Baseline HBV Loads Do Not Affect the Prognosis of Patients with Hepatocellular Carcinoma Receiving Anti-Programmed Cell Death-1 Immunotherapy
Xuqi Sun,1– 3,* Dandan Hu,1,2,* Zhoutian Yang,1,2 Zheng Liu,3,4 Juncheng Wang,1,2 Jinbin Chen,1,2 Li Xu,1,2 Zhongguo Zhou,1,2 Minshan Chen,1,2 Yaojun Zhang1,2 1Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2020-12-01
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| Series: | Journal of Hepatocellular Carcinoma |
| Subjects: | |
| Online Access: | https://www.dovepress.com/baseline-hbv-loads-do-not-affect-the-prognosis-of-patients-with-hepato-peer-reviewed-article-JHC |
| _version_ | 1819298438126239744 |
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| author | Sun X Hu D Yang Z Liu Z Wang J Chen J Xu L Zhou Z Chen M Zhang Y |
| author_facet | Sun X Hu D Yang Z Liu Z Wang J Chen J Xu L Zhou Z Chen M Zhang Y |
| author_sort | Sun X |
| collection | DOAJ |
| description | Xuqi Sun,1– 3,* Dandan Hu,1,2,* Zhoutian Yang,1,2 Zheng Liu,3,4 Juncheng Wang,1,2 Jinbin Chen,1,2 Li Xu,1,2 Zhongguo Zhou,1,2 Minshan Chen,1,2 Yaojun Zhang1,2 1Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, People’s Republic of China; 2Department of Liver Surgery, Sun Yat-Sen University Cancer Center, Guangzhou 510060, People’s Republic of China; 3Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510060, People’s Republic of China; 4Department of Nuclear Medicine, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, People’s Republic of China*These authors contributed equally to this workCorrespondence: Minshan Chen; Yaojun ZhangDepartment of Liver Surgery, Sun Yat-Sen University Cancer Center, Dongfeng East Road 651, Guangzhou, Guangdong 510000, People’s Republic of ChinaTel +86-20-87343828Fax +86-20-87343585Email chenmsh@sysucc.org.cn; zhangyuj@sysucc.org.cnBackground: A high hepatitis B virus (HBV) load is a common exclusion criterion in hepatocellular carcinoma (HCC) clinical trials for anti-programmed cell death (PD)-1 immunotherapy. However, the validity of this criterion is barely verified. This study aimed to evaluate the impact of baseline HBV DNA levels and antiviral therapy on the oncological outcomes and liver functions of patients with HCC receiving anti-PD-1 immunotherapy.Methods: We reviewed HCC trials related to anti-PD-(L)1 immunotherapy and whether they ruled out patients with increased HBV loads on clinicaltrials.gov. Then, for this retrospective study, we enrolled 253 HCC patients treated with anti-PD-1 blockade in our institution. Baseline information was compared between patients with low and high HBV loads. Overall survival (OS) and progression-free survival (PFS) were compared, and univariate and multivariate analyses were applied to identify potential risk factors for oncological outcomes and hepatic impairment.Results: Among 76 HCC clinical trials including 13,927 patients receiving anti-PD-(L)1 blockade, 41 (53.9%) excluded patients with relatively high baseline HBV loads. The PFS and OS did not differ significantly between patients with baseline HBV loads ≤ 2000 IU/mL and those with viral loads > 2000 IU/mL (p=0.615 and 0.982). The incidence of hepatic impairment showed no association with the baseline HBV load (p=0.319). Patients receiving antiviral therapy had a better OS than those without antiviral therapy in the high baseline HBV load group (p= 0.001).Conclusion: High HBV loads did not compromise the clinical outcomes of HCC patients receiving anti-PD-1 blockade. Antiviral therapy could improve the OS of HCC patients with high HBV loads.Keywords: hepatocellular carcinoma, immunotherapy, hepatitis B virus, viral load |
| first_indexed | 2024-12-24T05:29:54Z |
| format | Article |
| id | doaj.art-b1090ae7fa8544c388a3bd412e96fa20 |
| institution | Directory Open Access Journal |
| issn | 2253-5969 |
| language | English |
| last_indexed | 2024-12-24T05:29:54Z |
| publishDate | 2020-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Hepatocellular Carcinoma |
