Crystal structure of human METTL6, the m3C methyltransferase
Ran Chen et al. report the crystal structure of human m3C methyltrasfease METTL6. They generate structure models of hMETTL6 in complex with substrates, providing important insight into the molecular recognition mechanism by METTL6 and may aid in the METTL-based rational drug design in the future.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-12-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02890-9 |
| _version_ | 1818573867325587456 |
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| author | Ran Chen Jie Zhou Ling Liu Xue-Ling Mao Xiaolong Zhou Wei Xie |
| author_facet | Ran Chen Jie Zhou Ling Liu Xue-Ling Mao Xiaolong Zhou Wei Xie |
| author_sort | Ran Chen |
| collection | DOAJ |
| description | Ran Chen et al. report the crystal structure of human m3C methyltrasfease METTL6. They generate structure models of hMETTL6 in complex with substrates, providing important insight into the molecular recognition mechanism by METTL6 and may aid in the METTL-based rational drug design in the future. |
| first_indexed | 2024-12-15T00:18:38Z |
| format | Article |
| id | doaj.art-b0fe700029b24643a4a01b21bcf67940 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-15T00:18:38Z |
| publishDate | 2021-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-b0fe700029b24643a4a01b21bcf679402022-12-21T22:42:23ZengNature PortfolioCommunications Biology2399-36422021-12-014111010.1038/s42003-021-02890-9Crystal structure of human METTL6, the m3C methyltransferaseRan Chen0Jie Zhou1Ling Liu2Xue-Ling Mao3Xiaolong Zhou4Wei Xie5MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences, The Sun Yat-Sen UniversityMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences, The Sun Yat-Sen UniversityMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences, The Sun Yat-Sen UniversityState Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of SciencesState Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of SciencesMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences, The Sun Yat-Sen UniversityRan Chen et al. report the crystal structure of human m3C methyltrasfease METTL6. They generate structure models of hMETTL6 in complex with substrates, providing important insight into the molecular recognition mechanism by METTL6 and may aid in the METTL-based rational drug design in the future.https://doi.org/10.1038/s42003-021-02890-9 |
| spellingShingle | Ran Chen Jie Zhou Ling Liu Xue-Ling Mao Xiaolong Zhou Wei Xie Crystal structure of human METTL6, the m3C methyltransferase Communications Biology |
| title | Crystal structure of human METTL6, the m3C methyltransferase |
| title_full | Crystal structure of human METTL6, the m3C methyltransferase |
| title_fullStr | Crystal structure of human METTL6, the m3C methyltransferase |
| title_full_unstemmed | Crystal structure of human METTL6, the m3C methyltransferase |
| title_short | Crystal structure of human METTL6, the m3C methyltransferase |
| title_sort | crystal structure of human mettl6 the m3c methyltransferase |
| url | https://doi.org/10.1038/s42003-021-02890-9 |
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