The Relationship between Hyperuricemia and Echocardiographic Parameters in Patients with Chronic Atrial Fibrillation
<i>Purpose</i> Uric acid serves as a marker for cardiovascular risk and is often linked to inflammation and oxidative stress. There is evidence suggesting an association between uric acid and atrial fibrillation (AF), including its severity and occurrence of crises, as well as its involv...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/15/5034 |
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| author | Mikel Jordhani Majlinda Cafka Joana Seiti Vivencio Barrios |
| author_facet | Mikel Jordhani Majlinda Cafka Joana Seiti Vivencio Barrios |
| author_sort | Mikel Jordhani |
| collection | DOAJ |
| description | <i>Purpose</i> Uric acid serves as a marker for cardiovascular risk and is often linked to inflammation and oxidative stress. There is evidence suggesting an association between uric acid and atrial fibrillation (AF), including its severity and occurrence of crises, as well as its involvement in cardiovascular mechanisms. The objective of this study was to assess the correlation between hyperuricemia and echocardiographic features in patients with chronic AF lasting for more than 5 years. <i>Methods</i> This case-control study involved 107 patients diagnosed with chronic non-valvular AF. Uric acid levels were measured in all patients, and they were divided into two groups: the first group consisted of 66 patients with hyperuricemia (>7.2 mg/dL), while the second group included 41 patients with normal uric acid levels. Echocardiography (TTE) was performed to evaluate each patient. Various clinical and echocardiographic parameters, such as left ventricle telediastolic (LVTDD) and telesystolic (LVTSD) diameters, left atrial diameter (LAD), aortic diameter (AoD), ejection fraction (EF), and pulmonary artery pressure (PAP), were analyzed. <i>Results</i> Binary logistic regression analysis revealed a statistically significant relationship between uric acid levels (>7.2 mg/dL) and LAD. For each unit increase in LAD, the probability of having hyperuricemia increased by 9% [odds ratio (OD): 0.91, 95% confidence interval (CI): 0.84—0.99]. A significant relationship was found between uric acid levels (>8 mg/dL) and LVESD (<i>p</i> = 0.045) as well as PAP (<i>p</i> = 0.006). For every unit increase in LVESD, the likelihood of having uric acid levels greater than 8 mg/dL increased by 22% [OD: 0.82, 95% CI: 0.67—0.99, b = −0.2]. Likewise, for each unit increase in PAP, the probability of having uric acid levels greater than 8 mg/dL was 9.4% [OD: 0.91, 95% CI: 0.86—0.97, b = −0.09]. <i>Conclusions</i> This study demonstrates that hyperuricemia has a significant relationship with the development of atrial remodeling, with an important association observed between hyperuricemia and an increase in left atrial diameter. Hyperuricemia is also correlated with an enlargement of the left ventricle end-systolic diameter and pulmonary artery pressure, showing a possible influence that hyperuricemia might have also left ventricle morphology and right ventricle function. |
| first_indexed | 2024-03-11T00:24:41Z |
| format | Article |
| id | doaj.art-b109d6d5d84d4712923bd69f98f735b9 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T00:24:41Z |
| publishDate | 2023-07-01 |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-b109d6d5d84d4712923bd69f98f735b92023-11-18T23:08:30ZengMDPI AGJournal of Clinical Medicine2077-03832023-07-011215503410.3390/jcm12155034The Relationship between Hyperuricemia and Echocardiographic Parameters in Patients with Chronic Atrial FibrillationMikel Jordhani0Majlinda Cafka1Joana Seiti2Vivencio Barrios3Internal Medicine Department, Korça Regional Hospital, 7001 Korça, AlbaniaCardiovascular Diseases Department, UHC “Mother Teresa”, 1000 Tirana, AlbaniaCardiovascular Diseases Department, UHC “Mother Teresa”, 1000 Tirana, AlbaniaAdult Cardiology Department, University Hospital Ramon y Cajal, 28034 Madrid, Spain<i>Purpose</i> Uric acid serves as a marker for cardiovascular risk and is often linked to inflammation and oxidative stress. There is evidence suggesting an association between uric acid and atrial fibrillation (AF), including its severity and occurrence of crises, as well as its involvement in cardiovascular mechanisms. The objective of this study was to assess the correlation between hyperuricemia and echocardiographic features in patients with chronic AF lasting for more than 5 years. <i>Methods</i> This case-control study involved 107 patients diagnosed with chronic non-valvular AF. Uric acid levels were measured in all patients, and they were divided into two groups: the first group consisted of 66 patients with hyperuricemia (>7.2 mg/dL), while the second group included 41 patients with normal uric acid levels. Echocardiography (TTE) was performed to evaluate each patient. Various clinical and echocardiographic parameters, such as left ventricle telediastolic (LVTDD) and telesystolic (LVTSD) diameters, left atrial diameter (LAD), aortic diameter (AoD), ejection fraction (EF), and pulmonary artery pressure (PAP), were analyzed. <i>Results</i> Binary logistic regression analysis revealed a statistically significant relationship between uric acid levels (>7.2 mg/dL) and LAD. For each unit increase in LAD, the probability of having hyperuricemia increased by 9% [odds ratio (OD): 0.91, 95% confidence interval (CI): 0.84—0.99]. A significant relationship was found between uric acid levels (>8 mg/dL) and LVESD (<i>p</i> = 0.045) as well as PAP (<i>p</i> = 0.006). For every unit increase in LVESD, the likelihood of having uric acid levels greater than 8 mg/dL increased by 22% [OD: 0.82, 95% CI: 0.67—0.99, b = −0.2]. Likewise, for each unit increase in PAP, the probability of having uric acid levels greater than 8 mg/dL was 9.4% [OD: 0.91, 95% CI: 0.86—0.97, b = −0.09]. <i>Conclusions</i> This study demonstrates that hyperuricemia has a significant relationship with the development of atrial remodeling, with an important association observed between hyperuricemia and an increase in left atrial diameter. Hyperuricemia is also correlated with an enlargement of the left ventricle end-systolic diameter and pulmonary artery pressure, showing a possible influence that hyperuricemia might have also left ventricle morphology and right ventricle function.https://www.mdpi.com/2077-0383/12/15/5034atrial fibrillationuric acidechocardiographyatrial dilation |
| spellingShingle | Mikel Jordhani Majlinda Cafka Joana Seiti Vivencio Barrios The Relationship between Hyperuricemia and Echocardiographic Parameters in Patients with Chronic Atrial Fibrillation Journal of Clinical Medicine atrial fibrillation uric acid echocardiography atrial dilation |
| title | The Relationship between Hyperuricemia and Echocardiographic Parameters in Patients with Chronic Atrial Fibrillation |
| title_full | The Relationship between Hyperuricemia and Echocardiographic Parameters in Patients with Chronic Atrial Fibrillation |
| title_fullStr | The Relationship between Hyperuricemia and Echocardiographic Parameters in Patients with Chronic Atrial Fibrillation |
| title_full_unstemmed | The Relationship between Hyperuricemia and Echocardiographic Parameters in Patients with Chronic Atrial Fibrillation |
| title_short | The Relationship between Hyperuricemia and Echocardiographic Parameters in Patients with Chronic Atrial Fibrillation |
| title_sort | relationship between hyperuricemia and echocardiographic parameters in patients with chronic atrial fibrillation |
| topic | atrial fibrillation uric acid echocardiography atrial dilation |
| url | https://www.mdpi.com/2077-0383/12/15/5034 |
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