Genetics of scleroderma: implications for personalized medicine?
<p>Abstract</p> <p>Significant advances have been made in understanding the genetic basis of systemic sclerosis (scleroderma) in recent years. Can these discoveries lead to individualized monitoring and treatment? Besides robustly replicated genetic susceptibility loci, several gen...
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| Format: | Article |
| Language: | English |
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BMC
2013-01-01
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| Series: | BMC Medicine |
| Subjects: | |
| Online Access: | http://www.biomedcentral.com/1741-7015/11/9 |
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| author | Assassi Shervin Radstake Timothy RDJ Mayes Maureen D Martin Javier |
| author_facet | Assassi Shervin Radstake Timothy RDJ Mayes Maureen D Martin Javier |
| author_sort | Assassi Shervin |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Significant advances have been made in understanding the genetic basis of systemic sclerosis (scleroderma) in recent years. Can these discoveries lead to individualized monitoring and treatment? Besides robustly replicated genetic susceptibility loci, several genes have been recently linked to various systemic sclerosis disease manifestations. Furthermore, inclusion of genetic studies in design and analysis of drug trials could lead to development of genetic biomarkers that predict treatment response. Future genetic studies in well-characterized systemic sclerosis cohorts paired with advanced analytic approaches can lead to development of genetic biomarkers for targeted diagnostic and therapeutic interventions in systemic sclerosis.</p> |
| first_indexed | 2024-12-20T11:53:10Z |
| format | Article |
| id | doaj.art-b107edf154e3400c9835f8cafc75454f |
| institution | Directory Open Access Journal |
| issn | 1741-7015 |
| language | English |
| last_indexed | 2024-12-20T11:53:10Z |
| publishDate | 2013-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj.art-b107edf154e3400c9835f8cafc75454f2022-12-21T19:41:43ZengBMCBMC Medicine1741-70152013-01-01111910.1186/1741-7015-11-9Genetics of scleroderma: implications for personalized medicine?Assassi ShervinRadstake Timothy RDJMayes Maureen DMartin Javier<p>Abstract</p> <p>Significant advances have been made in understanding the genetic basis of systemic sclerosis (scleroderma) in recent years. Can these discoveries lead to individualized monitoring and treatment? Besides robustly replicated genetic susceptibility loci, several genes have been recently linked to various systemic sclerosis disease manifestations. Furthermore, inclusion of genetic studies in design and analysis of drug trials could lead to development of genetic biomarkers that predict treatment response. Future genetic studies in well-characterized systemic sclerosis cohorts paired with advanced analytic approaches can lead to development of genetic biomarkers for targeted diagnostic and therapeutic interventions in systemic sclerosis.</p>http://www.biomedcentral.com/1741-7015/11/9systemic sclerosissclerodermageneticbiomarkerseverity |
| spellingShingle | Assassi Shervin Radstake Timothy RDJ Mayes Maureen D Martin Javier Genetics of scleroderma: implications for personalized medicine? BMC Medicine systemic sclerosis scleroderma genetic biomarker severity |
| title | Genetics of scleroderma: implications for personalized medicine? |
| title_full | Genetics of scleroderma: implications for personalized medicine? |
| title_fullStr | Genetics of scleroderma: implications for personalized medicine? |
| title_full_unstemmed | Genetics of scleroderma: implications for personalized medicine? |
| title_short | Genetics of scleroderma: implications for personalized medicine? |
| title_sort | genetics of scleroderma implications for personalized medicine |
| topic | systemic sclerosis scleroderma genetic biomarker severity |
| url | http://www.biomedcentral.com/1741-7015/11/9 |
| work_keys_str_mv | AT assassishervin geneticsofsclerodermaimplicationsforpersonalizedmedicine AT radstaketimothyrdj geneticsofsclerodermaimplicationsforpersonalizedmedicine AT mayesmaureend geneticsofsclerodermaimplicationsforpersonalizedmedicine AT martinjavier geneticsofsclerodermaimplicationsforpersonalizedmedicine |