PLASMAPHERESIS IN THE TREATMENT OF MYASTHENIA GRAVIS: OUTCOME AND COMPLICATIONS
Objective: To assess the outcome and complications of plasmapharesis in treatment of myasthenia gravis and factors linked to poor outcome at hematology unit of a tertiary care teaching hospital of Pakistan Study Design: Prospective comparative study. Place and Duration of Study: Pak Emirates M...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Army Medical College Rawalpindi
2021-04-01
|
| Series: | Pakistan Armed Forces Medical Journal |
| Subjects: | |
| Online Access: | https://pafmj.org/index.php/PAFMJ/article/view/4024 |
| _version_ | 1818841996515606528 |
|---|---|
| author | Maryam Abbas Helen Mary Robert Asad Mahmood Saleem Ahmed Khan Mohammad Abdul Naeem Muhammad Ahsan Ayaz |
| author_facet | Maryam Abbas Helen Mary Robert Asad Mahmood Saleem Ahmed Khan Mohammad Abdul Naeem Muhammad Ahsan Ayaz |
| author_sort | Maryam Abbas |
| collection | DOAJ |
| description | Objective: To assess the outcome and complications of plasmapharesis in treatment of myasthenia gravis and factors linked to poor outcome at hematology unit of a tertiary care teaching hospital of Pakistan
Study Design: Prospective comparative study.
Place and Duration of Study: Pak Emirates Military Hospital/Armed Forces Institute of Pathology, Rawalpindi, from Jan 2018 to Jul 2019.
Methodology: A prospective study was conducted on patients of myasthenia gravis presented at our neurology department. All the complications of the procedure were recorded. Outcomes included recovery, shifting to intensive care unit and death. Pearson chi-square was applied to relate the factors with presence of complications or poor outcome.
Results: Hypotension 3 (6%) was the commonest complication faced by the patients followed by chest discomfort 2 (4%) during or after the plasmapharesis. Out of 50 patients, 47 (94%) recovered, 8 (16%) had minor complications, 2 (4%) were shifted to the intensive care unit and 1 (2%) died. Long duration of time between onset of symptoms and first session of plasmapharesis had a significant relationship (p-value <0.05) with presence of complications or poor outcome among the patients of myasthenia gravis undergoing plasmapharesis.
Conclusion: Plasmapharesis emerged as effective treatment for this immune based neurological disorder with limited side effects. A neurologist should be aware of these common minor and rare major side effects and pay special attention to the patients with generalized myasthenia gravis and those with long duration of time between onset of symptoms and first session of plasmapharesis.
Keywords: ,. |
| first_indexed | 2024-12-19T04:34:57Z |
| format | Article |
| id | doaj.art-b10387d243634c198306d91e478aa9fb |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-12-19T04:34:57Z |
| publishDate | 2021-04-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-b10387d243634c198306d91e478aa9fb2022-12-21T20:35:46ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422021-04-0171239640010.51253/pafmj.v71i2.40244024PLASMAPHERESIS IN THE TREATMENT OF MYASTHENIA GRAVIS: OUTCOME AND COMPLICATIONSMaryam Abbas0Helen Mary Robert1Asad Mahmood2Saleem Ahmed Khan3Mohammad Abdul Naeem4Muhammad Ahsan Ayaz5Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi PakistanObjective: To assess the outcome and complications of plasmapharesis in treatment of myasthenia gravis and factors linked to poor outcome at hematology unit of a tertiary care teaching hospital of Pakistan Study Design: Prospective comparative study. Place and Duration of Study: Pak Emirates Military Hospital/Armed Forces Institute of Pathology, Rawalpindi, from Jan 2018 to Jul 2019. Methodology: A prospective study was conducted on patients of myasthenia gravis presented at our neurology department. All the complications of the procedure were recorded. Outcomes included recovery, shifting to intensive care unit and death. Pearson chi-square was applied to relate the factors with presence of complications or poor outcome. Results: Hypotension 3 (6%) was the commonest complication faced by the patients followed by chest discomfort 2 (4%) during or after the plasmapharesis. Out of 50 patients, 47 (94%) recovered, 8 (16%) had minor complications, 2 (4%) were shifted to the intensive care unit and 1 (2%) died. Long duration of time between onset of symptoms and first session of plasmapharesis had a significant relationship (p-value <0.05) with presence of complications or poor outcome among the patients of myasthenia gravis undergoing plasmapharesis. Conclusion: Plasmapharesis emerged as effective treatment for this immune based neurological disorder with limited side effects. A neurologist should be aware of these common minor and rare major side effects and pay special attention to the patients with generalized myasthenia gravis and those with long duration of time between onset of symptoms and first session of plasmapharesis. Keywords: ,.https://pafmj.org/index.php/PAFMJ/article/view/4024myasthenia gravisoutcomeplasmapharesis |
| spellingShingle | Maryam Abbas Helen Mary Robert Asad Mahmood Saleem Ahmed Khan Mohammad Abdul Naeem Muhammad Ahsan Ayaz PLASMAPHERESIS IN THE TREATMENT OF MYASTHENIA GRAVIS: OUTCOME AND COMPLICATIONS Pakistan Armed Forces Medical Journal myasthenia gravis outcome plasmapharesis |
| title | PLASMAPHERESIS IN THE TREATMENT OF MYASTHENIA GRAVIS: OUTCOME AND COMPLICATIONS |
| title_full | PLASMAPHERESIS IN THE TREATMENT OF MYASTHENIA GRAVIS: OUTCOME AND COMPLICATIONS |
| title_fullStr | PLASMAPHERESIS IN THE TREATMENT OF MYASTHENIA GRAVIS: OUTCOME AND COMPLICATIONS |
| title_full_unstemmed | PLASMAPHERESIS IN THE TREATMENT OF MYASTHENIA GRAVIS: OUTCOME AND COMPLICATIONS |
| title_short | PLASMAPHERESIS IN THE TREATMENT OF MYASTHENIA GRAVIS: OUTCOME AND COMPLICATIONS |
| title_sort | plasmapheresis in the treatment of myasthenia gravis outcome and complications |
| topic | myasthenia gravis outcome plasmapharesis |
| url | https://pafmj.org/index.php/PAFMJ/article/view/4024 |
| work_keys_str_mv | AT maryamabbas plasmapheresisinthetreatmentofmyastheniagravisoutcomeandcomplications AT helenmaryrobert plasmapheresisinthetreatmentofmyastheniagravisoutcomeandcomplications AT asadmahmood plasmapheresisinthetreatmentofmyastheniagravisoutcomeandcomplications AT saleemahmedkhan plasmapheresisinthetreatmentofmyastheniagravisoutcomeandcomplications AT mohammadabdulnaeem plasmapheresisinthetreatmentofmyastheniagravisoutcomeandcomplications AT muhammadahsanayaz plasmapheresisinthetreatmentofmyastheniagravisoutcomeandcomplications |