (subgroup 2B). In the absence of achieving target BP after 6 weeks from the start of observation, patients started receiving five-component treatment: ACE inhibitor, CA, TD, BB and aliskiren. Initially and after 48 weeks of observation, all patients underwent ambulatory blood pressure monitoring (ABPM).Results. In the group of salt-sensitive patients treatment including aliskiren contributed to achievement of target values of BP in 43.3%, and with pre- scription of BB - in 54.3% of patients. In both groups there was a significant improvement in most of the parameters of ABPM, more pronounced when using BB. Normalization of circadian BP profile was registered significantly more often ( phttps://syst-hypertension.ru/2075-082X/article/viewFile/29111/pdfrefractory hypertensionsalt sensitivitysalt resistancedirect renin inhibitor |
| spellingShingle | V V Skibitskiy E S Garkusha A V Fendrikova Effectiveness of combined antihypertensive treatment depending on the phenomenon of salt sensitivity in patients with refractory arterial hypertension Системные гипертензии refractory hypertension salt sensitivity salt resistance direct renin inhibitor |
| title | Effectiveness of combined antihypertensive treatment depending on the phenomenon of salt sensitivity in patients with refractory arterial hypertension |
| title_full | Effectiveness of combined antihypertensive treatment depending on the phenomenon of salt sensitivity in patients with refractory arterial hypertension |
| title_fullStr | Effectiveness of combined antihypertensive treatment depending on the phenomenon of salt sensitivity in patients with refractory arterial hypertension |
| title_full_unstemmed | Effectiveness of combined antihypertensive treatment depending on the phenomenon of salt sensitivity in patients with refractory arterial hypertension |
| title_short | Effectiveness of combined antihypertensive treatment depending on the phenomenon of salt sensitivity in patients with refractory arterial hypertension |
| title_sort | effectiveness of combined antihypertensive treatment depending on the phenomenon of salt sensitivity in patients with refractory arterial hypertension |
| topic | refractory hypertension salt sensitivity salt resistance direct renin inhibitor |
| url | https://syst-hypertension.ru/2075-082X/article/viewFile/29111/pdf |
| work_keys_str_mv | AT vvskibitskiy effectivenessofcombinedantihypertensivetreatmentdependingonthephenomenonofsaltsensitivityinpatientswithrefractoryarterialhypertension AT esgarkusha effectivenessofcombinedantihypertensivetreatmentdependingonthephenomenonofsaltsensitivityinpatientswithrefractoryarterialhypertension AT avfendrikova effectivenessofcombinedantihypertensivetreatmentdependingonthephenomenonofsaltsensitivityinpatientswithrefractoryarterialhypertension |