Pharmacological and Nutritional Modulation of Metabolome and Metagenome in Cardiometabolic Disorders
Cardiometabolic disorders are major causes of morbidity and mortality worldwide. A growing body of research indicates that the gut microbiota, whether it interacts favorably or not, plays an important role in host metabolism. Elucidating metabolic pathways may be crucial in preventing and treating c...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/9/1340 |
| _version_ | 1797581117714333696 |
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| author | Anna Maria Witkowska Joe-Elie Salem |
| author_facet | Anna Maria Witkowska Joe-Elie Salem |
| author_sort | Anna Maria Witkowska |
| collection | DOAJ |
| description | Cardiometabolic disorders are major causes of morbidity and mortality worldwide. A growing body of research indicates that the gut microbiota, whether it interacts favorably or not, plays an important role in host metabolism. Elucidating metabolic pathways may be crucial in preventing and treating cardiometabolic diseases, and omics methods are key to studying the interaction between the fecal microbiota and host metabolism. This review summarizes available studies that combine metabolomic and metagenomic approaches to describe the effects of drugs, diet, nutrients, and specific foods on cardiometabolic health and to identify potential targets for future research. |
| first_indexed | 2024-03-10T22:59:38Z |
| format | Article |
| id | doaj.art-b0fb936a48a340dea526cc8df1240c34 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T22:59:38Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-b0fb936a48a340dea526cc8df1240c342023-11-19T09:45:37ZengMDPI AGBiomolecules2218-273X2023-09-01139134010.3390/biom13091340Pharmacological and Nutritional Modulation of Metabolome and Metagenome in Cardiometabolic DisordersAnna Maria Witkowska0Joe-Elie Salem1Department of Food Biotechnology, Faculty of Health Sciences, Medical University of Bialystok, Szpitalna 37, 15-295 Białystok, PolandDepartment of Pharmacology, Pitié-Salpêtrière Hospital, Institut National de la Santé et de la Recherche Médicale (INSERM), Clinical Investigation Center (CIC-1901), Assistance Publique-Hôpitaux de Paris (AP-HP), Sorbonne Université, 75013 Paris, FranceCardiometabolic disorders are major causes of morbidity and mortality worldwide. A growing body of research indicates that the gut microbiota, whether it interacts favorably or not, plays an important role in host metabolism. Elucidating metabolic pathways may be crucial in preventing and treating cardiometabolic diseases, and omics methods are key to studying the interaction between the fecal microbiota and host metabolism. This review summarizes available studies that combine metabolomic and metagenomic approaches to describe the effects of drugs, diet, nutrients, and specific foods on cardiometabolic health and to identify potential targets for future research.https://www.mdpi.com/2218-273X/13/9/1340cardiometabolicdrugsfoodsupplementdietnutrition |
| spellingShingle | Anna Maria Witkowska Joe-Elie Salem Pharmacological and Nutritional Modulation of Metabolome and Metagenome in Cardiometabolic Disorders Biomolecules cardiometabolic drugs food supplement diet nutrition |
| title | Pharmacological and Nutritional Modulation of Metabolome and Metagenome in Cardiometabolic Disorders |
| title_full | Pharmacological and Nutritional Modulation of Metabolome and Metagenome in Cardiometabolic Disorders |
| title_fullStr | Pharmacological and Nutritional Modulation of Metabolome and Metagenome in Cardiometabolic Disorders |
| title_full_unstemmed | Pharmacological and Nutritional Modulation of Metabolome and Metagenome in Cardiometabolic Disorders |
| title_short | Pharmacological and Nutritional Modulation of Metabolome and Metagenome in Cardiometabolic Disorders |
| title_sort | pharmacological and nutritional modulation of metabolome and metagenome in cardiometabolic disorders |
| topic | cardiometabolic drugs food supplement diet nutrition |
| url | https://www.mdpi.com/2218-273X/13/9/1340 |
| work_keys_str_mv | AT annamariawitkowska pharmacologicalandnutritionalmodulationofmetabolomeandmetagenomeincardiometabolicdisorders AT joeeliesalem pharmacologicalandnutritionalmodulationofmetabolomeandmetagenomeincardiometabolicdisorders |