Association between platelet-lymphocyte ratio and 90-day mortality in patients with intracerebral hemorrhage: data from the MIMIC-III database
BackgroundRecent evidence suggested that platelet-lymphocyte ratio (PLR) may play a role in the pathophysiology of intracerebral hemorrhage (ICH), but the results are controversial. This study aimed to explore the relationship between PLR and mortality in patients with ICH.MethodsAll data were extra...
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1234252/full |
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| author | Min Yuan Min Yuan Zhilong Xiao Huangyan Zhou Anxia Fu Zhimin Pei |
| author_facet | Min Yuan Min Yuan Zhilong Xiao Huangyan Zhou Anxia Fu Zhimin Pei |
| author_sort | Min Yuan |
| collection | DOAJ |
| description | BackgroundRecent evidence suggested that platelet-lymphocyte ratio (PLR) may play a role in the pathophysiology of intracerebral hemorrhage (ICH), but the results are controversial. This study aimed to explore the relationship between PLR and mortality in patients with ICH.MethodsAll data were extracted from the Medical Information Mart for Intensive Care (MIMIC) III database. The study outcome was 90-day mortality. Multivariable Cox regression analyses were used to calculate the adjusted hazard ratio (HR) with a 95% confidence interval (CI), and curve-fitting (restricted cubic spline) was used to assess the non-linear relationship.ResultsOf 1,442 patients, 1,043 patients with ICH were included. The overall 90-day mortality was 29.8% (311/1,043). When PLR was assessed in quartiles, the risk of 90-day mortality for ICH was lowest for quartile 2 (120.9 to <189.8: adjusted HR, 0.67; 95% CI: 0.48–0.93; P = 0.016), compared with those in quartile 1 (<120.9). Consistently in the threshold analysis, for every 1 unit increase in PLR, there was a 0.6% decrease in the risk of 90-day mortality for ICH (adjusted HR, 0.994; 95% CI: 0.988–0.999) in those with PLR <145.54, and a 0.2% increase in 90-day mortality (adjusted HR, 1.002; 95% CI: 1.000–1.003) in participants with PLR ≥145.54.ConclusionThere was a non-linear relationship between PLR and 90-day mortality for patients with ICH, with an inflection point at 145.54 and a minimal risk at 120.9 to <189.8 of PLR. |
| first_indexed | 2024-03-11T19:12:22Z |
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| language | English |
| last_indexed | 2024-03-11T19:12:22Z |
| publishDate | 2023-10-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-b109b4d358284a04b266dc6e8e4e5e7f2023-10-09T11:02:23ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-10-011410.3389/fneur.2023.12342521234252Association between platelet-lymphocyte ratio and 90-day mortality in patients with intracerebral hemorrhage: data from the MIMIC-III databaseMin Yuan0Min Yuan1Zhilong Xiao2Huangyan Zhou3Anxia Fu4Zhimin Pei5Graduate School, Nanchang University, Nanchang, ChinaDepartment of Neurology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaDepartment of Neurology, The Third Hospital of Nanchang, Nanchang, ChinaDepartment of Blood Transfusion, Jiangxi Cancer Hospital, The Second Affiliated Hospital of Nanchang Medical College, Jiangxi Clinical Research Center for Cancer, Nanchang, ChinaDepartment of Neurology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaThe Second People's Hospital of Nanchang County, Nanchang, ChinaBackgroundRecent evidence suggested that platelet-lymphocyte ratio (PLR) may play a role in the pathophysiology of intracerebral hemorrhage (ICH), but the results are controversial. This study aimed to explore the relationship between PLR and mortality in patients with ICH.MethodsAll data were extracted from the Medical Information Mart for Intensive Care (MIMIC) III database. The study outcome was 90-day mortality. Multivariable Cox regression analyses were used to calculate the adjusted hazard ratio (HR) with a 95% confidence interval (CI), and curve-fitting (restricted cubic spline) was used to assess the non-linear relationship.ResultsOf 1,442 patients, 1,043 patients with ICH were included. The overall 90-day mortality was 29.8% (311/1,043). When PLR was assessed in quartiles, the risk of 90-day mortality for ICH was lowest for quartile 2 (120.9 to <189.8: adjusted HR, 0.67; 95% CI: 0.48–0.93; P = 0.016), compared with those in quartile 1 (<120.9). Consistently in the threshold analysis, for every 1 unit increase in PLR, there was a 0.6% decrease in the risk of 90-day mortality for ICH (adjusted HR, 0.994; 95% CI: 0.988–0.999) in those with PLR <145.54, and a 0.2% increase in 90-day mortality (adjusted HR, 1.002; 95% CI: 1.000–1.003) in participants with PLR ≥145.54.ConclusionThere was a non-linear relationship between PLR and 90-day mortality for patients with ICH, with an inflection point at 145.54 and a minimal risk at 120.9 to <189.8 of PLR.https://www.frontiersin.org/articles/10.3389/fneur.2023.1234252/fullintracerebral hemorrhageplatelet-lymphocyte ratiomortalityretrospective cohort studyMIMIC database |
| spellingShingle | Min Yuan Min Yuan Zhilong Xiao Huangyan Zhou Anxia Fu Zhimin Pei Association between platelet-lymphocyte ratio and 90-day mortality in patients with intracerebral hemorrhage: data from the MIMIC-III database Frontiers in Neurology intracerebral hemorrhage platelet-lymphocyte ratio mortality retrospective cohort study MIMIC database |
| title | Association between platelet-lymphocyte ratio and 90-day mortality in patients with intracerebral hemorrhage: data from the MIMIC-III database |
| title_full | Association between platelet-lymphocyte ratio and 90-day mortality in patients with intracerebral hemorrhage: data from the MIMIC-III database |
| title_fullStr | Association between platelet-lymphocyte ratio and 90-day mortality in patients with intracerebral hemorrhage: data from the MIMIC-III database |
| title_full_unstemmed | Association between platelet-lymphocyte ratio and 90-day mortality in patients with intracerebral hemorrhage: data from the MIMIC-III database |
| title_short | Association between platelet-lymphocyte ratio and 90-day mortality in patients with intracerebral hemorrhage: data from the MIMIC-III database |
| title_sort | association between platelet lymphocyte ratio and 90 day mortality in patients with intracerebral hemorrhage data from the mimic iii database |
| topic | intracerebral hemorrhage platelet-lymphocyte ratio mortality retrospective cohort study MIMIC database |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1234252/full |
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