Antiarrhythmic effects and mechanisms of sodium-glucose cotransporter 2 inhibitors: A mini review
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a new type of oral hypoglycaemic agent with good cardiovascular protective effects. There are several lines of clinical evidence suggest that SGLT2i can significantly reduce the risks of heart failure, cardiovascular death, and delay the progres...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.915455/full |
| _version_ | 1811345137887870976 |
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| author | Jinchun Wu Yanmin Liu Xiaojuan Wei Xiaofei Zhang Yi Ye Wei Li Xiaoling Su |
| author_facet | Jinchun Wu Yanmin Liu Xiaojuan Wei Xiaofei Zhang Yi Ye Wei Li Xiaoling Su |
| author_sort | Jinchun Wu |
| collection | DOAJ |
| description | Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a new type of oral hypoglycaemic agent with good cardiovascular protective effects. There are several lines of clinical evidence suggest that SGLT2i can significantly reduce the risks of heart failure, cardiovascular death, and delay the progression of chronic kidney disease. In addition, recent basic and clinical studies have also reported that SGLT2i also has good anti-arrhythmic effects. However, the exact mechanism is poorly understood. The aim of this review is to summarize recent clinical findings, studies of laboratory animals, and related study about this aspect of the antiarrhythmic effects of SGLT2i, to further explore its underlying mechanisms, safety, and prospects for clinical applications of it. |
| first_indexed | 2024-04-13T19:58:35Z |
| format | Article |
| id | doaj.art-b1048f117f444c389e1a275775715726 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-13T19:58:35Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-b1048f117f444c389e1a2757757157262022-12-22T02:32:16ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-08-01910.3389/fcvm.2022.915455915455Antiarrhythmic effects and mechanisms of sodium-glucose cotransporter 2 inhibitors: A mini reviewJinchun Wu0Yanmin Liu1Xiaojuan Wei2Xiaofei Zhang3Yi Ye4Wei Li5Xiaoling Su6Department of Cardiology, Qinghai Provincial People's Hospital, Xining, ChinaDepartment of Cardiology, Qinghai Provincial People's Hospital, Xining, ChinaDepartment of Cardiology, Qinghai Provincial People's Hospital, Xining, ChinaDepartment of Cardiology, Qinghai Provincial People's Hospital, Xining, ChinaGraduate School of Qinghai University, Qinghai University, Xining, ChinaDepartment of Cardiology, Qinghai Provincial People's Hospital, Xining, ChinaDepartment of Cardiology, Qinghai Provincial People's Hospital, Xining, ChinaSodium-glucose cotransporter 2 inhibitors (SGLT2i) are a new type of oral hypoglycaemic agent with good cardiovascular protective effects. There are several lines of clinical evidence suggest that SGLT2i can significantly reduce the risks of heart failure, cardiovascular death, and delay the progression of chronic kidney disease. In addition, recent basic and clinical studies have also reported that SGLT2i also has good anti-arrhythmic effects. However, the exact mechanism is poorly understood. The aim of this review is to summarize recent clinical findings, studies of laboratory animals, and related study about this aspect of the antiarrhythmic effects of SGLT2i, to further explore its underlying mechanisms, safety, and prospects for clinical applications of it.https://www.frontiersin.org/articles/10.3389/fcvm.2022.915455/fullNa+ homeostasisCa2+ homeostasisNa+-H+ exchanger regulatory factor (NHERF)1/2Na+-Ca2+ exchanger (NCX)ventricular arrhythmia (VAs)atrial fibrillation |
| spellingShingle | Jinchun Wu Yanmin Liu Xiaojuan Wei Xiaofei Zhang Yi Ye Wei Li Xiaoling Su Antiarrhythmic effects and mechanisms of sodium-glucose cotransporter 2 inhibitors: A mini review Frontiers in Cardiovascular Medicine Na+ homeostasis Ca2+ homeostasis Na+-H+ exchanger regulatory factor (NHERF)1/2 Na+-Ca2+ exchanger (NCX) ventricular arrhythmia (VAs) atrial fibrillation |
| title | Antiarrhythmic effects and mechanisms of sodium-glucose cotransporter 2 inhibitors: A mini review |
| title_full | Antiarrhythmic effects and mechanisms of sodium-glucose cotransporter 2 inhibitors: A mini review |
| title_fullStr | Antiarrhythmic effects and mechanisms of sodium-glucose cotransporter 2 inhibitors: A mini review |
| title_full_unstemmed | Antiarrhythmic effects and mechanisms of sodium-glucose cotransporter 2 inhibitors: A mini review |
| title_short | Antiarrhythmic effects and mechanisms of sodium-glucose cotransporter 2 inhibitors: A mini review |
| title_sort | antiarrhythmic effects and mechanisms of sodium glucose cotransporter 2 inhibitors a mini review |
| topic | Na+ homeostasis Ca2+ homeostasis Na+-H+ exchanger regulatory factor (NHERF)1/2 Na+-Ca2+ exchanger (NCX) ventricular arrhythmia (VAs) atrial fibrillation |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.915455/full |
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