A Sporadic and Lethal Lassa Fever Case in Forest Guinea, 2019
Lassa fever is a rodent-borne disease caused by Lassa virus (LASV). It causes fever, dizziness, vertigo, fatigue, coughing, diarrhea, internal bleeding and facial edema. The disease has been known in Guinea since 1960 but only anectodical acute cases have been reported to date. In January 2019, a 35...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/12/10/1062 |
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| author | N’Faly Magassouba Enogo Koivogui Sory Conde Moussa Kone Michel Koropogui Barrè Soropogui Ifono Kekoura Julia Hinzmann Stephan Günther Sakoba Keita Sophie Duraffour Elisabeth Fichet-Calvet |
| author_facet | N’Faly Magassouba Enogo Koivogui Sory Conde Moussa Kone Michel Koropogui Barrè Soropogui Ifono Kekoura Julia Hinzmann Stephan Günther Sakoba Keita Sophie Duraffour Elisabeth Fichet-Calvet |
| author_sort | N’Faly Magassouba |
| collection | DOAJ |
| description | Lassa fever is a rodent-borne disease caused by Lassa virus (LASV). It causes fever, dizziness, vertigo, fatigue, coughing, diarrhea, internal bleeding and facial edema. The disease has been known in Guinea since 1960 but only anectodical acute cases have been reported to date. In January 2019, a 35-year-old man, a wood merchant from Kissidougou, Forest Guinea, presented himself at several health centers with persistent fever, frequent vomiting and joint pain. He was repeatedly treated for severe malaria, and died three weeks later in Mamou regional hospital. Differential diagnosis identified LASV as the cause of death. No secondary cases were reported. The complete LASV genome was obtained using next-generation sequencing. Phylogenetic analysis showed that this strain, namely the Kissidougou strain, belongs to the clade IV circulating in Guinea and Sierra Leone, and is thought to have emerged some 150 years ago. Due to the similarity of symptoms with malaria, Lassa fever is still a disease that is difficult to recognize and that may remain undiagnosed in health centers in Guinea. |
| first_indexed | 2024-03-10T16:06:56Z |
| format | Article |
| id | doaj.art-b0f4dfbf5717447d96f0941233253ebb |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T16:06:56Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-b0f4dfbf5717447d96f0941233253ebb2023-11-20T14:50:34ZengMDPI AGViruses1999-49152020-09-011210106210.3390/v12101062A Sporadic and Lethal Lassa Fever Case in Forest Guinea, 2019N’Faly Magassouba0Enogo Koivogui1Sory Conde2Moussa Kone3Michel Koropogui4Barrè Soropogui5Ifono Kekoura6Julia Hinzmann7Stephan Günther8Sakoba Keita9Sophie Duraffour10Elisabeth Fichet-Calvet11Laboratoire des Fièvres Hémorragiques en Guinée, Conakry, GuineaAgence Nationale de Sécurité Sanitaire, Ministry of Health, Conakry, GuineaAgence Nationale de Sécurité Sanitaire, Ministry of Health, Conakry, GuineaAgence Nationale de Sécurité Sanitaire, Ministry of Health, Conakry, GuineaLaboratoire des Fièvres Hémorragiques en Guinée, Conakry, GuineaLaboratoire des Fièvres Hémorragiques en Guinée, Conakry, GuineaLaboratoire des Fièvres Hémorragiques en Guinée, Conakry, GuineaVirology Department, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, GermanyVirology Department, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, GermanyAgence Nationale de Sécurité Sanitaire, Ministry of Health, Conakry, GuineaVirology Department, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, GermanyVirology Department, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, GermanyLassa fever is a rodent-borne disease caused by Lassa virus (LASV). It causes fever, dizziness, vertigo, fatigue, coughing, diarrhea, internal bleeding and facial edema. The disease has been known in Guinea since 1960 but only anectodical acute cases have been reported to date. In January 2019, a 35-year-old man, a wood merchant from Kissidougou, Forest Guinea, presented himself at several health centers with persistent fever, frequent vomiting and joint pain. He was repeatedly treated for severe malaria, and died three weeks later in Mamou regional hospital. Differential diagnosis identified LASV as the cause of death. No secondary cases were reported. The complete LASV genome was obtained using next-generation sequencing. Phylogenetic analysis showed that this strain, namely the Kissidougou strain, belongs to the clade IV circulating in Guinea and Sierra Leone, and is thought to have emerged some 150 years ago. Due to the similarity of symptoms with malaria, Lassa fever is still a disease that is difficult to recognize and that may remain undiagnosed in health centers in Guinea.https://www.mdpi.com/1999-4915/12/10/1062Lassa feverKissidougouGuineaLassa genomephylogeny |
| spellingShingle | N’Faly Magassouba Enogo Koivogui Sory Conde Moussa Kone Michel Koropogui Barrè Soropogui Ifono Kekoura Julia Hinzmann Stephan Günther Sakoba Keita Sophie Duraffour Elisabeth Fichet-Calvet A Sporadic and Lethal Lassa Fever Case in Forest Guinea, 2019 Viruses Lassa fever Kissidougou Guinea Lassa genome phylogeny |
| title | A Sporadic and Lethal Lassa Fever Case in Forest Guinea, 2019 |
| title_full | A Sporadic and Lethal Lassa Fever Case in Forest Guinea, 2019 |
| title_fullStr | A Sporadic and Lethal Lassa Fever Case in Forest Guinea, 2019 |
| title_full_unstemmed | A Sporadic and Lethal Lassa Fever Case in Forest Guinea, 2019 |
| title_short | A Sporadic and Lethal Lassa Fever Case in Forest Guinea, 2019 |
| title_sort | sporadic and lethal lassa fever case in forest guinea 2019 |
| topic | Lassa fever Kissidougou Guinea Lassa genome phylogeny |
| url | https://www.mdpi.com/1999-4915/12/10/1062 |
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