Role of prophylactic intravitreal antibiotics in open globe injuries.
<b>Purpose:</b> To determine the efficacy of prophylactic intravitreal antibiotics in reducing the incidence of endophthalmitis after trauma. <b> Methods:</b> This was a prospective, randomised, case control study of 70 consecutive patients with open globe injury. The pati...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2003-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2003;volume=51;issue=1;spage=39;epage=44;aulast=Narang |
| Summary: | <b>Purpose:</b> To determine the efficacy of prophylactic intravitreal antibiotics in reducing the incidence of endophthalmitis after trauma. <b> Methods:</b> This was a prospective, randomised, case control study of 70 consecutive patients with open globe injury. The patients were prospectively randomised into group I (32 eyes) and group II (38 eyes). Group I patients were given prophylactic intravitreal injection of vancomycin 1 mg and ceftazidime 2.25 mg at the conclusion of primary repair. Group II patients were not given prophylactic intravitreal antibiotics. All the patients received intravenous ciprofloxacin. <b> Results: </b> The incidence of endophthalmitis was higher in group II (7 of 38 eyes; 18.42%) compared to group I (2 of 32 eyes; 6.25%). Both the patients who developed endophthalmitis despite prophylactic intravitreal antibiotics in group I had an initially undetected intraocular foreign body (eyelash) in the vitreous cavity. <b> Conclusions:</b> Prophylactic intravitreal broad spectrum antibiotic injection decreases the risk of post-traumatic endophthalmitis. |
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| ISSN: | 0301-4738 |