Pediatric Swine Model of Methicillin-Resistant Staphylococcus aureus Sepsis-Induced Coagulopathy, Disseminated Microvascular Thrombosis, and Organ Injuries

Pediatric Swine Model of Methicillin-Resistant Staphylococcus aureus Sepsis-Induced Coagulopathy, Disseminated Microvascular Thrombosis, and Organ Injuries

CONTEXT:. Sepsis-induced coagulopathy leading to disseminated microvascular thrombosis is associated with high mortality and has no existing therapy. Despite the high prevalence of Gram-positive bacterial sepsis, especially methicillin-resistant Staphylococcus aureus (MRSA), there is a paucity of pu...

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Main Authors: Trung C. Nguyen, MD, Juan C. Marini, DVM, PhD, Bobby Guillory, PhD, Christian Valladolid-Brown, PhD, Marina Martinez-Vargas, PhD, Deepika Subramanyam, PhD, Daniel Cohen, MD, PhD, Sonya C. Cirlos, BS, Fong Lam, MD, Barbara Stoll, PhD, Inka C. Didelija, Caitlin Vonderohe, DVM, Renan Orellana, MD, Arun Saini, MD, Subhashree Pradhan, PhD, Dalia Bashir, MD, Moreshwar S. Desai, MD, Saul Flores, MD, Manpreet Virk, MD, Hossein Tcharmtchi, MD, Amir Navaei, MD, Sheldon Kaplan, MD, Linda Lamberth, BS, Kristina G. Hulten, PhD, Brooks P. Scull, MS, Carl E. Allen, MD, PhD, Ayse Akcan-Arikan, MD, K. Vinod Vijayan, PhD, Miguel A. Cruz, PhD
Format: Article
Language:English
Published: Wolters Kluwer 2023-06-01
Series:Critical Care Explorations
Online Access:http://journals.lww.com/10.1097/CCE.0000000000000916

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