Thrombotic microangiopathy associated with use of interferon-beta
Teresa Olea,1 Raquel Díaz-Mancebo,1 Maria-Luz Picazo,2 Jorge Martínez-Ara,1 Angel Robles,3 Rafael Selgas,11Departments of Nephrology, 2Pathology, 3Internal Medicine, Hospital Universitario La Paz, Madrid, SpainAbstract: Interferon-beta is widely used for the treatment o...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2012-06-01
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| Series: | International Journal of Nephrology and Renovascular Disease |
| Online Access: | http://www.dovepress.com/thrombotic-microangiopathy-associated-with-use-of-interferon-beta-a10128 |
| _version_ | 1811262068035158016 |
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| author | Robles A Martinez-Ara J Picazo ML Diaz-Mancebo R Olea T Selgas R |
| author_facet | Robles A Martinez-Ara J Picazo ML Diaz-Mancebo R Olea T Selgas R |
| author_sort | Robles A |
| collection | DOAJ |
| description | Teresa Olea,1 Raquel Díaz-Mancebo,1 Maria-Luz Picazo,2 Jorge Martínez-Ara,1 Angel Robles,3 Rafael Selgas,11Departments of Nephrology, 2Pathology, 3Internal Medicine, Hospital Universitario La Paz, Madrid, SpainAbstract: Interferon-beta is widely used for the treatment of relapsing multiple sclerosis. The drug is usually well tolerated, but autoimmune adverse effects, including kidney disease, have been reported. Only a few cases of hemolytic uremic syndrome-thrombotic microangiopathy associated interferon-alpha have been described so far, and even fewer with beta-interferon. We report a patient who developed thrombotic microangiopathy during treatment with interferon-beta and improved after discontinuation and steroid therapy. Complement cascade and antiphospholipid antibodies are investigated. The spectrum of renal diseases associated with interferon-beta treatment is also reviewed.Keywords: thrombotic microangiopathy hemolytic uremic syndrome, multiple sclerosis, interferon-beta |
| first_indexed | 2024-04-12T19:18:29Z |
| format | Article |
| id | doaj.art-b109bd18c1184b21a33728df9b3e2ec4 |
| institution | Directory Open Access Journal |
| issn | 1178-7058 |
| language | English |
| last_indexed | 2024-04-12T19:18:29Z |
| publishDate | 2012-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nephrology and Renovascular Disease |
| spelling | doaj.art-b109bd18c1184b21a33728df9b3e2ec42022-12-22T03:19:40ZengDove Medical PressInternational Journal of Nephrology and Renovascular Disease1178-70582012-06-012012default97100Thrombotic microangiopathy associated with use of interferon-betaRobles AMartinez-Ara JPicazo MLDiaz-Mancebo ROlea TSelgas RTeresa Olea,1 Raquel Díaz-Mancebo,1 Maria-Luz Picazo,2 Jorge Martínez-Ara,1 Angel Robles,3 Rafael Selgas,11Departments of Nephrology, 2Pathology, 3Internal Medicine, Hospital Universitario La Paz, Madrid, SpainAbstract: Interferon-beta is widely used for the treatment of relapsing multiple sclerosis. The drug is usually well tolerated, but autoimmune adverse effects, including kidney disease, have been reported. Only a few cases of hemolytic uremic syndrome-thrombotic microangiopathy associated interferon-alpha have been described so far, and even fewer with beta-interferon. We report a patient who developed thrombotic microangiopathy during treatment with interferon-beta and improved after discontinuation and steroid therapy. Complement cascade and antiphospholipid antibodies are investigated. The spectrum of renal diseases associated with interferon-beta treatment is also reviewed.Keywords: thrombotic microangiopathy hemolytic uremic syndrome, multiple sclerosis, interferon-betahttp://www.dovepress.com/thrombotic-microangiopathy-associated-with-use-of-interferon-beta-a10128 |
| spellingShingle | Robles A Martinez-Ara J Picazo ML Diaz-Mancebo R Olea T Selgas R Thrombotic microangiopathy associated with use of interferon-beta International Journal of Nephrology and Renovascular Disease |
| title | Thrombotic microangiopathy associated with use of interferon-beta |
| title_full | Thrombotic microangiopathy associated with use of interferon-beta |
| title_fullStr | Thrombotic microangiopathy associated with use of interferon-beta |
| title_full_unstemmed | Thrombotic microangiopathy associated with use of interferon-beta |
| title_short | Thrombotic microangiopathy associated with use of interferon-beta |
| title_sort | thrombotic microangiopathy associated with use of interferon beta |
| url | http://www.dovepress.com/thrombotic-microangiopathy-associated-with-use-of-interferon-beta-a10128 |
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