| spelling | doaj.art-b1090ae7fa8544c388a3bd412e96fa202022-12-21T17:13:13ZengDove Medical PressJournal of Hepatocellular Carcinoma2253-59692020-12-01Volume 733734559845Baseline HBV Loads Do Not Affect the Prognosis of Patients with Hepatocellular Carcinoma Receiving Anti-Programmed Cell Death-1 ImmunotherapySun XHu DYang ZLiu ZWang JChen JXu LZhou ZChen MZhang YXuqi Sun,1– 3,* Dandan Hu,1,2,* Zhoutian Yang,1,2 Zheng Liu,3,4 Juncheng Wang,1,2 Jinbin Chen,1,2 Li Xu,1,2 Zhongguo Zhou,1,2 Minshan Chen,1,2 Yaojun Zhang1,2 1Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, People’s Republic of China; 2Department of Liver Surgery, Sun Yat-Sen University Cancer Center, Guangzhou 510060, People’s Republic of China; 3Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510060, People’s Republic of China; 4Department of Nuclear Medicine, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, People’s Republic of China*These authors contributed equally to this workCorrespondence: Minshan Chen; Yaojun ZhangDepartment of Liver Surgery, Sun Yat-Sen University Cancer Center, Dongfeng East Road 651, Guangzhou, Guangdong 510000, People’s Republic of ChinaTel +86-20-87343828Fax +86-20-87343585Email chenmsh@sysucc.org.cn; zhangyuj@sysucc.org.cnBackground: A high hepatitis B virus (HBV) load is a common exclusion criterion in hepatocellular carcinoma (HCC) clinical trials for anti-programmed cell death (PD)-1 immunotherapy. However, the validity of this criterion is barely verified. This study aimed to evaluate the impact of baseline HBV DNA levels and antiviral therapy on the oncological outcomes and liver functions of patients with HCC receiving anti-PD-1 immunotherapy.Methods: We reviewed HCC trials related to anti-PD-(L)1 immunotherapy and whether they ruled out patients with increased HBV loads on clinicaltrials.gov. Then, for this retrospective study, we enrolled 253 HCC patients treated with anti-PD-1 blockade in our institution. Baseline information was compared between patients with low and high HBV loads. Overall survival (OS) and progression-free survival (PFS) were compared, and univariate and multivariate analyses were applied to identify potential risk factors for oncological outcomes and hepatic impairment.Results: Among 76 HCC clinical trials including 13,927 patients receiving anti-PD-(L)1 blockade, 41 (53.9%) excluded patients with relatively high baseline HBV loads. The PFS and OS did not differ significantly between patients with baseline HBV loads ≤ 2000 IU/mL and those with viral loads > 2000 IU/mL (p=0.615 and 0.982). The incidence of hepatic impairment showed no association with the baseline HBV load (p=0.319). Patients receiving antiviral therapy had a better OS than those without antiviral therapy in the high baseline HBV load group (p= 0.001).Conclusion: High HBV loads did not compromise the clinical outcomes of HCC patients receiving anti-PD-1 blockade. Antiviral therapy could improve the OS of HCC patients with high HBV loads.Keywords: hepatocellular carcinoma, immunotherapy, hepatitis B virus, viral loadhttps://www.dovepress.com/baseline-hbv-loads-do-not-affect-the-prognosis-of-patients-with-hepato-peer-reviewed-article-JHChepatocellular carcinomaimmunotherapyhepatitis b virusviral load |
| spellingShingle | Sun X Hu D Yang Z Liu Z Wang J Chen J Xu L Zhou Z Chen M Zhang Y Baseline HBV Loads Do Not Affect the Prognosis of Patients with Hepatocellular Carcinoma Receiving Anti-Programmed Cell Death-1 Immunotherapy Journal of Hepatocellular Carcinoma hepatocellular carcinoma immunotherapy hepatitis b virus viral load |
| title | Baseline HBV Loads Do Not Affect the Prognosis of Patients with Hepatocellular Carcinoma Receiving Anti-Programmed Cell Death-1 Immunotherapy |
| title_full | Baseline HBV Loads Do Not Affect the Prognosis of Patients with Hepatocellular Carcinoma Receiving Anti-Programmed Cell Death-1 Immunotherapy |
| title_fullStr | Baseline HBV Loads Do Not Affect the Prognosis of Patients with Hepatocellular Carcinoma Receiving Anti-Programmed Cell Death-1 Immunotherapy |
| title_full_unstemmed | Baseline HBV Loads Do Not Affect the Prognosis of Patients with Hepatocellular Carcinoma Receiving Anti-Programmed Cell Death-1 Immunotherapy |
| title_short | Baseline HBV Loads Do Not Affect the Prognosis of Patients with Hepatocellular Carcinoma Receiving Anti-Programmed Cell Death-1 Immunotherapy |
| title_sort | baseline hbv loads do not affect the prognosis of patients with hepatocellular carcinoma receiving anti programmed cell death 1 immunotherapy |
| topic | hepatocellular carcinoma immunotherapy hepatitis b virus viral load |
| url | https://www.dovepress.com/baseline-hbv-loads-do-not-affect-the-prognosis-of-patients-with-hepato-peer-reviewed-article-JHC |
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