Microextraction by packed sorbent of synthetic tryptamines from urine and ion mobility spectrometry determination
A procedure for the determination of N,N-dipropyltryptamine, 5‑methoxy-N,N-dimethyltryptamine, and 5‑methoxy-N-methyl-N-isopropyltryptamine in urine has been developed based on a microextraction by packed sorbent (MEPS) followed by ion mobility spectrometry determination. The combination of microext...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Advances in Sample Preparation |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772582023000050 |
| _version_ | 1811160827698348032 |
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| author | María Aparici-Lozano Sergio Armenta Salvador Garrigues Francesc A. Esteve-Turrillas |
| author_facet | María Aparici-Lozano Sergio Armenta Salvador Garrigues Francesc A. Esteve-Turrillas |
| author_sort | María Aparici-Lozano |
| collection | DOAJ |
| description | A procedure for the determination of N,N-dipropyltryptamine, 5‑methoxy-N,N-dimethyltryptamine, and 5‑methoxy-N-methyl-N-isopropyltryptamine in urine has been developed based on a microextraction by packed sorbent (MEPS) followed by ion mobility spectrometry determination. The combination of microextraction by packed sorbent with ion mobility spectrometry provided promising advantages for in-field screening of new psychoactive substances in urine, due to its simplicity, automation, and portability. The effect of sample pH and ionic strength, and the number of loading and elution steps has been evaluated. The obtained limits of quantification ranged from 21 to 29 µg L−1, and accuracy and precision were evaluated by the determination of blank urine samples spiked at limits of quantification, 250, and 500 µg L−1 synthetic tryptamines, with recovery values in the range of 76–95% and relative standard deviations lower than 20%. Moreover, the environmental impact and greenness of the proposed extraction method has been evaluated, providing an AGREEprep score of 0.62. Thus, the developed methodology can be considered a reliable and green screening methodology for in-field abuse drug consumption detection. |
| first_indexed | 2024-04-10T06:04:10Z |
| format | Article |
| id | doaj.art-b109f60207cf489686981fc66ff6a6d2 |
| institution | Directory Open Access Journal |
| issn | 2772-5820 |
| language | English |
| last_indexed | 2024-04-10T06:04:10Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Sample Preparation |
| spelling | doaj.art-b109f60207cf489686981fc66ff6a6d22023-03-03T04:25:46ZengElsevierAdvances in Sample Preparation2772-58202023-02-015100055Microextraction by packed sorbent of synthetic tryptamines from urine and ion mobility spectrometry determinationMaría Aparici-Lozano0Sergio Armenta1Salvador Garrigues2Francesc A. Esteve-Turrillas3Department of Analytical Chemistry, University of Valencia, Jerónimo Muñoz Building, 50th Dr. Moliner St., Burjassot 46100, SpainDepartment of Analytical Chemistry, University of Valencia, Jerónimo Muñoz Building, 50th Dr. Moliner St., Burjassot 46100, SpainDepartment of Analytical Chemistry, University of Valencia, Jerónimo Muñoz Building, 50th Dr. Moliner St., Burjassot 46100, SpainCorresponding author.; Department of Analytical Chemistry, University of Valencia, Jerónimo Muñoz Building, 50th Dr. Moliner St., Burjassot 46100, SpainA procedure for the determination of N,N-dipropyltryptamine, 5‑methoxy-N,N-dimethyltryptamine, and 5‑methoxy-N-methyl-N-isopropyltryptamine in urine has been developed based on a microextraction by packed sorbent (MEPS) followed by ion mobility spectrometry determination. The combination of microextraction by packed sorbent with ion mobility spectrometry provided promising advantages for in-field screening of new psychoactive substances in urine, due to its simplicity, automation, and portability. The effect of sample pH and ionic strength, and the number of loading and elution steps has been evaluated. The obtained limits of quantification ranged from 21 to 29 µg L−1, and accuracy and precision were evaluated by the determination of blank urine samples spiked at limits of quantification, 250, and 500 µg L−1 synthetic tryptamines, with recovery values in the range of 76–95% and relative standard deviations lower than 20%. Moreover, the environmental impact and greenness of the proposed extraction method has been evaluated, providing an AGREEprep score of 0.62. Thus, the developed methodology can be considered a reliable and green screening methodology for in-field abuse drug consumption detection.http://www.sciencedirect.com/science/article/pii/S2772582023000050New psychoactive substancesTryptaminesUrineMicroextraction by packed sorbentIon mobility spectrometryGreen analytical chemistry |
| spellingShingle | María Aparici-Lozano Sergio Armenta Salvador Garrigues Francesc A. Esteve-Turrillas Microextraction by packed sorbent of synthetic tryptamines from urine and ion mobility spectrometry determination Advances in Sample Preparation New psychoactive substances Tryptamines Urine Microextraction by packed sorbent Ion mobility spectrometry Green analytical chemistry |
| title | Microextraction by packed sorbent of synthetic tryptamines from urine and ion mobility spectrometry determination |
| title_full | Microextraction by packed sorbent of synthetic tryptamines from urine and ion mobility spectrometry determination |
| title_fullStr | Microextraction by packed sorbent of synthetic tryptamines from urine and ion mobility spectrometry determination |
| title_full_unstemmed | Microextraction by packed sorbent of synthetic tryptamines from urine and ion mobility spectrometry determination |
| title_short | Microextraction by packed sorbent of synthetic tryptamines from urine and ion mobility spectrometry determination |
| title_sort | microextraction by packed sorbent of synthetic tryptamines from urine and ion mobility spectrometry determination |
| topic | New psychoactive substances Tryptamines Urine Microextraction by packed sorbent Ion mobility spectrometry Green analytical chemistry |
| url | http://www.sciencedirect.com/science/article/pii/S2772582023000050 |
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