Osseointegration Improvement of Co-Cr-Mo Alloy Produced by Additive Manufacturing
Cobalt-base alloys (Co-Cr-Mo) are widely employed in dentistry and orthopedic implants due to their biocompatibility, high mechanical strength and wear resistance. The osseointegration of implants can be improved by surface modification techniques. However, complex geometries obtained by additive ma...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/5/724 |
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| author | Amilton Iatecola Guilherme Arthur Longhitano Luiz Henrique Martinez Antunes André Luiz Jardini Emilio de Castro Miguel Miloslav Béreš Carlos Salles Lambert Tiago Neves Andrade Rogério Leone Buchaim Daniela Vieira Buchaim Karina Torres Pomini Jefferson Aparecido Dias Daniele Raineri Mesquita Serva Spressão Marcílio Felix Guinea Brasil Camargo Cardoso Marcelo Rodrigues da Cunha |
| author_facet | Amilton Iatecola Guilherme Arthur Longhitano Luiz Henrique Martinez Antunes André Luiz Jardini Emilio de Castro Miguel Miloslav Béreš Carlos Salles Lambert Tiago Neves Andrade Rogério Leone Buchaim Daniela Vieira Buchaim Karina Torres Pomini Jefferson Aparecido Dias Daniele Raineri Mesquita Serva Spressão Marcílio Felix Guinea Brasil Camargo Cardoso Marcelo Rodrigues da Cunha |
| author_sort | Amilton Iatecola |
| collection | DOAJ |
| description | Cobalt-base alloys (Co-Cr-Mo) are widely employed in dentistry and orthopedic implants due to their biocompatibility, high mechanical strength and wear resistance. The osseointegration of implants can be improved by surface modification techniques. However, complex geometries obtained by additive manufacturing (AM) limits the efficiency of mechanical-based surface modification techniques. Therefore, plasma immersion ion implantation (PIII) is the best alternative, creating nanotopography even in complex structures. In the present study, we report the osseointegration results in three conditions of the additively manufactured Co-Cr-Mo alloy: (i) as-built, (ii) after PIII, and (iii) coated with titanium (Ti) followed by PIII. The metallic samples were designed with a solid half and a porous half to observe the bone ingrowth in different surfaces. Our results revealed that all conditions presented cortical bone formation. The titanium-coated sample exhibited the best biomechanical results, which was attributed to the higher bone ingrowth percentage with almost all medullary canals filled with neoformed bone and the pores of the implant filled and surrounded by bone ingrowth. It was concluded that the metal alloys produced for AM are biocompatible and stimulate bone neoformation, especially when the Co-28Cr-6Mo alloy with a Ti-coated surface, nanostructured and anodized by PIII is used, whose technology has been shown to increase the osseointegration capacity of this implant. |
| first_indexed | 2024-03-10T11:24:13Z |
| format | Article |
| id | doaj.art-b0faa3bd747e4a10a2bbad1916f093bf |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T11:24:13Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-b0faa3bd747e4a10a2bbad1916f093bf2023-11-21T19:49:48ZengMDPI AGPharmaceutics1999-49232021-05-0113572410.3390/pharmaceutics13050724Osseointegration Improvement of Co-Cr-Mo Alloy Produced by Additive ManufacturingAmilton Iatecola0Guilherme Arthur Longhitano1Luiz Henrique Martinez Antunes2André Luiz Jardini3Emilio de Castro Miguel4Miloslav Béreš5Carlos Salles Lambert6Tiago Neves Andrade7Rogério Leone Buchaim8Daniela Vieira Buchaim9Karina Torres Pomini10Jefferson Aparecido Dias11Daniele Raineri Mesquita Serva Spressão12Marcílio Felix13Guinea Brasil Camargo Cardoso14Marcelo Rodrigues da Cunha15Faculty of Medicine of Jundiaí, Jundiaí 13202-550, São Paulo, BrazilCenter for Information Technology Renato Archer (CTI), Campinas 13069-901, São Paulo, BrazilNational Institute of Biofabrication (INCT-BIOFABRIS), Campinas 13083-852, São Paulo, BrazilNational Institute of Biofabrication (INCT-BIOFABRIS), Campinas 13083-852, São Paulo, BrazilDepartment of Metallurgical and Materials Engineering, Federal University of Ceará, Fortaleza 