Metabólitos secundários das esponjas Aplysina fistularis e Dysidea sp. e atividade antituberculose da 11-cetofistularina-3
The present investigation reports the isolation of aeroplysinin-2, 2-(3,5-dibromo-4-methoxyphenyl)-N,N,N-trimethyletanamonium, 7,9-dibromo-10-hydroxy-8-methoxy-1-oxa-2-azaspiro[4.5]deca-2,6,8-trien-3-carboxylic acid and its methyl ester, 11-oxoaerothionin, aerothionin, 11-keto-12-hydroxyaerothionin,...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Química
2010-01-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000900006&lng=en&tlng=en |
| _version_ | 1819230509723549696 |
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| author | Renata C. Gandolfi Marina B. Medina Roberto G. S. Berlinck Simone P. Lira Fabio Cícero de Sá Galetti Célio L. Silva Katyuscya Veloso Antonio G. Ferreira Eduardo Hajdu Solange Peixinho |
| author_facet | Renata C. Gandolfi Marina B. Medina Roberto G. S. Berlinck Simone P. Lira Fabio Cícero de Sá Galetti Célio L. Silva Katyuscya Veloso Antonio G. Ferreira Eduardo Hajdu Solange Peixinho |
| author_sort | Renata C. Gandolfi |
| collection | DOAJ |
| description | The present investigation reports the isolation of aeroplysinin-2, 2-(3,5-dibromo-4-methoxyphenyl)-N,N,N-trimethyletanamonium, 7,9-dibromo-10-hydroxy-8-methoxy-1-oxa-2-azaspiro[4.5]deca-2,6,8-trien-3-carboxylic acid and its methyl ester, 11-oxoaerothionin, aerothionin, 11-keto-12-hydroxyaerothionin, 11-ketofistularin-3 and fistularin-3 from Aplysina fistularis, as well as of furodysinin lactone and 9α,11α-epoxicholest-7-en-3β,5α,6α,10-tetrol-6-acetate from Dysidea sp. Although the extracts of both sponges displayed antituberculosis activity, only 11-ketofistularin-3 isolated from A. fistularis displayed antimycobacterial activity against Mycobacterium tuberculosis H34Rv, with MIC at 16 μg/mL and SI of 40, a result that reinforce that fistularin-3 derivatives are interesting leads for the development of antituberculosis drugs. |
| first_indexed | 2024-12-23T11:30:12Z |
| format | Article |
| id | doaj.art-b0f7c606581849458d027e598f67b768 |
| institution | Directory Open Access Journal |
| issn | 1678-7064 |
| language | English |
| last_indexed | 2024-12-23T11:30:12Z |
| publishDate | 2010-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-b0f7c606581849458d027e598f67b7682022-12-21T17:48:49ZengSociedade Brasileira de QuímicaQuímica Nova1678-70642010-01-013391853185810.1590/S0100-40422010000900006S0100-40422010000900006Metabólitos secundários das esponjas Aplysina fistularis e Dysidea sp. e atividade antituberculose da 11-cetofistularina-3Renata C. Gandolfi0Marina B. Medina1Roberto G. S. Berlinck2Simone P. Lira3Fabio Cícero de Sá Galetti4Célio L. Silva5Katyuscya Veloso6Antonio G. Ferreira7Eduardo Hajdu8Solange Peixinho9Universidade de São PauloUniversidade de São PauloUniversidade de São PauloUniversidade de São PauloFarmacore Biotecnologia LtdaFarmacore Biotecnologia LtdaUniversidade Federal de São CarlosUniversidade Federal de São CarlosUniversidade Federal do Rio de JaneiroUniversidade Federal da BahiaThe present investigation reports the isolation of aeroplysinin-2, 2-(3,5-dibromo-4-methoxyphenyl)-N,N,N-trimethyletanamonium, 7,9-dibromo-10-hydroxy-8-methoxy-1-oxa-2-azaspiro[4.5]deca-2,6,8-trien-3-carboxylic acid and its methyl ester, 11-oxoaerothionin, aerothionin, 11-keto-12-hydroxyaerothionin, 11-ketofistularin-3 and fistularin-3 from Aplysina fistularis, as well as of furodysinin lactone and 9α,11α-epoxicholest-7-en-3β,5α,6α,10-tetrol-6-acetate from Dysidea sp. Although the extracts of both sponges displayed antituberculosis activity, only 11-ketofistularin-3 isolated from A. fistularis displayed antimycobacterial activity against Mycobacterium tuberculosis H34Rv, with MIC at 16 μg/mL and SI of 40, a result that reinforce that fistularin-3 derivatives are interesting leads for the development of antituberculosis drugs.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000900006&lng=en&tlng=enmarine spongeAplysina fistularisDysidea sp. |
| spellingShingle | Renata C. Gandolfi Marina B. Medina Roberto G. S. Berlinck Simone P. Lira Fabio Cícero de Sá Galetti Célio L. Silva Katyuscya Veloso Antonio G. Ferreira Eduardo Hajdu Solange Peixinho Metabólitos secundários das esponjas Aplysina fistularis e Dysidea sp. e atividade antituberculose da 11-cetofistularina-3 Química Nova marine sponge Aplysina fistularis Dysidea sp. |
| title | Metabólitos secundários das esponjas Aplysina fistularis e Dysidea sp. e atividade antituberculose da 11-cetofistularina-3 |
| title_full | Metabólitos secundários das esponjas Aplysina fistularis e Dysidea sp. e atividade antituberculose da 11-cetofistularina-3 |
| title_fullStr | Metabólitos secundários das esponjas Aplysina fistularis e Dysidea sp. e atividade antituberculose da 11-cetofistularina-3 |
| title_full_unstemmed | Metabólitos secundários das esponjas Aplysina fistularis e Dysidea sp. e atividade antituberculose da 11-cetofistularina-3 |
| title_short | Metabólitos secundários das esponjas Aplysina fistularis e Dysidea sp. e atividade antituberculose da 11-cetofistularina-3 |
| title_sort | metabolitos secundarios das esponjas aplysina fistularis e dysidea sp e atividade antituberculose da 11 cetofistularina 3 |
| topic | marine sponge Aplysina fistularis Dysidea sp. |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000900006&lng=en&tlng=en |
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