Small but mighty: old and new parvoviruses of veterinary significance
Abstract In line with the Latin expression “sed parva forti” meaning “small but mighty,” the family Parvoviridae contains many of the smallest known viruses, some of which result in fatal or debilitating infections. In recent years, advances in metagenomic viral discovery techniques have dramaticall...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-10-01
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| Series: | Virology Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12985-021-01677-y |
| _version_ | 1819116498206064640 |
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| author | Mason C. Jager Joy E. Tomlinson Robert A. Lopez-Astacio Colin R. Parrish Gerlinde R. Van de Walle |
| author_facet | Mason C. Jager Joy E. Tomlinson Robert A. Lopez-Astacio Colin R. Parrish Gerlinde R. Van de Walle |
| author_sort | Mason C. Jager |
| collection | DOAJ |
| description | Abstract In line with the Latin expression “sed parva forti” meaning “small but mighty,” the family Parvoviridae contains many of the smallest known viruses, some of which result in fatal or debilitating infections. In recent years, advances in metagenomic viral discovery techniques have dramatically increased the identification of novel parvoviruses in both diseased and healthy individuals. While some of these discoveries have solved etiologic mysteries of well-described diseases in animals, many of the newly discovered parvoviruses appear to cause mild or no disease, or disease associations remain to be established. With the increased use of animal parvoviruses as vectors for gene therapy and oncolytic treatments in humans, it becomes all the more important to understand the diversity, pathogenic potential, and evolution of this diverse family of viruses. In this review, we discuss parvoviruses infecting vertebrate animals, with a special focus on pathogens of veterinary significance and viruses discovered within the last four years. |
| first_indexed | 2024-12-22T05:18:02Z |
| format | Article |
| id | doaj.art-b1032bcb706b4e72848d492bb2faeffd |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-12-22T05:18:02Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-b1032bcb706b4e72848d492bb2faeffd2022-12-21T18:37:49ZengBMCVirology Journal1743-422X2021-10-0118112910.1186/s12985-021-01677-ySmall but mighty: old and new parvoviruses of veterinary significanceMason C. Jager0Joy E. Tomlinson1Robert A. Lopez-Astacio2Colin R. Parrish3Gerlinde R. Van de Walle4Baker Institute for Animal Health, College of Veterinary Medicine, Cornell UniversityBaker Institute for Animal Health, College of Veterinary Medicine, Cornell UniversityBaker Institute for Animal Health, College of Veterinary Medicine, Cornell UniversityBaker Institute for Animal Health, College of Veterinary Medicine, Cornell UniversityBaker Institute for Animal Health, College of Veterinary Medicine, Cornell UniversityAbstract In line with the Latin expression “sed parva forti” meaning “small but mighty,” the family Parvoviridae contains many of the smallest known viruses, some of which result in fatal or debilitating infections. In recent years, advances in metagenomic viral discovery techniques have dramatically increased the identification of novel parvoviruses in both diseased and healthy individuals. While some of these discoveries have solved etiologic mysteries of well-described diseases in animals, many of the newly discovered parvoviruses appear to cause mild or no disease, or disease associations remain to be established. With the increased use of animal parvoviruses as vectors for gene therapy and oncolytic treatments in humans, it becomes all the more important to understand the diversity, pathogenic potential, and evolution of this diverse family of viruses. In this review, we discuss parvoviruses infecting vertebrate animals, with a special focus on pathogens of veterinary significance and viruses discovered within the last four years.https://doi.org/10.1186/s12985-021-01677-yPathogenicityAnimal parvovirusesViral therapeuticsViral metagenomicsAmdoparvovirusCopiparvovirus |
| spellingShingle | Mason C. Jager Joy E. Tomlinson Robert A. Lopez-Astacio Colin R. Parrish Gerlinde R. Van de Walle Small but mighty: old and new parvoviruses of veterinary significance Virology Journal Pathogenicity Animal parvoviruses Viral therapeutics Viral metagenomics Amdoparvovirus Copiparvovirus |
| title | Small but mighty: old and new parvoviruses of veterinary significance |
| title_full | Small but mighty: old and new parvoviruses of veterinary significance |
| title_fullStr | Small but mighty: old and new parvoviruses of veterinary significance |
| title_full_unstemmed | Small but mighty: old and new parvoviruses of veterinary significance |
| title_short | Small but mighty: old and new parvoviruses of veterinary significance |
| title_sort | small but mighty old and new parvoviruses of veterinary significance |
| topic | Pathogenicity Animal parvoviruses Viral therapeutics Viral metagenomics Amdoparvovirus Copiparvovirus |
| url | https://doi.org/10.1186/s12985-021-01677-y |
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