Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing

Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing

Copy number alterations (CNAs) play an important role in molding the genomes of breast cancers and have been shown to be clinically useful for prognostic and therapeutic purposes. However, our knowledge of intra-tumoral genetic heterogeneity of this important class of somatic alterations is limited....

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Bibliographic Details
Main Authors: Timour Baslan, Jude Kendall, Konstantin Volyanskyy, Katherine McNamara, Hilary Cox, Sean D'Italia, Frank Ambrosio, Michael Riggs, Linda Rodgers, Anthony Leotta, Junyan Song, Yong Mao, Jie Wu, Ronak Shah, Rodrigo Gularte-Mérida, Kalyani Chadalavada, Gouri Nanjangud, Vinay Varadan, Assaf Gordon, Christina Curtis, Alex Krasnitz, Nevenka Dimitrova, Lyndsay Harris, Michael Wigler, James Hicks
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-05-01
Series:eLife
Subjects:
cancer
genomics
single-cell sequencing
copy number alterations
genetics
breast cancer
Online Access:https://elifesciences.org/articles/51480

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