Development of targeted therapies in treatment of glioblastoma
Glioblastoma (GBM) is a type of tumor that is highly lethal despite maximal therapy. Standard therapeutic approaches provide modest improvement in progression-free and overall survival, necessitating the investigation of novel therapies. Oncologic therapy has recently experienced a rapid evolution t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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China Anti-Cancer Association
2015-09-01
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| Series: | Cancer Biology & Medicine |
| Subjects: | |
| Online Access: | http://www.cancerbiomed.org/index.php/cocr/article/view/874 |
| _version_ | 1819263581113286656 |
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| author | Yuan-Yuan Xu Pei Gao Ying Sun You-Rong Duan |
| author_facet | Yuan-Yuan Xu Pei Gao Ying Sun You-Rong Duan |
| author_sort | Yuan-Yuan Xu |
| collection | DOAJ |
| description | Glioblastoma (GBM) is a type of tumor that is highly lethal despite maximal therapy. Standard therapeutic approaches provide modest improvement in progression-free and overall survival, necessitating the investigation of novel therapies. Oncologic therapy has recently experienced a rapid evolution toward "targeted therapy", with drugs directed against specific targets which play essential roles in the proliferation, survival, and invasiveness of GBM cells, including numerous molecules involved in signal transduction pathways. Inhibitors of these molecules have already entered or are undergoing clinical trials. However, significant challenges in their development remain because several preclinical and clinical studies present conflicting results. In this article, we will provide an up-to-date review of the current targeted therapies in GBM. |
| first_indexed | 2024-12-23T20:15:52Z |
| format | Article |
| id | doaj.art-b0ff953aa53140479af5a9653cab316e |
| institution | Directory Open Access Journal |
| issn | 2095-3941 2095-3941 |
| language | English |
| last_indexed | 2024-12-23T20:15:52Z |
| publishDate | 2015-09-01 |
| publisher | China Anti-Cancer Association |
| record_format | Article |
| series | Cancer Biology & Medicine |
| spelling | doaj.art-b0ff953aa53140479af5a9653cab316e2022-12-21T17:32:42ZengChina Anti-Cancer AssociationCancer Biology & Medicine2095-39412095-39412015-09-0112322323710.7497/j.issn.2095-3941.2015.00202015000020Development of targeted therapies in treatment of glioblastomaYuan-Yuan Xu0Pei Gao1Ying Sun2You-Rong Duan3State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200032, ChinaState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200032, ChinaState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200032, ChinaState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200032, ChinaGlioblastoma (GBM) is a type of tumor that is highly lethal despite maximal therapy. Standard therapeutic approaches provide modest improvement in progression-free and overall survival, necessitating the investigation of novel therapies. Oncologic therapy has recently experienced a rapid evolution toward "targeted therapy", with drugs directed against specific targets which play essential roles in the proliferation, survival, and invasiveness of GBM cells, including numerous molecules involved in signal transduction pathways. Inhibitors of these molecules have already entered or are undergoing clinical trials. However, significant challenges in their development remain because several preclinical and clinical studies present conflicting results. In this article, we will provide an up-to-date review of the current targeted therapies in GBM.http://www.cancerbiomed.org/index.php/cocr/article/view/874Glioblastoma (GBM)targeted therapyblood-brain barrier (BBB)clinical trial |
| spellingShingle | Yuan-Yuan Xu Pei Gao Ying Sun You-Rong Duan Development of targeted therapies in treatment of glioblastoma Cancer Biology & Medicine Glioblastoma (GBM) targeted therapy blood-brain barrier (BBB) clinical trial |
| title | Development of targeted therapies in treatment of glioblastoma |
| title_full | Development of targeted therapies in treatment of glioblastoma |
| title_fullStr | Development of targeted therapies in treatment of glioblastoma |
| title_full_unstemmed | Development of targeted therapies in treatment of glioblastoma |
| title_short | Development of targeted therapies in treatment of glioblastoma |
| title_sort | development of targeted therapies in treatment of glioblastoma |
| topic | Glioblastoma (GBM) targeted therapy blood-brain barrier (BBB) clinical trial |
| url | http://www.cancerbiomed.org/index.php/cocr/article/view/874 |
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