Modulation by luminal factors on the functions and migration of intestinal innate immunity
Luminal antigens, nutrients, metabolites from commensal bacteria, bile acids, or neuropeptides influence the function and trafficking of immune cells in the intestine. Among the immune cells in the gut, innate lymphoid cells, including macrophages, neutrophils, dendritic cells, mast cells, and innat...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1113467/full |
| _version_ | 1811165355559616512 |
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| author | Masaaki Higashiyama Soichiro Miura Ryota Hokari |
| author_facet | Masaaki Higashiyama Soichiro Miura Ryota Hokari |
| author_sort | Masaaki Higashiyama |
| collection | DOAJ |
| description | Luminal antigens, nutrients, metabolites from commensal bacteria, bile acids, or neuropeptides influence the function and trafficking of immune cells in the intestine. Among the immune cells in the gut, innate lymphoid cells, including macrophages, neutrophils, dendritic cells, mast cells, and innate lymphoid cells, play an important role for the maintenance of intestinal homeostasis through a rapid immune response to luminal pathogens. These innate cells are influenced by several luminal factors, possibly leading to dysregulated gut immunity and intestinal disorders such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and intestinal allergy. Luminal factors are sensed by distinct neuro-immune cell units, which also have a strong impact on immunoregulation of the gut. Immune cell trafficking from the blood stream through the lymphatic organ to lymphatics, an essential function for immune responses, is also modulated by luminal factors. This mini-review examines knowledge of luminal and neural factors that regulate and modulate response and migration of leukocytes including innate immune cells, some of which are clinically associated with pathological intestinal inflammation. |
| first_indexed | 2024-04-10T15:35:56Z |
| format | Article |
| id | doaj.art-b0fc7bc78f9e4b5ba2991afaa903c977 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T15:35:56Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b0fc7bc78f9e4b5ba2991afaa903c9772023-02-13T06:54:03ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-02-011410.3389/fimmu.2023.11134671113467Modulation by luminal factors on the functions and migration of intestinal innate immunityMasaaki Higashiyama0Soichiro Miura1Ryota Hokari2Department of Internal Medicine, National Defense Medical College, Tokorozawa, JapanInternational University of Health and Welfare, Tokyo, JapanDepartment of Internal Medicine, National Defense Medical College, Tokorozawa, JapanLuminal antigens, nutrients, metabolites from commensal bacteria, bile acids, or neuropeptides influence the function and trafficking of immune cells in the intestine. Among the immune cells in the gut, innate lymphoid cells, including macrophages, neutrophils, dendritic cells, mast cells, and innate lymphoid cells, play an important role for the maintenance of intestinal homeostasis through a rapid immune response to luminal pathogens. These innate cells are influenced by several luminal factors, possibly leading to dysregulated gut immunity and intestinal disorders such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and intestinal allergy. Luminal factors are sensed by distinct neuro-immune cell units, which also have a strong impact on immunoregulation of the gut. Immune cell trafficking from the blood stream through the lymphatic organ to lymphatics, an essential function for immune responses, is also modulated by luminal factors. This mini-review examines knowledge of luminal and neural factors that regulate and modulate response and migration of leukocytes including innate immune cells, some of which are clinically associated with pathological intestinal inflammation.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1113467/fullleukocytesinnate immunityluminal factorsneuropeptidesmigrationgut immunity |
| spellingShingle | Masaaki Higashiyama Soichiro Miura Ryota Hokari Modulation by luminal factors on the functions and migration of intestinal innate immunity Frontiers in Immunology leukocytes innate immunity luminal factors neuropeptides migration gut immunity |
| title | Modulation by luminal factors on the functions and migration of intestinal innate immunity |
| title_full | Modulation by luminal factors on the functions and migration of intestinal innate immunity |
| title_fullStr | Modulation by luminal factors on the functions and migration of intestinal innate immunity |
| title_full_unstemmed | Modulation by luminal factors on the functions and migration of intestinal innate immunity |
| title_short | Modulation by luminal factors on the functions and migration of intestinal innate immunity |
| title_sort | modulation by luminal factors on the functions and migration of intestinal innate immunity |
| topic | leukocytes innate immunity luminal factors neuropeptides migration gut immunity |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1113467/full |
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