Schisandrin alleviates the cognitive impairment in rats with Alzheimer’s disease by altering the gut microbiota composition to modulate the levels of endogenous metabolites in the plasma, brain, and feces

Schisandrin alleviates the cognitive impairment in rats with Alzheimer’s disease by altering the gut microbiota composition to modulate the levels of endogenous metabolites in the plasma, brain, and feces

Schisandrin is one of the main active compounds isolated from the fruit of Schisandrae chinensis Fructus, which is scientifically proven to have beneficial effects on Alzheimer’s disease (AD) treatment at the cellular and whole organism level. However, the oral availability of schisandrin is very lo...

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Bibliographic Details
Main Authors: Chengqin Zhang, Ying Zhang, Tiantian Zhao, Tingting Mou, Wang Jing, Jian Chen, Wenqian Hao, Shuo Gu, Meirong Cui, Yue Sun, Binbin Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
Alzheimer’s disease
schisandrin
gut microbiota
metabolomics
16S rRNA gene sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.888726/full

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