60440-554, Ceará, BrazilNational Institute of Biofabrication (INCT-BIOFABRIS), Campinas 13083-852, São Paulo, Brazil“Gleb Wataghin” Institute of Physics, University of Campinas (UNICAMP), Campinas 13083-859, São Paulo, BrazilFaculty of Medicine of Jundiaí, Jundiaí 13202-550, São Paulo, BrazilDepartment of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of São Paulo, Bauru 17012-901, São Paulo, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Marília 17525-902, São Paulo, BrazilDepartment of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of São Paulo, Bauru 17012-901, São Paulo, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Marília 17525-902, São Paulo, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Marília 17525-902, São Paulo, BrazilVeterinary Medicine School, University of Marilia (UNIMAR), Marília 17525-902, São Paulo, BrazilSchool of Mechanical Engineering, University of Campinas (UNICAMP), Campinas 13083-860, São Paulo, BrazilFaculty of Medicine of Jundiaí, Jundiaí 13202-550, São Paulo, BrazilCobalt-base alloys (Co-Cr-Mo) are widely employed in dentistry and orthopedic implants due to their biocompatibility, high mechanical strength and wear resistance. The osseointegration of implants can be improved by surface modification techniques. However, complex geometries obtained by additive manufacturing (AM) limits the efficiency of mechanical-based surface modification techniques. Therefore, plasma immersion ion implantation (PIII) is the best alternative, creating nanotopography even in complex structures. In the present study, we report the osseointegration results in three conditions of the additively manufactured Co-Cr-Mo alloy: (i) as-built, (ii) after PIII, and (iii) coated with titanium (Ti) followed by PIII. The metallic samples were designed with a solid half and a porous half to observe the bone ingrowth in different surfaces. Our results revealed that all conditions presented cortical bone formation. The titanium-coated sample exhibited the best biomechanical results, which was attributed to the higher bone ingrowth percentage with almost all medullary canals filled with neoformed bone and the pores of the implant filled and surrounded by bone ingrowth. It was concluded that the metal alloys produced for AM are biocompatible and stimulate bone neoformation, especially when the Co-28Cr-6Mo alloy with a Ti-coated surface, nanostructured and anodized by PIII is used, whose technology has been shown to increase the osseointegration capacity of this implant.https://www.mdpi.com/1999-4923/13/5/724additive manufacturingplasma immersion ion implantationCo-Cr-Mo alloyosseointegrationorthopedic implants |
| spellingShingle | Amilton Iatecola Guilherme Arthur Longhitano Luiz Henrique Martinez Antunes André Luiz Jardini Emilio de Castro Miguel Miloslav Béreš Carlos Salles Lambert Tiago Neves Andrade Rogério Leone Buchaim Daniela Vieira Buchaim Karina Torres Pomini Jefferson Aparecido Dias Daniele Raineri Mesquita Serva Spressão Marcílio Felix Guinea Brasil Camargo Cardoso Marcelo Rodrigues da Cunha Osseointegration Improvement of Co-Cr-Mo Alloy Produced by Additive Manufacturing Pharmaceutics additive manufacturing plasma immersion ion implantation Co-Cr-Mo alloy osseointegration orthopedic implants |
| title | Osseointegration Improvement of Co-Cr-Mo Alloy Produced by Additive Manufacturing |
| title_full | Osseointegration Improvement of Co-Cr-Mo Alloy Produced by Additive Manufacturing |
| title_fullStr | Osseointegration Improvement of Co-Cr-Mo Alloy Produced by Additive Manufacturing |
| title_full_unstemmed | Osseointegration Improvement of Co-Cr-Mo Alloy Produced by Additive Manufacturing |
| title_short | Osseointegration Improvement of Co-Cr-Mo Alloy Produced by Additive Manufacturing |
| title_sort | osseointegration improvement of co cr mo alloy produced by additive manufacturing |
| topic | additive manufacturing plasma immersion ion implantation Co-Cr-Mo alloy osseointegration orthopedic implants |
| url | https://www.mdpi.com/1999-4923/13/5/724 |
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