Kamikihito improves cancer-related fatigue by restoring balance between the sympathetic and parasympathetic nervous systems
Background: Cancer-related fatigue is one of the most prevalent symptoms that patients with cancer experience, but the mechanisms underlying it are unknown. We aimed to quantify and mechanistically evaluate the improvement in fatigue related to administration of the Kampo medicine, Kamikihito. Mater...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-06-01
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| Series: | Prostate International |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2287888217301484 |
| _version_ | 1797763656786640896 |
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| author | Satoshi Tamada Kyoko Ebisu Sayaka Yasuda Minoru Kato Noriko Ninomiya Takeshi Yamasaki Taro Iguchi Tatsuya Nakatani Yasuyoshi Watanabe |
| author_facet | Satoshi Tamada Kyoko Ebisu Sayaka Yasuda Minoru Kato Noriko Ninomiya Takeshi Yamasaki Taro Iguchi Tatsuya Nakatani Yasuyoshi Watanabe |
| author_sort | Satoshi Tamada |
| collection | DOAJ |
| description | Background: Cancer-related fatigue is one of the most prevalent symptoms that patients with cancer experience, but the mechanisms underlying it are unknown. We aimed to quantify and mechanistically evaluate the improvement in fatigue related to administration of the Kampo medicine, Kamikihito. Materials and methods: Initially, we recruited outpatients with urological diseases and compared fatigue levels of 37 patients with cancer with a control group of 23 volunteers who had recovered completely from cancer or who were being treated for dysuria. Fatigue level was estimated using an autonomic function analyzer. Then, Kamikihito was administered to another 35 patients treated with hormone or antitumor therapy for prostate cancer and metastatic renal cell cancer. Subjective fatigue and other problems of the patients were assessed using the Chalder fatigue scale, the Center for Epidemiologic Studies Depression scale, and the Epworth sleepiness scale. Serum levels of derivatives of reactive oxygen species and biological antioxidant potential were also measured. Results: Patients in the cancer treatment group experienced more fatigue compared with the control patients when evaluated using an autonomic function analyzer. The group of 35 patients who were administered Kamikihito showed improved scores for fatigue, depression, and sleepiness. Autonomic nervous system balance was also improved with Kamikihito administration. The Kamikihito group also had significantly lower reactive oxygen species metabolite levels and significantly higher antioxidant potential. Conclusions: Fatigue was more serious in patients with cancer than in control patients. Kamikihito rescued this fatigue and improved anxiety and sleepiness. It restored autonomic nervous system balance and antioxidant function. Keywords: Autonomic nerve system, Cancer-related fatigue, Fatigue score, Japanese traditional herbal medicine, Oxidative stress |
| first_indexed | 2024-03-12T19:44:34Z |
| format | Article |
| id | doaj.art-b1018bcf9a8e4f52aff94f3c6cb4afef |
| institution | Directory Open Access Journal |
| issn | 2287-8882 |
| language | English |
| last_indexed | 2024-03-12T19:44:34Z |
| publishDate | 2018-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Prostate International |
| spelling | doaj.art-b1018bcf9a8e4f52aff94f3c6cb4afef2023-08-02T03:37:13ZengElsevierProstate International2287-88822018-06-01625560Kamikihito improves cancer-related fatigue by restoring balance between the sympathetic and parasympathetic nervous systemsSatoshi Tamada0Kyoko Ebisu1Sayaka Yasuda2Minoru Kato3Noriko Ninomiya4Takeshi Yamasaki5Taro Iguchi6Tatsuya Nakatani7Yasuyoshi Watanabe8Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan; Corresponding author. 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.RIKEN Center for Life Science Technologies, Kobe, Japan; Center for Health Science Innovation, Osaka City University, Osaka, JapanDepartment of Urology, Osaka City University Graduate School of Medicine, Osaka, JapanDepartment of Urology, Osaka City University Graduate School of Medicine, Osaka, JapanDepartment of Urology, Osaka City University Graduate School of Medicine, Osaka, JapanDepartment of Urology, Osaka City University Graduate School of Medicine, Osaka, JapanDepartment of Urology, Osaka City University Graduate School of Medicine, Osaka, JapanDepartment of Urology, Osaka City University Graduate School of Medicine, Osaka, JapanRIKEN Center for Life Science Technologies, Kobe, Japan; Center for Health Science Innovation, Osaka City University, Osaka, JapanBackground: Cancer-related fatigue is one of the most prevalent symptoms that patients with cancer experience, but the mechanisms underlying it are unknown. We aimed to quantify and mechanistically evaluate the improvement in fatigue related to administration of the Kampo medicine, Kamikihito. Materials and methods: Initially, we recruited outpatients with urological diseases and compared fatigue levels of 37 patients with cancer with a control group of 23 volunteers who had recovered completely from cancer or who were being treated for dysuria. Fatigue level was estimated using an autonomic function analyzer. Then, Kamikihito was administered to another 35 patients treated with hormone or antitumor therapy for prostate cancer and metastatic renal cell cancer. Subjective fatigue and other problems of the patients were assessed using the Chalder fatigue scale, the Center for Epidemiologic Studies Depression scale, and the Epworth sleepiness scale. Serum levels of derivatives of reactive oxygen species and biological antioxidant potential were also measured. Results: Patients in the cancer treatment group experienced more fatigue compared with the control patients when evaluated using an autonomic function analyzer. The group of 35 patients who were administered Kamikihito showed improved scores for fatigue, depression, and sleepiness. Autonomic nervous system balance was also improved with Kamikihito administration. The Kamikihito group also had significantly lower reactive oxygen species metabolite levels and significantly higher antioxidant potential. Conclusions: Fatigue was more serious in patients with cancer than in control patients. Kamikihito rescued this fatigue and improved anxiety and sleepiness. It restored autonomic nervous system balance and antioxidant function. Keywords: Autonomic nerve system, Cancer-related fatigue, Fatigue score, Japanese traditional herbal medicine, Oxidative stresshttp://www.sciencedirect.com/science/article/pii/S2287888217301484 |
| spellingShingle | Satoshi Tamada Kyoko Ebisu Sayaka Yasuda Minoru Kato Noriko Ninomiya Takeshi Yamasaki Taro Iguchi Tatsuya Nakatani Yasuyoshi Watanabe Kamikihito improves cancer-related fatigue by restoring balance between the sympathetic and parasympathetic nervous systems Prostate International |
| title | Kamikihito improves cancer-related fatigue by restoring balance between the sympathetic and parasympathetic nervous systems |
| title_full | Kamikihito improves cancer-related fatigue by restoring balance between the sympathetic and parasympathetic nervous systems |
| title_fullStr | Kamikihito improves cancer-related fatigue by restoring balance between the sympathetic and parasympathetic nervous systems |
| title_full_unstemmed | Kamikihito improves cancer-related fatigue by restoring balance between the sympathetic and parasympathetic nervous systems |
| title_short | Kamikihito improves cancer-related fatigue by restoring balance between the sympathetic and parasympathetic nervous systems |
| title_sort | kamikihito improves cancer related fatigue by restoring balance between the sympathetic and parasympathetic nervous systems |
| url | http://www.sciencedirect.com/science/article/pii/S2287888217301484 |
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