Depletion of the chromatin looping proteins CTCF and cohesin causes chromatin compaction: insight into chromatin folding by polymer modelling.

Depletion of the chromatin looping proteins CTCF and cohesin causes chromatin compaction: insight into chromatin folding by polymer modelling.

Folding of the chromosomal fibre in interphase nuclei is an important element in the regulation of gene expression. For instance, physical contacts between promoters and enhancers are a key element in cell-type-specific transcription. We know remarkably little about the principles that control chrom...

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Bibliographic Details
Main Authors: Mariliis Tark-Dame, Hansjoerg Jerabek, Erik M M Manders, Ingrid M van der Wateren, Dieter W Heermann, Roel van Driel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-10-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4191888?pdf=render

Internet

http://europepmc.org/articles/PMC4191888?pdf=render

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