Tenuous transcriptional threshold of human sex determination. II. SRY exploits water-mediated clamp at the edge of ambiguity

Tenuous transcriptional threshold of human sex determination. II. SRY exploits water-mediated clamp at the edge of ambiguity

Y-encoded transcription factor SRY initiates male differentiation in therian mammals. This factor contains a high-mobility-group (HMG) box, which mediates sequence-specific DNA binding with sharp DNA bending. A companion article in this issue described sex-reversal mutations at box position 72 (resi...

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Bibliographic Details
Main Authors: Joseph D. Racca, Deepak Chatterjee, Yen-Shan Chen, Ratan K. Rai, Yanwu Yang, Millie M. Georgiadis, Elisha Haas, Michael A. Weiss
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Endocrinology
Subjects:
DNA dynamics
nucleic-acid recognition
DNA intercalation
protein hydration
indirect readout
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.1029177/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.1029177/full

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