CircSETDB1 knockdown inhibits the malignant progression of serous ovarian cancer through miR-129-3p-dependent regulation of MAP3K3
Highlights 1. CircSETDB1 expression was increased in SOC tissues and cells. 2. CircSETDB1 silencing repressed the malignancy of SOC cells. 3. CircSETDB1 mediated SOC malignant progression by interacting with miR-129-3p. 4. MAP3K3 served as a target gene of miR-129-3p. 5. CircSETDB1 knockdown inhibit...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-11-01
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| Series: | Journal of Ovarian Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13048-021-00875-0 |
| _version_ | 1797972818754797568 |
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| author | Bo Li Lu Zhang |
| author_facet | Bo Li Lu Zhang |
| author_sort | Bo Li |
| collection | DOAJ |
| description | Highlights 1. CircSETDB1 expression was increased in SOC tissues and cells. 2. CircSETDB1 silencing repressed the malignancy of SOC cells. 3. CircSETDB1 mediated SOC malignant progression by interacting with miR-129-3p. 4. MAP3K3 served as a target gene of miR-129-3p. 5. CircSETDB1 knockdown inhibited tumor formation in vivo. |
| first_indexed | 2024-04-11T03:54:28Z |
| format | Article |
| id | doaj.art-b0fb692d7fab44ccaf779d0d784c3dc1 |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-04-11T03:54:28Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-b0fb692d7fab44ccaf779d0d784c3dc12023-01-02T01:03:22ZengBMCJournal of Ovarian Research1757-22152021-11-0114111510.1186/s13048-021-00875-0CircSETDB1 knockdown inhibits the malignant progression of serous ovarian cancer through miR-129-3p-dependent regulation of MAP3K3Bo Li0Lu Zhang1Department of Gynaecology, Yantaishan HospitalDepartment of Gynaecology, Yantaishan HospitalHighlights 1. CircSETDB1 expression was increased in SOC tissues and cells. 2. CircSETDB1 silencing repressed the malignancy of SOC cells. 3. CircSETDB1 mediated SOC malignant progression by interacting with miR-129-3p. 4. MAP3K3 served as a target gene of miR-129-3p. 5. CircSETDB1 knockdown inhibited tumor formation in vivo.https://doi.org/10.1186/s13048-021-00875-0SOCcircSETDB1miR-129-3pMAP3K3 |
| spellingShingle | Bo Li Lu Zhang CircSETDB1 knockdown inhibits the malignant progression of serous ovarian cancer through miR-129-3p-dependent regulation of MAP3K3 Journal of Ovarian Research SOC circSETDB1 miR-129-3p MAP3K3 |
| title | CircSETDB1 knockdown inhibits the malignant progression of serous ovarian cancer through miR-129-3p-dependent regulation of MAP3K3 |
| title_full | CircSETDB1 knockdown inhibits the malignant progression of serous ovarian cancer through miR-129-3p-dependent regulation of MAP3K3 |
| title_fullStr | CircSETDB1 knockdown inhibits the malignant progression of serous ovarian cancer through miR-129-3p-dependent regulation of MAP3K3 |
| title_full_unstemmed | CircSETDB1 knockdown inhibits the malignant progression of serous ovarian cancer through miR-129-3p-dependent regulation of MAP3K3 |
| title_short | CircSETDB1 knockdown inhibits the malignant progression of serous ovarian cancer through miR-129-3p-dependent regulation of MAP3K3 |
| title_sort | circsetdb1 knockdown inhibits the malignant progression of serous ovarian cancer through mir 129 3p dependent regulation of map3k3 |
| topic | SOC circSETDB1 miR-129-3p MAP3K3 |
| url | https://doi.org/10.1186/s13048-021-00875-0 |
| work_keys_str_mv | AT boli circsetdb1knockdowninhibitsthemalignantprogressionofserousovariancancerthroughmir1293pdependentregulationofmap3k3 AT luzhang circsetdb1knockdowninhibitsthemalignantprogressionofserousovariancancerthroughmir1293pdependentregulationofmap3k3 |