Adult Stem Cell Therapy for Stroke: Challenges and Progress
Stroke is one of the leading causes of death and physical disability among adults. It has been 15 years since clinical trials of stem cell therapy in patients with stroke have been conducted using adult stem cells like mesenchymal stem cells and bone marrow mononuclear cells. Results of randomized c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Korean Stroke Society
2016-09-01
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| Series: | Journal of Stroke |
| Subjects: | |
| Online Access: | http://www.j-stroke.org/upload/pdf/jos-2016-01263.pdf |
| _version_ | 1818446373620547584 |
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| author | Oh Young Bang Eun Hee Kim Jae Min Cha Gyeong Joon Moon |
| author_facet | Oh Young Bang Eun Hee Kim Jae Min Cha Gyeong Joon Moon |
| author_sort | Oh Young Bang |
| collection | DOAJ |
| description | Stroke is one of the leading causes of death and physical disability among adults. It has been 15 years since clinical trials of stem cell therapy in patients with stroke have been conducted using adult stem cells like mesenchymal stem cells and bone marrow mononuclear cells. Results of randomized controlled trials showed that adult stem cell therapy was safe but its efficacy was modest, underscoring the need for new stem cell therapy strategies. The primary limitations of current stem cell therapies include (a) the limited source of engraftable stem cells, (b) the presence of optimal time window for stem cell therapies, (c) inherited limitation of stem cells in terms of growth, trophic support, and differentiation potential, and (d) possible transplanted cell-mediated adverse effects, such as tumor formation. Here, we discuss recent advances that overcome these hurdles in adult stem cell therapy for stroke. |
| first_indexed | 2024-12-14T19:46:42Z |
| format | Article |
| id | doaj.art-b0fa8fc355d142c0832400f360575b29 |
| institution | Directory Open Access Journal |
| issn | 2287-6391 2287-6405 |
| language | English |
| last_indexed | 2024-12-14T19:46:42Z |
| publishDate | 2016-09-01 |
| publisher | Korean Stroke Society |
| record_format | Article |
| series | Journal of Stroke |
| spelling | doaj.art-b0fa8fc355d142c0832400f360575b292022-12-21T22:49:33ZengKorean Stroke SocietyJournal of Stroke2287-63912287-64052016-09-0118325626610.5853/jos.2016.01263149Adult Stem Cell Therapy for Stroke: Challenges and ProgressOh Young Bang0Eun Hee Kim1Jae Min Cha2Gyeong Joon Moon3 Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Translational and Stem Cell Research Laboratory on Stroke, Samsung Medical Center, Seoul, Korea Samsung Biomedical Research Institute, Samsung Advanced Institute of Technology, Samsung Electronics Co., Ltd., Seoul, Korea Translational and Stem Cell Research Laboratory on Stroke, Samsung Medical Center, Seoul, KoreaStroke is one of the leading causes of death and physical disability among adults. It has been 15 years since clinical trials of stem cell therapy in patients with stroke have been conducted using adult stem cells like mesenchymal stem cells and bone marrow mononuclear cells. Results of randomized controlled trials showed that adult stem cell therapy was safe but its efficacy was modest, underscoring the need for new stem cell therapy strategies. The primary limitations of current stem cell therapies include (a) the limited source of engraftable stem cells, (b) the presence of optimal time window for stem cell therapies, (c) inherited limitation of stem cells in terms of growth, trophic support, and differentiation potential, and (d) possible transplanted cell-mediated adverse effects, such as tumor formation. Here, we discuss recent advances that overcome these hurdles in adult stem cell therapy for stroke.http://www.j-stroke.org/upload/pdf/jos-2016-01263.pdfstrokebiomaterialsstem cellsmesenchymal stem cells |
| spellingShingle | Oh Young Bang Eun Hee Kim Jae Min Cha Gyeong Joon Moon Adult Stem Cell Therapy for Stroke: Challenges and Progress Journal of Stroke stroke biomaterials stem cells mesenchymal stem cells |
| title | Adult Stem Cell Therapy for Stroke: Challenges and Progress |
| title_full | Adult Stem Cell Therapy for Stroke: Challenges and Progress |
| title_fullStr | Adult Stem Cell Therapy for Stroke: Challenges and Progress |
| title_full_unstemmed | Adult Stem Cell Therapy for Stroke: Challenges and Progress |
| title_short | Adult Stem Cell Therapy for Stroke: Challenges and Progress |
| title_sort | adult stem cell therapy for stroke challenges and progress |
| topic | stroke biomaterials stem cells mesenchymal stem cells |
| url | http://www.j-stroke.org/upload/pdf/jos-2016-01263.pdf |
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