Association patterns of volatile metabolites in urinary excretions among Type-2 Non-Insulin dependent diabetes patients
Background: Patterns of volatile metabolites in urine are important to detect abnormalities associated with diabetes. Present study was conducted to find out the excretion patterns of endogenously produced alcohols in urine for type 2 (Non-Insulin Dependent) diabetes mellitus. A cross sectional anal...
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| Format: | Article |
| Language: | English |
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The Running Line
2016-05-01
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| Series: | Advancements in Life Sciences |
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| Online Access: | http://www.als-journal.com/331.16/ |
| _version_ | 1797708012265144320 |
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| author | Muhammad Saqib Shahzad Javed Iqbal Bajwa Javed Iqbal Wattoo Mushtaq A Saleem |
| author_facet | Muhammad Saqib Shahzad Javed Iqbal Bajwa Javed Iqbal Wattoo Mushtaq A Saleem |
| author_sort | Muhammad Saqib Shahzad |
| collection | DOAJ |
| description | Background: Patterns of volatile metabolites in urine are important to detect abnormalities associated with diabetes. Present study was conducted to find out the excretion patterns of endogenously produced alcohols in urine for type 2 (Non-Insulin Dependent) diabetes mellitus. A cross sectional analytical study was conducted with duration extended from Jan to Mar 2015.
Methods: The current study included 40 patients with chronic type 2 diabetes mellitus. In total, 10 sex and age matched subjects with no history of any disease were considered as controls. Blood sugar was estimated by autoanalyzer using standard kit of Merck following manufacturer`s instructions. Urine sugar was quantitatively detected by biuret reagent using titration technique. Urinary alcohol was identified and estimated by gas chromatography. Urinary ketone bodies were estimated by urinary strip.
Results: It was observed that level of fasting blood sugar was significantly increased (P<0.001) in patients as compared to their controls. The blood sugar and urinary alcohol in patients were 3.0% and 6.0% respectively. Urinary ketone bodies were found to be 2+. On the other hand urine sugar, alcohol and ketone bodies were not detected in the negative control subjects.
Conclusions: It is concluded that urinary alcohol is endogenously produced in patients with type 2 diabetes due to uncontrolled hyperglycemia. However further work is needed to find out the ratio of urinary and blood alcohol which may confirm the present findings. |
| first_indexed | 2024-03-12T06:15:01Z |
| format | Article |
| id | doaj.art-b10104f3f65f4dddbd29bce2bd208a90 |
| institution | Directory Open Access Journal |
| issn | 2310-5380 2310-5380 |
| language | English |
| last_indexed | 2024-03-12T06:15:01Z |
| publishDate | 2016-05-01 |
| publisher | The Running Line |
| record_format | Article |
| series | Advancements in Life Sciences |
| spelling | doaj.art-b10104f3f65f4dddbd29bce2bd208a902023-09-03T02:41:18ZengThe Running LineAdvancements in Life Sciences2310-53802310-53802016-05-01337174Association patterns of volatile metabolites in urinary excretions among Type-2 Non-Insulin dependent diabetes patientsMuhammad Saqib Shahzad0Javed Iqbal Bajwa1Javed Iqbal Wattoo2Mushtaq A Saleem3Faculty of Life Sciences, University of Central Punjab, Lahore –PakistanFaculty of Dentistry, Punjab Medical College, Faisalabad – PakistanFaculty of Life Sciences, University of Central Punjab, Lahore –PakistanFaculty of Life Sciences, University of Central Punjab, Lahore –PakistanBackground: Patterns of volatile metabolites in urine are important to detect abnormalities associated with diabetes. Present study was conducted to find out the excretion patterns of endogenously produced alcohols in urine for type 2 (Non-Insulin Dependent) diabetes mellitus. A cross sectional analytical study was conducted with duration extended from Jan to Mar 2015. Methods: The current study included 40 patients with chronic type 2 diabetes mellitus. In total, 10 sex and age matched subjects with no history of any disease were considered as controls. Blood sugar was estimated by autoanalyzer using standard kit of Merck following manufacturer`s instructions. Urine sugar was quantitatively detected by biuret reagent using titration technique. Urinary alcohol was identified and estimated by gas chromatography. Urinary ketone bodies were estimated by urinary strip. Results: It was observed that level of fasting blood sugar was significantly increased (P<0.001) in patients as compared to their controls. The blood sugar and urinary alcohol in patients were 3.0% and 6.0% respectively. Urinary ketone bodies were found to be 2+. On the other hand urine sugar, alcohol and ketone bodies were not detected in the negative control subjects. Conclusions: It is concluded that urinary alcohol is endogenously produced in patients with type 2 diabetes due to uncontrolled hyperglycemia. However further work is needed to find out the ratio of urinary and blood alcohol which may confirm the present findings.http://www.als-journal.com/331.16/Urinary alcoholUrinary sugardiabetes mellitusNon-insulin dependent patientType 2 diabetes |
| spellingShingle | Muhammad Saqib Shahzad Javed Iqbal Bajwa Javed Iqbal Wattoo Mushtaq A Saleem Association patterns of volatile metabolites in urinary excretions among Type-2 Non-Insulin dependent diabetes patients Advancements in Life Sciences Urinary alcohol Urinary sugar diabetes mellitus Non-insulin dependent patient Type 2 diabetes |
| title | Association patterns of volatile metabolites in urinary excretions among Type-2 Non-Insulin dependent diabetes patients |
| title_full | Association patterns of volatile metabolites in urinary excretions among Type-2 Non-Insulin dependent diabetes patients |
| title_fullStr | Association patterns of volatile metabolites in urinary excretions among Type-2 Non-Insulin dependent diabetes patients |
| title_full_unstemmed | Association patterns of volatile metabolites in urinary excretions among Type-2 Non-Insulin dependent diabetes patients |
| title_short | Association patterns of volatile metabolites in urinary excretions among Type-2 Non-Insulin dependent diabetes patients |
| title_sort | association patterns of volatile metabolites in urinary excretions among type 2 non insulin dependent diabetes patients |
| topic | Urinary alcohol Urinary sugar diabetes mellitus Non-insulin dependent patient Type 2 diabetes |
| url | http://www.als-journal.com/331.16/ |
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