Altered sensorimotor processing in irritable bowel syndrome: Evidence for a transdiagnostic pathomechanism in functional somatic disorders
ObjectiveA recent hypothesis suggests that functional somatic symptoms are due to altered information processing in the brain, with rigid expectations biasing sensorimotor signal processing. First experimental results confirmed such altered processing within the affected symptom modality, e.g., defi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.1029126/full |
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| author | Lena Schröder Lena Schröder Lena Schröder Franziska Regnath Franziska Regnath Stefan Glasauer Stefan Glasauer Anna Hackenberg Juliane Hente Sonja Weilenmann Daniel Pohl Roland von Känel Nadine Lehnen Nadine Lehnen |
| author_facet | Lena Schröder Lena Schröder Lena Schröder Franziska Regnath Franziska Regnath Stefan Glasauer Stefan Glasauer Anna Hackenberg Juliane Hente Sonja Weilenmann Daniel Pohl Roland von Känel Nadine Lehnen Nadine Lehnen |
| author_sort | Lena Schröder |
| collection | DOAJ |
| description | ObjectiveA recent hypothesis suggests that functional somatic symptoms are due to altered information processing in the brain, with rigid expectations biasing sensorimotor signal processing. First experimental results confirmed such altered processing within the affected symptom modality, e.g., deficient eye-head coordination in patients with functional dizziness. Studies in patients with functional somatic symptoms looking at general, trans-symptomatic processing deficits are sparse. Here, we investigate sensorimotor processing during eye-head gaze shifts in irritable bowel syndrome (IBS) to test whether processing deficits exist across symptom modalities.MethodsStudy participants were seven patients suffering from IBS and seven age- and gender-matched healthy controls who performed large gaze shifts toward visual targets. Participants performed combined eye-head gaze shifts in the natural condition and with experimentally increased head moment of inertia. Head oscillations as a marker for sensorimotor processing deficits were assessed. Bayes statistics was used to assess evidence for the presence or absence of processing differences between IBS patients and healthy controls.ResultsWith the head moment of inertia increased, IBS patients displayed more pronounced head oscillations than healthy controls (Bayes Factor 10 = 56.4, corresponding to strong evidence).ConclusionPatients with IBS show sensorimotor processing deficits, reflected by increased head oscillations during large gaze shifts to visual targets. In particular, patients with IBS have difficulties to adapt to the context of altered head moment of inertia. Our results suggest general transdiagnostic processing deficits in functional somatic disorders. |
| first_indexed | 2024-04-11T07:09:12Z |
| format | Article |
| id | doaj.art-b0f4d90fa71445ce99a6cc8847130173 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-11T07:09:12Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-b0f4d90fa71445ce99a6cc88471301732022-12-22T04:38:15ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-11-011610.3389/fnins.2022.10291261029126Altered sensorimotor processing in irritable bowel syndrome: Evidence for a transdiagnostic pathomechanism in functional somatic disordersLena Schröder0Lena Schröder1Lena Schröder2Franziska Regnath3Franziska Regnath4Stefan Glasauer5Stefan Glasauer6Anna Hackenberg7Juliane Hente8Sonja Weilenmann9Daniel Pohl10Roland von Känel11Nadine Lehnen12Nadine Lehnen13Department of Psychosomatic Medicine and Psychotherapy, Klinikum rechts der Isar of the Technical University of Munich, Munich, GermanyComputational Neuroscience, Institute of Medical Technology, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg, GermanyGraduate School of Systemic Neurosciences, Ludwig-Maximilians-Universität München, Planegg, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, Klinikum rechts der Isar of the Technical University of Munich, Munich, GermanyDepartment of Sport and Health Sciences, TUM Graduate School, Technical University of Munich, Munich, GermanyComputational Neuroscience, Institute of Medical Technology, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg, GermanyFaculty of Health Sciences Brandenburg, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, Klinikum rechts der Isar of the Technical University of Munich, Munich, GermanyDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, SwitzerlandDepartment of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Zurich, SwitzerlandDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, SwitzerlandDepartment of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Zurich, SwitzerlandDepartment of Psychosomatic Medicine and Psychotherapy, Klinikum rechts der Isar of the Technical University of Munich, Munich, GermanyInsititute of Medical Technology, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg, GermanyObjectiveA recent hypothesis suggests that functional somatic symptoms are due to altered information processing in the brain, with rigid expectations biasing sensorimotor signal processing. First experimental results confirmed such altered processing within the affected symptom modality, e.g., deficient eye-head coordination in patients with functional dizziness. Studies in patients with functional somatic symptoms looking at general, trans-symptomatic processing deficits are sparse. Here, we investigate sensorimotor processing during eye-head gaze shifts in irritable bowel syndrome (IBS) to test whether processing deficits exist across symptom modalities.MethodsStudy participants were seven patients suffering from IBS and seven age- and gender-matched healthy controls who performed large gaze shifts toward visual targets. Participants performed combined eye-head gaze shifts in the natural condition and with experimentally increased head moment of inertia. Head oscillations as a marker for sensorimotor processing deficits were assessed. Bayes statistics was used to assess evidence for the presence or absence of processing differences between IBS patients and healthy controls.ResultsWith the head moment of inertia increased, IBS patients displayed more pronounced head oscillations than healthy controls (Bayes Factor 10 = 56.4, corresponding to strong evidence).ConclusionPatients with IBS show sensorimotor processing deficits, reflected by increased head oscillations during large gaze shifts to visual targets. In particular, patients with IBS have difficulties to adapt to the context of altered head moment of inertia. Our results suggest general transdiagnostic processing deficits in functional somatic disorders.https://www.frontiersin.org/articles/10.3389/fnins.2022.1029126/fullirritable bowel syndrome (IBS)functional somatic disorderssomatoform disorderspredictive processingtransdiagnostic mechanismgaze shift |
| spellingShingle | Lena Schröder Lena Schröder Lena Schröder Franziska Regnath Franziska Regnath Stefan Glasauer Stefan Glasauer Anna Hackenberg Juliane Hente Sonja Weilenmann Daniel Pohl Roland von Känel Nadine Lehnen Nadine Lehnen Altered sensorimotor processing in irritable bowel syndrome: Evidence for a transdiagnostic pathomechanism in functional somatic disorders Frontiers in Neuroscience irritable bowel syndrome (IBS) functional somatic disorders somatoform disorders predictive processing transdiagnostic mechanism gaze shift |
| title | Altered sensorimotor processing in irritable bowel syndrome: Evidence for a transdiagnostic pathomechanism in functional somatic disorders |
| title_full | Altered sensorimotor processing in irritable bowel syndrome: Evidence for a transdiagnostic pathomechanism in functional somatic disorders |
| title_fullStr | Altered sensorimotor processing in irritable bowel syndrome: Evidence for a transdiagnostic pathomechanism in functional somatic disorders |
| title_full_unstemmed | Altered sensorimotor processing in irritable bowel syndrome: Evidence for a transdiagnostic pathomechanism in functional somatic disorders |
| title_short | Altered sensorimotor processing in irritable bowel syndrome: Evidence for a transdiagnostic pathomechanism in functional somatic disorders |
| title_sort | altered sensorimotor processing in irritable bowel syndrome evidence for a transdiagnostic pathomechanism in functional somatic disorders |
| topic | irritable bowel syndrome (IBS) functional somatic disorders somatoform disorders predictive processing transdiagnostic mechanism gaze shift |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.1029126/full |
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