Tenuous transcriptional threshold of human sex determination. II. SRY exploits water-mediated clamp at the edge of ambiguity
Y-encoded transcription factor SRY initiates male differentiation in therian mammals. This factor contains a high-mobility-group (HMG) box, which mediates sequence-specific DNA binding with sharp DNA bending. A companion article in this issue described sex-reversal mutations at box position 72 (resi...
Main Authors: | Joseph D. Racca, Deepak Chatterjee, Yen-Shan Chen, Ratan K. Rai, Yanwu Yang, Millie M. Georgiadis, Elisha Haas, Michael A. Weiss |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-12-01
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Series: | Frontiers in Endocrinology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1029177/full |
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